[1]尤阳,轩昂,张杰,等.淋巴瘤患者大脑静息葡萄糖代谢改变[J].国际放射医学核医学杂志,2016,40(4):255-258.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
　You Yang,Xuan Ang,Zhang Jie,et al.Changes in resting-state brain glucose metabolism in patients with lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):255-258.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第4期
页码:
255-258
栏目:
出版日期:
2016-07-25

文章信息/Info

Title:
Changes in resting-state brain glucose metabolism in patients with lymphoma
作者:
尤阳;  轩昂;  张杰;  付畅;  孙萌萌;  徐俊玲
450000, 郑州大学人民医院PET/CT中心
Author(s):
You Yang;  Xuan Ang;  Zhang Jie;  Fu Chang;  Sun Mengmeng;  Xu Junling
PET/CT Center, the People’s Hospital of Zhengzhou University, Zhengzhou 450000, China
关键词:
淋巴瘤; 脑葡萄糖代谢; 正电子发射断层显像术; 体层摄影术;  X线计算机; 氟脱氧葡萄糖F18; 统计参数地形图
Keywords:
Lymphoma; Brain glucose metabolism; Positron-emission tomography; Tomography;  X-ray computed; Fluorodeoxyglucose F18; Statistical parametric mapping
DOI:
10.3760/cma.j.issn.1673-4114.2016.04.003
摘要:
目的 讨论静息状态下淋巴瘤患者脑葡萄糖代谢改变特点。方法 回顾性分析102例未经治疗的淋巴瘤患者头部18F-FDG PET/CT图像资料。其中霍奇金淋巴瘤15例、非霍奇金淋巴瘤87例，所有患者均经活检或骨髓穿刺证实。选取77名健康体检者作为对照，采用统计参数地形图软件分析102例淋巴瘤患者PET脑代谢的改变。结果 淋巴瘤患者18F-FDG PET/CT表现为多个脑区的葡萄糖代谢减低，主要包括双侧颞下回、双侧颞中回、双侧颞上回、双侧额上回、右侧额中回及右侧小脑。未见明显代谢增高的脑区。结论 淋巴瘤患者大脑静息葡萄糖代谢改变以区域性葡萄糖代谢减低为主，涉及的脑区包括精神情感功能区和免疫相关脑区。
Abstract:
Objective To explore the metabolic changes in the resting brain glucose of patients with lymphoma but without brain metastasis. Methods A total of 102 patients with histologically confirmed lymphoma without treatment underwent 18F-FDG PET/CT examination. The whole-body 18F-FDG PET/CT images of the patients were retrospectively analyzed. Fifteen patients suffered from Hodgkin’s lymphoma and 87 of them had non-Hodgkin’s lymphoma. Seventy-seven healthy subjects were included as controls for comparison. The metabolic changes in resting brain glucose of the 102 patients with lymphoma were analyzed using statistical parametric mapping software. Results Compared with the control group, hypometabolic brain areas in the patients with lymphoma were observed mainly in the bilateral superior, middle, inferior temporal gyri; bilateral superior frontal gyrus; right middle frontal gyrus; and right cerebellum. Hypermetabolic areas were not observed in our patients. Conclusions The reduced metabolic cerebral regions in the patients with lymphoma involved a number of functional regions related to mood disorder and immunity.

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备注/Memo

备注/Memo:
收稿日期:2016-4-3;改回日期:。
基金项目:河南省医学科技攻关项目（2011020142）
通讯作者:徐俊玲,Email:xjlhzq@163.com
更新日期/Last Update: 1900-01-01