[1]尹培,边艳珠.体内凋亡细胞显像的研究进展[J].国际放射医学核医学杂志,2009,33(5):279-282.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.007]
　YIN Pei,BIAN Yan-zhu.Development of apoptosis imaging in vivo[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):279-282.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.007]
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体内凋亡细胞显像的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第5期
页码:
279-282
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Development of apoptosis imaging in vivo
作者:
尹培;  边艳珠
河北省人民医院核医学科, 石家庄 050051
Author(s):
YIN Pei;  BIAN Yan-zhu
Department of Nuclear Medicine, Hebei General Hospital, Shijiazhuang 050051, China
关键词:
细胞凋亡; 放射性核素显像; 磁共振成像; 光学成像; 超声检查; Annexin V
Keywords:
Apoptosis; Radionuclide imaging; Magnetic resonance imaging; Optical imaging; Ultrasonography; Annexin V
DOI:
10.3760/cnla.j.issn.1673-4114.2009.05.007
摘要:
目前,疾病的诊断及治疗已进入分子水平阶段,细胞凋亡的检测技术也不断更新和发展。活体内细胞凋亡显像符合生理代谢的特点,能够对疾病实行早期、活体、无创及定量检查。其主要显像方法有:磁共振成像、光学成像、超声检查及放射性核素显像等。其中,以放射性核素凋亡显像的研究应用尤为突出,已应用于心血管疾病、中枢神经系统疾病、移植排斥反应以及肿瘤诊治等方面。
Abstract:
While the diagnosis and treatment of diseases has entered the molecular level,apoptosis detection techniques are also continuously updated and developed,including magnetic resonance imaging,optical imaging,ultrasound and radionuclide imaging.Apoptosis plays a key role in the pathogenesis of many disorders including cerebral and myocardial ischemia,autoimmune neurodegenerative diseases,infections,organ and bone marrow transplant rejection,and tumor response to therapy.Several of these molecular steps have been evaluated to date,including phosphatidylserine exposure at the extracellular faces of the plasma membrane,detected by protein such as annexin V,caspase activation in the intracellular compartment,detected by labeled enzyme substrates or inhibitors,etc.Therefore,the physician could much better use this information to optimize the therapy.It is consistent with the characteristics of physiological metabolism.It is proven that apoptosis imaging in vivo imaging is early,non-invasive and quantitative.

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备注/Memo

备注/Memo:
收稿日期:2009-06-20。
通讯作者:边艳珠(E-mail:yanzhubian@yahoo.com.cn)
更新日期/Last Update: 1900-01-01