[1]邢宇,赵新明.放射性核素标记HER2亲和体分子探针精准诊疗的研究进展[J].国际放射医学核医学杂志,2016,40(2):139-144.[doi:10.3760/cma.j.issn.1673-4114.2016.02.011]
 Xing Yu,Zhao Xinming.Advances in radionuclide-labeled HER2 affibody molecular probes for precise diagnosis and treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):139-144.[doi:10.3760/cma.j.issn.1673-4114.2016.02.011]
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放射性核素标记HER2亲和体分子探针精准诊疗的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第2期
页码:
139-144
栏目:
出版日期:
2016-03-25

文章信息/Info

Title:
Advances in radionuclide-labeled HER2 affibody molecular probes for precise diagnosis and treatment
作者:
邢宇 赵新明
050011 石家庄, 河北医科大学第四医院核医学科
Author(s):
Xing Yu Zhao Xinming
Department of Nuclear Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
关键词:
受体表皮生长因子放射性核素显像亲和体分子
Keywords:
Receptor epidermal growth factorRadionuclide imagingAffibody molecules
DOI:
10.3760/cma.j.issn.1673-4114.2016.02.011
摘要:
人表皮生长因子受体2(HER2)亲和体分子因具有对靶组织亲和力高、特异性强、分子量小、制备简单、生物动力学特征良好等特点,近年来在肿瘤分子影像方面的研究中显示出了较好的临床应用前景。放射性核素标记HER2亲和体分子探针不仅可以进行肿瘤受体显像及疗效评价,还可以用于靶向治疗。笔者就目前放射性核素标记HER2亲和体分子探针精准诊疗的研究进展作简要综述。
Abstract:
Human epidermal growth factor receptor type 2(HER2) affibody molecules hold the advantage of high specificity and affinity, small size, simple synthesis, and excellent biological dynamics. It has been widely used in molecular imaging and treatment of tumor, with an eye towards clinical translation. The molecular probes of radionuclide-labeled HER2 affibody can not only be used in receptor imaging and response evaluation of tumor, but also in targeted therapy. This article reviewed the latest researches on radionuclide-labeled HER2 affibody.

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备注/Memo

备注/Memo:
收稿日期:2015-12-23。
基金项目:国家自然科学基金(81571702)
通讯作者:赵新明,Email:xinm_zhao@163.com
更新日期/Last Update: 1900-01-01