[1]麦卫平,张永林.能谱CT成像在肺癌诊断中的应用研究进展[J].国际放射医学核医学杂志,2016,40(1):77-81.[doi:10.3760/cma.j.issn.1673-4114.2016.01.015]
 Mai Weiping,Zhang Yonglin.Research progress of spectral imaging in the diagnosis of lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):77-81.[doi:10.3760/cma.j.issn.1673-4114.2016.01.015]
点击复制

能谱CT成像在肺癌诊断中的应用研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第1期
页码:
77-81
栏目:
出版日期:
2016-01-25

文章信息/Info

Title:
Research progress of spectral imaging in the diagnosis of lung cancer
作者:
麦卫平 张永林
030001 太原, 山西医科大学附属第二医院影像科
Author(s):
Mai Weiping Zhang Yonglin
Department of Radiology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
关键词:
肺肿瘤体层摄影术X线计算机能谱成像能谱曲线
Keywords:
Lung neoplasmsTomographyX-ray computedSpectral imagingSpectral curve
DOI:
10.3760/cma.j.issn.1673-4114.2016.01.015
摘要:
能谱成像是近年来CT成像领域的一项新技术,具有多参数、定量分析等成像特点,其主要技术包括物质分离、单能量图像、能谱曲线和有效原子序数测定。通过多种参数和分析工具的综合应用,能谱CT能够客观反映病变的组织特征,对确定病变的组织来源和范围、鉴别诊断等方面具有潜在价值。其在肺癌的筛查、肺结节的良恶性判定等方面的研究中也取得了初步成果,笔者就能谱CT的主要技术及其在肺癌诊断中的应用作一综述。
Abstract:
Spectral imaging is a new technique in the field of CT imaging in recent years,with many parameters,quantitative analysis of imaging characteristics,the main technology including material separation,single energy image,can measure the spectrum curve and the effective atomic number.Through the comprehensive application of various parameters and analysis tools,spectrum imaging can reflect the characteristics of lesions,and has potential value to determine the source and scope,differential diagnosis etc..The screening of lung cancer,the identifying of benign and malignant pulmonary nodules and other aspects of the study also achieved initial results.This article focuses on the spectrum technology and its application in diagnosis of lung cancer.

参考文献/References:

[1] She J,Yang P,Hong QY,et al.Lung cancer in China challenges and interventions[J].Chest,2013,143(4):1117-1126.DOI:10.1378/chest.11-2948.
[2] 张金山,吴兆红,邓咏梅,等.99mTc-MIBI联合99mTc-HL91乏氧显像对60例原发性肺癌的诊断评价[J].国际放射医学核医学杂志,2006,30(5):287-289.Zhang JS,Wu ZH,Deng YM.The diagnostic value of 99mTc-MIBI combined with 99mTc-HL9l hypoxia imaging in primary lung cancer[J].Int J Radiat Med Nucl Med,2006,30(5):287-289.
[3] Lin XZ,Miao F,Li JY,et al.High-Definition CT gemstone spectral imaging of the brain:initial results of selecting optimal monochromatic image for Beam-Hardening artifacts and image noise reduction[J].J Comput Assist Tomogr,2011,35(2):294-297.DOI:10.1097/RCT.0b013e3182058d5c.
[4] 林晓珠,沈云,陈克敏.CT能谱成像的基本原理与临床应用研究进展[J].中华放射学杂志,2011,45(8):798-800.DOI:10.3760/cma.j.issn.1005-1201.2011.08.028.Lin XZ,Shen Y,Chen KM.Spectral CT imaging:principle,clinical application and research[J].Chin J Radiol,2011,45(8):798-800.
[5] 刘爱连,沈云,董越,等.能谱CT临床应用图谱[M].北京:人民军医出版社,2012:18-19.Liu AL,Shen Y,Dong Y,et al.Atlas of Clinical Applications of Spectral CT[M].Beijing:People’s Military Medical Press,2012:18-19.
[6] Ferda J,Novák M,Mírka H,et al.The assessment of intracranial bleeding with virtual unenhanced imaging by means of dual-energy CT angiography[J].Eur Radiol,2009,19(10):2518-2522.DOI:10.1007/s00330-009-1495-2.
[7] Chandarana H,Godoy MC,Vlahos I,et al.Abdominal aorta:evaluation with Dual-Source Dual-Energy multidetector CT after endovascular repair of Aneurysms-Initial observations[J].Radiology,2008,249(2):692-700.DOI:10.1148/radiol.2492080359.
[8] Lv P,Lin XZ,Li J,et al.Differentiation of small hepatic hemangioma from small hepatocellular carcinoma:recently introduced spectral CT method[J].Radiology,2011,259(3):720-729.DOI:10.1148/radiol.11101425.
[9] Qu M,Ramirez-Giraldo JC,Leng S,et al.Dual-energy dual-source CT with additional spectral filtration can improve the differentiation of non-uric acid renal stones:an ex vivo phantom study[J].AJR Am J Roentgenol,2011,196(6):1279-1287.DOI:10.2214/AJR.10.5041.
[10] Doria-Rose VP,Marcus PM,Miller AB,et al.Does the source of death information affect cancer screening efficacy results?A study of the use of mortality review versus death certificates in four randomized trials[J].Clin Trials,2010,7(1):69-77.DOI:10.1177/1740774509356461.
[11] 胡兴和.宝石能谱CT在早期肺癌筛查中的应用价值[J].医疗卫生装备,2011,32(12):64-65,78.DOI:10.3969/j.issn.1003-8868.2011.12.026.Hu XH.Application value of gem energy spectrum CT for screening of early lung cancer[J].Chin Med Equip J,2011,32(12):64-65,78.
[12] Winer-Muram HT.The solitary pulmonary nodule[J].Radiology,2006,239(1):34-49.DOI:http://dx.doi.org/10.1148/radiol.2391050343.
[13] Poschenrieder F,Beyer L,Rehbock B,et al.Management of solid pulmonary nodules[J].Radiologe,2014,54(5):436-448.DOI:10.1007/s00117-013-2601-7.
[14] Park CM,Goo JM,Lee HJ,et al.Nodular ground-glass opacity at thin-section CT:histologic correlation and evaluation of change at follow-up[J].Radiographics,2007,27(2):391-408.DOI:10.1148/rg.272065061.
[15] Choromańska A,Macura KJ.Evaluation of solitary pulmonary nodule detected during computed tomography examination[J].Pol J Radiol,2012,77(2):22-34.
[16] 方亚军,黄召勤,凌春香,等.能谱技术在肺结节CT值定量测量中的实验研究[J].实用放射学杂志,2012,28(3):454-457.DOI:10.3969/j.issn.1002-1671.2012.03.034.Fang YJ,Huang ZQ,Ling CX,et al.Experimental study on quantitative measurement of CT attenuations of pulmonary Nodules with gemstone spectral imaging[J].J Pract Radiol,2012,28(3):454-457.
[17] 吴维,张进华,万维佳,等.能谱CT诊断孤立性肺结节/肿块的初步研究[J].放射学实践,2014,29(9):998-1002.DOI:10.13609/j.cnki.1000-0313.2014.09.005.Wu W,Zhang JH,Wan WJ,et al.The diagnostic value of spectral CT imaging in lung solitary nodule/mass[J].Radiologic Pract,2014,29(9):998-1002.
[18] 关牧娟.宝石能谱CT成像鉴别诊断孤立性肺结节性质的研究[D].郑州:郑州大学,2013.Guan MJ.Utility of Spectral Imaging in the Differentiation of Solitary Pulmonary Nodule:Preliminary Study[D].Zhengzhou:Zhengzhou University,2013.
[19] Subramanian J,Govindan R.Lung cancer in never smokers:a review[J].J Clin Oncol,2007,25(5):561-570.DOI:10.1200/JCO.2006.06.8015.
[20] Qiang JW,Zhou KR,Lu G,et al.The relationship between solitary pulmonary nodules and bronchi:multi-slice CT-pathological correlation[J].Clin Radiol,2004,59(12):1121-1127.DOI:10.1016/j.crad.2004.02.018.
[21] 林晓珠,李卫侠,朱延波,等.宝石能谱CT在肿瘤诊断中的初步应用[J].诊断学理论与实践,2010,9(2):155-160.Lin XZ,Li WX,Zhu YB,et al.Preliminary application of Gemstone Spectral Imaging(GSI)in the diagnosis of tumors[J].J Diagn Concepts Prac,2010,9(2):155-160.
[22] 王雪梅,石华,杨露露,等.能谱CT定量分析在鉴别诊断肺鳞癌与腺癌中的应用价值[J].宁夏医科大学学报,2013,35(4):415-418.DOI:10.3969/j.issn.1674-6309.2013.04.016.Wang XM,Shi H,Yang LL,et al.Value of spectral CT imaging in differentiating plumonary squamous cell carcinoma and adenocarcinoma[J].J Ningxia Med Univ,2013,35(4):415-418.
[23] 孟晓燕.能谱CT在肺癌病理分型及纵隔淋巴结转移评估中的初步应用研究[D].天津:天津医科大学,2014.Meng XY.Evaluation of lung cancer histologic classification and lymph nodes metastases:initial experience with spectral CT imaging[D].Tianjin:Tianjin Medical University,2014.
[24] Iskender I,Kadioglu SZ,Kosar A,et al.Is there any maximum standardized uptake value variation among positron emission tomography scanners for mediastinal staging in non-small cell lung cancer?[J].Interact Cardiovasc Thorac Surg,2011,12(6):965-969.DOI:10.1510/icvts.2010.258103.
[25] Tournoy KG,Keller SM,Annema JT.Mediastinal staging of lung cancer:novel concepts[J].Lancet Oncol,2012,13(5):e221-e229.DOI:10.1016/S1470-2045(11)70407-7.
[26] Iskender I,Kadioglu SZ,Cosgun T,et al.False-positivity of mediastinal lymph nodes has negative effect on survival in potentially resectable non-small cell lung cancer[J].Eur J Cardiothorac Surg,2012,41(4):874-879.DOI:10.1093/ejcts/ezr054.
[27] 刘金刚,刘亚,李丽新,等.CT能谱成像在诊断肿瘤淋巴结转移和肿瘤性质中的作用[J].中华放射学杂志,2011,45(8):731-735.DOI:10.3760/cma.j.issn.1005-1201.2011.08.006.Liu JG,Liu Y,Li LX,et al.Preliminary study of spectral CT imaging in the differential diagnosis of metastatic lymphadenopathy due to various tumors[J].Chin J Radiol,2011,45(8):731-735.
[28] 李明英,邓凯,张成琪.能谱CT在原发性肺癌纵隔淋巴结转移中的诊断价值[J].实用放射学杂志,2013,29(6):906-909.DOI:10.3969/j.issn.1002-1671.2013.06.011.Li MY,Deng K,Zhang CQ.Diagnostic value of spectrum CT in mediastinal lymph node metastasis of primary lung cancer[J].J Pract Radiol,2013,29(6):906-909.

相似文献/References:

[1]周玉祥,蓝博文,黄春榆,等.64排螺旋CT冠状动脉血管成像诊断冠状动脉-肺动脉瘘的应用价值[J].国际放射医学核医学杂志,2016,40(1):26.[doi:10.3760/cma.j.issn.1673-4114.2016.01.006]
 Zhou Yuxiang,Lan Bowen,Huang Chunyu,et al.Clinical value of coronary artery-pulmonary artery fistula revealed by 64-slice spiral CT coronary angiography[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):26.[doi:10.3760/cma.j.issn.1673-4114.2016.01.006]
[2]陈超坤,刘亮,傅飞先,等.囊性胸腺瘤和囊性畸胎瘤的影像学特征及鉴别诊断[J].国际放射医学核医学杂志,2016,40(1):31.[doi:10.3760/cma.j.issn.1673-4114.2016.01.007]
 Chen Chaokun,Liu Liang,Fu Feixian,et al.Imaging features and differential diagnosis of cystic thymoma and cystic teratoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):31.[doi:10.3760/cma.j.issn.1673-4114.2016.01.007]
[3]岳进,苏丽萍.全身MRI与PET/CT在淋巴瘤骨髓浸润诊断及预后中的作用[J].国际放射医学核医学杂志,2016,40(1):50.[doi:10.3760/cma.j.issn.1673-4114.2016.01.010]
 Yue Jin,Su Lipin.Function of whole-body MRI and PET/CT in the diagnosis and prognosis of lymphoma with bone marrow infiltration[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):50.[doi:10.3760/cma.j.issn.1673-4114.2016.01.010]
[4]张莹莹,王振光,孔艳.PET/CT显像在肺间质纤维化中的应用进展[J].国际放射医学核医学杂志,2016,40(1):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
 Zhang Yingying,Wang Zhenguang,Kong Yan.Application advancement on PET/CT in pulmonary interstitial fibrosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
[5]史文杰,孟召伟,谭建.基于Deauville标准探讨18F-FDG PET/CT在霍奇金淋巴瘤复发诊断中的应用价值[J].国际放射医学核医学杂志,2016,40(2):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
 Shi Wenjie,Meng Zhaowei,Tan Jian.Value of 18F-FDG PET/CT on diagnosis of Hodgkin lymphoma recurrence using Deauville criterion[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
[6]周翠屏,廖俊杰,何国华,等.原发性肠系膜巨大淋巴结增生症的MSCT表现与病理对照分析[J].国际放射医学核医学杂志,2016,40(3):175.[doi:10.3760/cma.j.issn.1673-4114.2016.03.003]
 Zhou Cuiping,Liao Junjie,He Guohua,et al.Primary mesenteric Castleman disease:MSCT findings with histopathologic correlation[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):175.[doi:10.3760/cma.j.issn.1673-4114.2016.03.003]
[7]张巧娜,刘汉东.上颌窦上皮-肌上皮癌的CT表现一例[J].国际放射医学核医学杂志,2016,40(3):237.[doi:10.3760/cma.j.issn.1673-4114.2016.03.015]
[8]尤阳,轩昂,张杰,等.淋巴瘤患者大脑静息葡萄糖代谢改变[J].国际放射医学核医学杂志,2016,40(4):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
 You Yang,Xuan Ang,Zhang Jie,et al.Changes in resting-state brain glucose metabolism in patients with lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
[9]王朋,崔邦平,代文莉,等.18F-FDG PET/CT在前列腺癌中的应用进展[J].国际放射医学核医学杂志,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
 Wang Peng,Cui Bangping,Dai Wenli,et al.Progress in the application of 18F-FDG PET/CT in prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
[10]李菲,黄俊星,张俊.18F-FDG PET/CT在食管癌中的临床应用[J].国际放射医学核医学杂志,2016,40(4):282.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
 Li Fei,Huang Junxing,Zhang Jun.The clinical application of 18F-FDG PET/CT in esophageal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):282.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
[11]张艳兰,孙琦婷,武萍,等.呼吸门控PET/CT对于肺癌放疗靶区勾画的指导[J].国际放射医学核医学杂志,2015,39(2):105.[doi:10.3760/cma.j.issn.1673-4114.2015.02.001]
 Zhang Yanlan,Sun Qiting,Wu Ping,et al.Guiding the target delineation in radiation therapy of lung cancer by respiratory gated PET/CT[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):105.[doi:10.3760/cma.j.issn.1673-4114.2015.02.001]
[12]张高潮,马丽,寇莹,等.99Tcm-tetrofosmin SPECT诊断肺部肿瘤的临床价值[J].国际放射医学核医学杂志,2015,39(4):303.[doi:10.3760/cma.j.issn.1673-4114.2015.04.007]
 Zhang Gaochao,Ma Li,Kou Ying,et al.Clinical value of 99Tcm-tetrofosmin SPECT in the diagnosis of lung neoplasms[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):303.[doi:10.3760/cma.j.issn.1673-4114.2015.04.007]
[13]付畅,史大鹏,徐俊玲,等.不同组织学类型肺癌患者大脑静息葡萄糖代谢改变研究[J].国际放射医学核医学杂志,2014,38(2):75.[doi:10.3760/cma.j.issn.1673-4114.2014.02.002]
 Fu Chang,Shi Dapeng,Xu Junling,et al.The preliminary study of brain glucose metabolism changes in patients with lung cancer of different histological types[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(1):75.[doi:10.3760/cma.j.issn.1673-4114.2014.02.002]
[14]杨心蕊,卫华,郝新忠,等.过敏性肺炎伴左肺动脉栓塞18F-FDGPET/CT误诊肺癌一例[J].国际放射医学核医学杂志,2014,38(2):135.[doi:10.3760/cma.j.issn.1673-4114.2014.02.014]
[15]胡丽丽,李小东,张雪宁,等.影像引导下125I粒子植入治疗肺癌的疗效分析[J].国际放射医学核医学杂志,2013,37(4):203.[doi:10.3760/cma.j.issn.1673-4114.2013.04.004]
 HU Li-li,LI Xiao-dong,ZHANG Xue-ning,et al.Efficacy of CT guided radioactive 125I seed implantation in the treatment of lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(1):203.[doi:10.3760/cma.j.issn.1673-4114.2013.04.004]
[16]杨小丰,居热提·阿扎提,曹务成,等.肺癌患者体重、血糖浓度和病灶大小对18F-FDG PET/CT病灶SUV的影响[J].国际放射医学核医学杂志,2013,37(4):211.[doi:10.3760/cma.j.issn.1673-4114.2013.04.006]
 YANG Xiao-feng,JURETI-Azhati,CAO Wu-cheng,et al.The effect of lung cancer patients’ weight, blood glucose concentration and lesion size of lung cancer on 18F-FDG PET/CT lesions SUV results[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(1):211.[doi:10.3760/cma.j.issn.1673-4114.2013.04.006]
[17]李乐保,彭翔,叶慧,等.18F-FDG PET-CT对周围型肺癌的诊断价值研究[J].国际放射医学核医学杂志,2010,34(4):209.[doi:10.3760/cma.j.issn.1673-4114.2010.04.005]
 LI Le-bao,PENG Xiang,YE Hui,et al.The diagnostic value of PET-CT on peripheral lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(1):209.[doi:10.3760/cma.j.issn.1673-4114.2010.04.005]
[18]朱晓珉,方文岩,陈军,等.CT导向下125I粒子植入治疗难治生肺癌的疗效观察[J].国际放射医学核医学杂志,2011,35(2):114.[doi:10.3760/cma.j.issn.1673-4114.2011.02.012]
 ZHU Xiao-min,FANG Wen-yan,CHEN Jun,et al.CT guided interstitial 125I seed implantation treatment of refractory lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(1):114.[doi:10.3760/cma.j.issn.1673-4114.2011.02.012]
[19]田亚东,袁卫红.影像学及肿瘤相关抗原在诊断肺癌中的应用[J].国际放射医学核医学杂志,2011,35(5):295.[doi:10.3760/cma.j.issn.1673-4114.2011.05.011]
 TIAN Ya-dong,YUAN Wei-hong.Application of imaging and tumor-associated antigen in the diagnosis of lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(1):295.[doi:10.3760/cma.j.issn.1673-4114.2011.05.011]
[20]王俊起,高硕,李彦生.18F-氟化钠PET和PET-CT诊断肺癌骨转移的对比研究[J].国际放射医学核医学杂志,2009,33(2):68.[doi:10.3760/cma.j.issn.1673-4114.2009.02.002]
 WANG Jun-qi,GAO Shuo,LI Yan-sheng.Comparison between 18F-NaF PET and PET-CT to detect bone metastases in patients with lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(1):68.[doi:10.3760/cma.j.issn.1673-4114.2009.02.002]

备注/Memo

备注/Memo:
收稿日期:2015-07-24;改回日期:。
通讯作者:张永林
更新日期/Last Update: 1900-01-01