[1]赵洪刚,董华,顾燕,等.早孕药物流产后动态观察血清性激素变化的临床价值[J].国际放射医学核医学杂志,2009,33(5):283-285.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.008]
　ZHAO Hong-gang,DONG Hua,GU Yah,et al.Dynamically observing the value of the changes of serum sex hormone levels of early pregnancy after drug-induced abortion[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):283-285.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.008]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第5期
页码:
283-285
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Dynamically observing the value of the changes of serum sex hormone levels of early pregnancy after drug-induced abortion
作者:
赵洪刚;  董华;  顾燕;  张遵城
天津医科大学第二医院核医学科, 300211
Author(s):
ZHAO Hong-gang;  DONG Hua;  GU Yah;  ZHA NG Zun-cheng
Department of Nuclear Medicine, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
关键词:
流产; 人工; 绒毛膜促性腺激素; β-亚单位; 人; 雌二醇; 孕酮
Keywords:
Abortion; induced; Chorionic gonadotropin; beta suhunit; human; Estradiol; Progesterone
DOI:
10.3760/cnla.j.issn.1673-4114.2009.05.008
摘要:
摘要:目的 探讨动态观察早孕药物流产孕妇血清β-人绒毛膜促性腺激素(β-HCG)、雌二醇(E)及孕酮(P)水平变化的临床价值。方法 对55例停经时间35~39 d、证实早孕而要求终止妊娠的孕妇给予米非司酮配伍米索前列醇,使用化学发光免疫分析法对服药前后外周血β-HCG、E及P水平动态监测,进行回顾性分析。结果 所有早孕妇女孕囊排出后7 d时β-HCG、E、P水平均明显降低(tβ-HCG=4.845,tE=7.655,tP=11.390,P<0.05)。孕囊排出后7 d时E和P水平迅速下降到卵泡期水平,14 d较7 d时雌二醇明显上升(tE=9.089,P<0.05);21 d较14 d时P有明显升高(tP=2.910,P<0.05)。结论 化学发光免疫分析法测定血清β-HCG、E和P水平可以间接评价米非司酮配伍米索前列醇药物流产的疗效,并预测药流后阴道出血时间是否延长,从而早期判断预后,为尽早给予临床干预提供依据。
Abstract:
Objective To observe the value of the changes of serum β-human chorionic gonadotropin(β-HCG),estradiol(E),progesterone(P)Levels of early pregnancy after drug-induced abortion dynamically.Methods Assessing 55 women proved pregnant by urine or blood HCG retrospecticly,who had terminated their pregnancy by mifepristonr and misoprostol.Meanwhile the serum levels of β-HCG,E,P were monitored dynamically.Results Among the 55 patients,the levels of β-HCG,E and P had significant decreased(tβ-HCG=4.845,tE=7.655,tP=11.390,P<0.01).On the 7th day,the levels of E and P decreased to the level of follicle phase.The level of E on the 14th day was higher than that of 7th day(tE=9.089,P<0.05); the level of P was higher than that of 14th day(tP=2.910,P<0.05).Conclusion Detecting the serum hormone’s levels after drug-induced abortion by chemiluminescent immunoassay,we can assess indirectly the value of administration of mifepristone and misoprostol,predict the prolonged vaginal bleeding after drug-induced abortion,and the outcome of the treatment,which determine wether need another curestage.

参考文献/References:

[1] 常玲,郭俊荣,咎荣华.药物流产过程中HCG,B超,组织病理与阴道流血的关系及处理医师进修杂志,2000,23(4):56.
[2] 乐杰.妇产科学5版.北京:人民卫生出版社,2000:431.
[3] 任连琴.米非司酮配伍米索前列醇终止10周至16周妊娠的临床观察与护理实用医技杂志,2007,14(2):238-239.
[4] 李春.米非司酮配伍米索前列醇终止早孕的效果观察实用临床医学,2007,8(1):70-71.
[5] 朱瑜.赵华英.陈丽.等.米非司酮配伍米索前列醇终止妊娠10-12周瘢痕子宫钳刮术中的应用.中国现代临床医学, 2007,6(12):45-46.

相似文献/References:

[1]刘义明,叶爱霞,钟娆霞,等.血清β-人绒毛膜促性腺激素、孕酮、雌二醇值对早期正常妊娠、妊娠流产和异位妊娠的诊断价值[J].国际放射医学核医学杂志,2009,33(2):102.[doi:10.3760/cma.j.issn.1673-4114.2009.02.012]
　LIU Yi-ming,YE Ai-xia,ZHONG Rao-xia,et al.Diagnostic value of serum β-human chorionic gonadotropin,progesterone and estradiol in early normal pregnancy, pregnancy abortion and ectopic pregnancy[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):102.[doi:10.3760/cma.j.issn.1673-4114.2009.02.012]

备注/Memo

备注/Memo:
收稿日期:2009-06-12。
通讯作者:赵洪刚(E-mail:zhaohonggangzhg@sina.com)
更新日期/Last Update: 1900-01-01