[1]张倩如,李海涛,田红旗.小分子辐射防护药物的研究进展[J].国际放射医学核医学杂志,2016,40(5):394-402.[doi:10.3760/cma.j.issn.1673-4114.2016.05.012]
 Zhang Qianru,Li Haitao,Tian Hongqi.Small molecule compounds against radiation:research advances[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):394-402.[doi:10.3760/cma.j.issn.1673-4114.2016.05.012]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第5期
页码:
394-402
栏目:
综述
出版日期:
2016-09-25

文章信息/Info

Title:
Small molecule compounds against radiation:research advances
作者:
张倩如1 李海涛2 田红旗1
1. 300192 天津, 中国医学科学院北京协和医学院放射医学研究所, 天津市放射医学与分子核医学重点实验室;
2. 300192, 天津滨江药物研发有限公司
Author(s):
Zhang Qianru1 Li Haitao2 Tian Hongqi1
1. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China;
2. Tianjin Binjiang Pharma, Inc, Tianjin 300192, China
关键词:
辐射电离辐射损伤辐射防护剂抗氧化剂自由基清除剂
Keywords:
RadiationionizingRadiation injuriesRadiation-protective agentsAntioxidantsFree radical scavengers
DOI:
10.3760/cma.j.issn.1673-4114.2016.05.012
摘要:
辐射防护药物能减少辐射损伤,促进损伤恢复,与细胞因子等大分子药物相比,小分子辐射防护药使用方便,没有潜在的免疫原风险。笔者汇总了硫醇类化合物、天然抗氧化剂、氮氧自由基、血管紧张素转化酶抑制剂等几类不同的辐射防护药物,对其辐射防护效果以及作用机制进行了总结、归纳,并对此类药物的研发前景进行了展望,旨在为辐射防护药物的进一步研发提供思路。
Abstract:
Radioprotectors are designed to disrupt the progress of damage caused by radiation in normal tissues and to promote the recovery of the damaged tissues. This article review the function of the following agents as radioprotectors and their mechanism of action:sulfhydryl compounds, natural antioxidants, nitroxides, and angiotensin-converting enzyme inhibitors. Prospective functions of these agents were also discussed. This article hope to provide researchers with insights into radioprotector research.

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备注/Memo

备注/Memo:
收稿日期:2016-08-25
基金项目:中国医学科学院放射医学研究所发展基金(1531);中国医学科学院放射医学研究所科研创新团队项目(创新1649)
通讯作者:田红旗,Email:tianhongqi@irm-cams.ac.cn
更新日期/Last Update: 1900-01-01