[1]付畅,史大鹏,徐俊玲,等.不同组织学类型肺癌患者大脑静息葡萄糖代谢改变研究[J].国际放射医学核医学杂志,2014,38(2):75-79.[doi:10.3760/cma.j.issn.1673-4114.2014.02.002]
　Fu Chang,Shi Dapeng,Xu Junling,et al.The preliminary study of brain glucose metabolism changes in patients with lung cancer of different histological types[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(2):75-79.[doi:10.3760/cma.j.issn.1673-4114.2014.02.002]
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不同组织学类型肺癌患者大脑静息葡萄糖代谢改变研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第2期
页码:
75-79
栏目:
出版日期:
2014-03-25

文章信息/Info

Title:
The preliminary study of brain glucose metabolism changes in patients with lung cancer of different histological types
作者:
付畅;  史大鹏;  徐俊玲;  轩昂;  张杰
河南省人民医院核医学科, 郑州大学人民医院, 450003
Author(s):
Fu Chang;  Shi Dapeng;  Xu Junling;  Xuan Ang;  Zhang Jie
Department of Nuclear Medicine, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospotial, Zhengzhou 450003, China
关键词:
肺肿瘤; 脑葡萄糖代谢; 正电子发射断层显像术; 体层摄影术; X线计算机; 氟脱氧葡萄糖F18
Keywords:
Lung neoplasms; Brain glucose metabolism; Positron-emission tomography; Tomography; X-ray computed; Fluorodeoxyglucose F18
DOI:
10.3760/cma.j.issn.1673-4114.2014.02.002
摘要:
目的 探讨不同组织学类型肺癌患者大脑静息葡萄糖代谢改变特点。方法 回顾性分析100例未经治疗的原发性肺癌患者全身18F-FDG PET/CT检查资料。肺癌组织学类型均经穿刺或手术病理明确,根据不同组织学类型将患者分为腺癌(42例)、鳞癌(37例)、小细胞肺癌(21例)3组。将50名健康体检者作为对照,采用统计参数地形图分析软件分析每组患者PET脑代谢显像资料,采用两样本t检验比较3组患者脑代谢改变的差异。结果 3组患者脑PET显像均表现为区域性大脑静息葡萄糖代谢降低,主要分布在左侧额叶上中回及双侧颞叶上、中、下回,小细胞肺癌组还可见右侧顶下小叶及海马区受累。小细胞肺癌组低代谢脑区面积(体素数3848)大于腺癌组(体素数1436)(t=14.33,P<0.05)和鳞癌组(体素数1397)(t=10.07,P<0.05),腺癌组与鳞癌组之间差异无统计学意义(t=0.764,P>0.05).结论 肺癌患者大脑静息葡萄糖代谢改变与其组织学类型有一定相关性。脑代谢降低区多涉及精神情感功能区,PET脑显像有望为肺癌患者出现的精神情感障碍症状提供客观的分子影像学依据和可能的评价指标。
Abstract:
Objective To investigate the changes of resting brain glucose metabolism in patients with lung cancer of different histological types.Methods One hundred patients with primary untreated lung cancer were divided into three groups[adenocarcinoma group (42 cases),squamous cell carcinoma group (37 cases)and small-cell carcinoma group (21 cases)] based on histological types confirmed by biopsy or surgical pathology.Their whole body 18F-FDG PET/CT were retrospectively studied.The brain PET data of three groups were analyzed individually using statistical parametric mapping,with 50 healthy controls as comparison.Results The brain PET imaging in all of three lung cancer groups showed relative reduction in the regional cerebral resting glucose metabolism,and mainly distributed in left superior and middle frontal gyrus and the inferior,middle and superior frontal gyrus bilateral frontal lobe.Besides,the hypometabolic brain areas were also detected in the right inferior parietal lobule and hippocampal in the small cell carcinoma group.The total hypometabolic brain area in the small cell lung cancer group (voxel values 3848)was greater than those in the adenocarcinoma (voxel values 1436) (t=14.33,P<0.05)and the squamous cell carcinoma groups (voxel values 1397) (t=10.07,P<0.05)respectively,and there was no statistical difference with respect to the areas between the later two groups (t=0.764,P>0.05).Conclusions The resting brain glucose metabolic changes in lung cancer patients may be correlated to their histological types of lung cancer.The reduced metabolic regions in lung cancer patients involved in some functional regions related to the mood disorders.The brain metabolic changes hopefully provide molecular imaging basis and evaluation indicator for lung cancer patients with affective disorders.

参考文献/References:

[1] Pirl WF, Traeger L, Greer JA, et al. Depression, survival, and epidermal growth factor receptor genotypes in patients with metastatic non-small cell lung cancer[J]. Palliat Support Care, 2013, 11(3):223-229.
[2] Tashiro M, Kubota K, Itoh M, et ah Regional cerebral glucose metabolism of patients with malignant diseases in different clinical phases[J]. Med Sei Monit, 2001,7(2):226-232.
[3] Hsieh TC, Wu YC, Yen KY. Early changes in brain FDG metabolism during anticancer therapy in patients with pharyngeal cancer[J]. J Neuroimaging, 2013, 23(1):156-173.
[4] 倪建明,张追阳,黄钢.体部恶性肿瘤静息脑葡萄糖代谢改变与肿瘤类型的关系[J].临床放射学杂志,2012,31(5):627-631.
[5] 黄钢,左传涛.客观认识统计参数图评价脑功能影像的作用[J].中华核医学杂志,2008,28(1):1-2.
[6] Kumano H, Ida I, Oshima A, et al. Brain metabolic changes associated with predispotion to onset of major depressive disorder and adjustment disorder in cancer patients_a preliminary PET study[J]. J Psychiatric Res, 2007, 41(7):591-599.
[7] 苏亮,左传涛,管一晖,等.18F-FDG PET脑显像用于恶性肿瘤患者抑郁分析[J].中华核医学杂志,2005,25(3):159-161.
[8] Kim LS, Hwang HS, Jon DI, et al. Dysfunction of the neural network associated with sustained attention in cancer patients with clinically significant depressive symptoms[J]. Neurosci Lett, 2008, 447(1):1-6.
[9] Fujimoto T, Takeuchi K, Matsumoto T, et al. Metabolic changes in the brain of patients with late-onset major depression[J]. Psychiatry Res, 2008, 164(1):48-57.
[10] 于璟,唐一源.SPECT在抑郁症研究中的应用[J].国际放射医学核医学杂志,2007,31(1):13-16.
[11] Vos MS, Putter H, van Houwelingen HC, et al. Denial and social and emotional outcomes in lung cancer patients:the protective ef-fect of denial[J]. Lung Cancer, 2011, 72(1):119-124.
[12] Shimizu K, Nakaya N, Saito-Nakaya K, et al. Clinical biopsychosocial risk factors for depression in lung cancer patients:a compre-hensive analysis using data from the Lung Cancer Database Project[J]. Ann Oncol, 2012, 23(8):1973-1979.
[13] 林盟菲,黄钢,孙晓光,等.肺癌患者脑代谢改变与分期的关系[J].中国临床医学,2009,16(4):516-518.
[14] O’Keane V, Frodl T, Dinan TG. A review of Atypical depression in relation to the course of depression and changes in HPA axis organization[J]. Psychoneuroendocrinology, 2013, 37(10):1589-1599.
[15] 张剑戈,张方,黄喆憨,等.海马区脑功能连接网络随年龄变化的研究[J].中华核医学杂志,2009,29(6):391-394.
[16] Kratzer S, Mattusch C, Metzger MW. Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion.channels[J].Front Cell Neurosci,2013,91(7):10-33.

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备注/Memo

备注/Memo:
收稿日期:2013-08-06;改回日期:。
基金项目:河南省卫生科技重点攻关计划项目(2011020142)
通讯作者:徐俊玲(Email:xjlhzq@163.com)
更新日期/Last Update: 1900-01-01