[1]袁卫红,罗志航,彭荣宗,等.肺癌与表皮生长因子及其受体关系的研究[J].国际放射医学核医学杂志,2006,30(5):261-263,267.
　YUAN Wei-hong,LUO Zhi-hang,PENG Rong-zong,et al.The study on the correlation between EGF, EGFR and lung carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(5):261-263,267.
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肺癌与表皮生长因子及其受体关系的研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第5期
页码:
261-263,267
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The study on the correlation between EGF, EGFR and lung carcinoma
作者:
袁卫红;  罗志航;  彭荣宗;  杨雷;  张怡
650101 昆明, 昆明医学院第二附属医院核医学科
Author(s):
YUAN Wei-hong;  LUO Zhi-hang;  PENG Rong-zong;  YANG Lei;  ZHANG Yi
Department of Nuclear Medicine, The Second Affiliated Hospital, Kunming Medicial College, Kunming 650101, China
关键词:
肺肿瘤; 表皮生长因子; 受体; 表皮生长因子
Keywords:
Lung neoplasms; Epidermal growth factor; Receptor;  epidermal growth factor
分类号:
R730.43
摘要:
目的 观察肺良性疾病、原发性肺癌患者表皮生长因子(EGF)及其受体(EGFR)在组织中不同表达及其与预后的关系。方法 采用用免疫组化(IHC)法检测患者EGFR的表达;用放射免疫分析(RIA)法测定患者EGF的动态变化,并对肺癌患者进行随访。结果 EGFR在非小细胞肺癌(NSCLC)中表达88%(80/91),在癌旁组织中(距肿瘤边缘3cm以内)表达64%(58/91),较肺良性疾病(10%,10/95)高,差异有显著性意义(t=4.0,P<0.01),而距肿瘤边缘6cm以远的正常肺组织表达12%(11/91),与肺良性疾病差异无显著性意义(t=28,P>0105);小细胞肺癌不表达EGFR。肺癌患者术前血中EGF较肺良性疾病高,术后明显下降。EGFR表达阳性的NSCLC患者,术前EGF较阴性组高,术后逐渐下降,复发前、复发后升高,接近术前水平;EGFR表达阳性的NSCLC患者,术后6、12、18、24个月复发率分别为10%、55%、70%、81%,而EGFR表达阴性的复发率分别是0、13%、37%、50%。结论 EGFR与肺癌预后关系密切。
Abstract:
Objective To detect and observe the different expression and the prognosis relation between epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in benign lung disease and primary lung carcinoma. Methods To detect EGFR by immunohistochemical (IHC) ABC method. To test and follow-up survey the changes of EGF in lung cancer patients by radioimmunoassay(RIA). Results The level of EGFR in non-small cell lung carcinoma (NSCLC) was 88% (80/91), in tissues (3 centimetres nearby tumor) was 64%(58/91), in benign lung disease was 10% (4/39) (t=4.73, P<0.01). The level of EGFR in normal lung tissues (6 centimetres nearby tumor) was 12%(11/91), but these was no significante difference with benign lung disease (t=2.8, P>0.05). EGFR was not tested in NSCLC. Before operation, the level of EGF in lung cancer patients was higher than that of benign lung patients, but it decreased after operation. The EGF in NSCLC with positive EGFR pre-operation was higher than that of negative EGFR, but it decreased post operation, while pre and post-recurrence it increased approaching the pre-operation level. NSCLC patients with positive EGFR, the recurrence rate was 16%, 55%, 70% and 81% a second time 6, 12, 18 and 24 months after operation, while the recurrence rate with negative EGFR was 0, 13%, 37% and 50%, respectively. Conclusions EGFR may play important action in the lung cancer prognosis.

参考文献/References:

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2 Chan SK,Gullick WJ,Hill ME,et al.Mutations of the epidermal growth factor receptor in non-small-cell lung cancer search and destroy.Eur J Cancer,2006,42(1):17-23.
3 Lee D.Phase Ⅱ data with ZD6474,a small-molecule kinase inhibtor of epidermal growth factor receptor and vascular endothelial growth factor receptor,in previously treated advanced non-small-cell lung cancer.Clin Lung Cancer,2005,7(2):89-91.
4 Dazzi H,Hasleton PS,Thatcher N,et al.Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer.Use of archival tissue and correlation of EGF-R with histology,tumour size,node status and survival.Br J Cancer,1989,59(5):746-749.
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备注/Memo

备注/Memo:
收稿日期:2006-03-21。
通讯作者:袁卫红,E-mail:yuantianhe@163.com
更新日期/Last Update: 1900-01-01