[1]张宇睿,徐文清.电离辐射对线粒体损伤的研究进展[J].国际放射医学核医学杂志,2016,40(2):154-158.[doi:10.3760/cma.j.issn.1673-4114.2016.02.014]
 Zhang Yurui,Xu Wenqing.Damages of ionizing radiation on mitochondria[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):154-158.[doi:10.3760/cma.j.issn.1673-4114.2016.02.014]
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电离辐射对线粒体损伤的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第2期
页码:
154-158
栏目:
出版日期:
2016-03-25

文章信息/Info

Title:
Damages of ionizing radiation on mitochondria
作者:
张宇睿 徐文清
300192 天津, 中国医学科学院北京协和医学院放射医学研究所, 天津市放射医学与分子核医学重点实验室
Author(s):
Zhang Yurui Xu Wenqing
Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China
关键词:
辐射电离线粒体氧化性应激
Keywords:
RadiationionizingMitochondriaOxidative stress
DOI:
10.3760/cma.j.issn.1673-4114.2016.02.014
摘要:
细胞核中的DNA被认为是电离辐射的首要靶点,其损伤效应备受关注。近年来随着研究的不断深入,发现线粒体也是电离辐射的重要靶点。线粒体作为人体唯一含有编码DNA的细胞器,受到电离辐射后发生氧化应激不仅影响细胞的正常功能,甚至导致细胞凋亡。笔者通过现有的研究数据总结了受到电离辐射后线粒体功能和形态的变化,从而为辐射防护提供新的思路。
Abstract:
The radiobiology hypothesis is widely accepted by people that damage to the nuclear DNA is the main cause for the effects of radiation. However, some studies shown that the extranulear radiation effects are also very important, especially for mitochondria which contains the coding DNA and important proteins. Mitochondria plays a very important role in oxidative stress and cell death after irradiation. Some experiments present the effects of ionizing radiation on the mitochondria. Here, we discussed the ionizing radiation how to influence the mitochondria. And authors summary some available research data that specific protection of mitochondria could reduce damage to healthy cells exposed to ionizing radiation.

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备注/Memo

备注/Memo:
收稿日期:2016-01-06。
基金项目:国家自然科学基金(81273005);天津市应用基础与前沿技术研究重点项目(14JCZDJC36400);中国医学科学院放射医学研究所发展基金(SF1528)
通讯作者:徐文清,Email:xuwenqing@irm-cams.ac.cn
更新日期/Last Update: 1900-01-01