[1]徐金苹,袁德晓,张江虹,等.辐射诱导的外泌体在肿瘤细胞侵袭转移中的作用[J].国际放射医学核医学杂志,2015,39(2):144-148.[doi:10.3760/cma.j.issn.1673-4114.2015.02.009]
 Xu Jinping,Yuan Dexiao,Zhang Jianghong,et al.The role of radiation-induced exosomes in tumor invasion and metastasis[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):144-148.[doi:10.3760/cma.j.issn.1673-4114.2015.02.009]
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辐射诱导的外泌体在肿瘤细胞侵袭转移中的作用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第2期
页码:
144-148
栏目:
出版日期:
2015-03-25

文章信息/Info

Title:
The role of radiation-induced exosomes in tumor invasion and metastasis
作者:
徐金苹 袁德晓 张江虹 邵春林
复旦大学放射医学研究所, 上海, 200032
Author(s):
Xu Jinping Yuan Dexiao Zhang Jianghong Shao Chunlin
Institute of Radiation Medicine, Fudan Universtiy, Shanghai, 200032, China
关键词:
肿瘤辐射外泌体肿瘤侵润肿瘤转移
Keywords:
TumorIrradiationExosomesInvasivenessMetastasis
DOI:
10.3760/cma.j.issn.1673-4114.2015.02.009
摘要:
外泌体(Exosomes)是一种在细胞内形成并分泌到细胞外的具有膜结构的小囊泡体,直径约为40~100 nm,内含大量microRNAs(miRNAs)及蛋白质,可通过信息传递在细胞间通讯中发挥重要作用。肿瘤细胞通过外泌体可以促进癌基因、功能蛋白分子、肿瘤相关miRNAs的转移,引起肿瘤微环境的改变和重编程,对肿瘤的发生发展、侵袭及转移产生影响。笔者对肿瘤外泌体的结构特点、生物合成与分泌机制,特别是辐射诱导的外泌体在肿瘤细胞侵袭转移中的作用进行综述。
Abstract:
Exosomes are small membrane vesicles with a size of 40~100 nm in diameter released ubiquitously by cells.They contain a large amount of microRNAs and proteins and play a critical role in intercellular communication.Tumor cells can release more exosomes tllan normal cells.These exosomes influence tumor environment by transferring proteins, RNAs, and lipids between cells, thus aiding invasion and metastasis.This paper reviewed the structure characteristics, biogenesis, secretion pathway, and the function of radiation-induced exosomes and discussed its role in tumor invasion and metastasis.

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备注/Memo

备注/Memo:
收稿日期:2014-10-28。
基金项目:国家自然科学基金(项目编号:81273001,11179002,31200631);教育部高等学校博士学科点专项科研基金(项目编号:20120071110057)
通讯作者:邵春林,Email:clshao@shmu.edu.cn
更新日期/Last Update: 1900-01-01