[1]孙萌萌,付畅,史大鹏,等.不同分期肺腺癌患者大脑静息葡萄糖代谢改变研究[J].国际放射医学核医学杂志,2015,39(6):437-441,446.[doi:10.3760/cma.j.issn.1673-4114.2015.06.001]
　Sun Mengmeng,Fu Chang,Shi Dapeng,et al.Preliminary study of metabolic changes in brain glucose of patients with lung adenocarcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(6):437-441,446.[doi:10.3760/cma.j.issn.1673-4114.2015.06.001]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第6期
页码:
437-441,446
栏目:
出版日期:
2015-11-25

文章信息/Info

Title:
Preliminary study of metabolic changes in brain glucose of patients with lung adenocarcinoma
作者:
孙萌萌;  付畅;  史大鹏;  徐俊玲;  轩昂;  张杰
450003, 郑州大学人民医院(河南省人民医院)核医学科
Author(s):
Sun Mengmeng;  Fu Chang;  Shi Dapeng;  Xu Junling;  Xuan Ang;  Zhang Jie
Department of Nuclear Medicine, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospotial, Zhengzhou 450003, China
关键词:
脱氧葡萄糖 F18; 腺癌; 肺; 正电子发射断层显像术; 体层摄影术; X线计算机; 脑葡萄糖代谢; 统计参数地图
Keywords:
Fluorodeoxyglucose F18; Adenocarcinoma;  lung; Positron-emission tomography; Tomography;  X-ray computed; Brain glucose metabolism; Statistical parametric mapping
DOI:
10.3760/cma.j.issn.1673-4114.2015.06.001
摘要:
目的 探讨无脑部转移的不同分期肺腺癌患者大脑静息葡萄糖代谢改变特点及其关系。方法 回顾性分析120例组织学确诊为原发性肺腺癌患者的全身18F-FDG PET/CT检查资料,其中Ⅰ期患者为28例、Ⅱ期29例、Ⅲ期31例和Ⅳ期32例。50名健康体检者为对照组,分析Ⅰ、Ⅱ、Ⅲ、Ⅳ期肺腺癌患者脑葡萄糖代谢改变,并比较4组之间脑代谢改变的差异。结果 Ⅰ、Ⅱ、Ⅲ、Ⅳ期肺腺癌患者PET脑显像均表现区域性脑代谢减低,Ⅰ期累及脑区为左侧额上中回、右侧颞上中回、左侧颞中下回(体素数为681),Ⅱ期累及脑区为左侧额上中回、右侧颞上中回、左侧颞中下回(体素数为1258),Ⅲ期累及脑区为左侧额上中回、右侧颞上中回、左侧颞中下回、右侧顶下小叶(体素数为1810),Ⅳ期累及脑区为左侧额上中回、右侧颞上中下回、左侧颞上中下回、右侧顶下小叶、左侧前扣带回及右侧岛回(体素数为2910)。4组患者脑代谢减低区体素值差异具有统计学意义(F=25.444,P=0.0001),且随分期增加异常代谢脑区范围逐渐增大。结论 肺腺癌患者脑代谢减低区涉及多个与精神情感有关的功能脑区,且其脑代谢改变与肿瘤分期具有一定相关性。
Abstract:
Objective To investigate the metabolic changes in the resting brain glucose of patients with different stages of lung adenocarcinoma but without brain metastasis. Methods A total of 120 patients with primary untreated and histologically confirmed lung adenocarcinoma were divided into four groups based on TNM staging: stage I, 28 cases; stage II, 29 cases; stage III, 31 cases; and stage IV, 32 cases. The whole-body 18F-FDG PET/CT images of the patients were retrospectively analyzed. The brain PET data of the four groups were also examined individually and compared with those of the 50 healthy controls. Moreover, the metabolic changes in the brain glucose of the four groups were compared. Results The brain PET images showed relative reductions of the regional cerebral resting glucose metabolism of all the groups. In the stage I group, the reductions were mainly observed in the left superior-middle frontal, right superior-middle temporal, and left middle-inferior temporal gyrus. The total voxel value for this group was 681. The reductions in stage II group were evident in the left superior-middle frontal, right superior-middle temporal, and left middle-inferior temporal gyrus. The total voxel value for the stage II group was 1258. In the stage III group, reductions were evident in the left superior-middle frontal, right superior-middle temporal, left middle-inferior temporal gyrus, and right inferior parietal lobule. The total voxel value for the stage III group was 1810. In the stage IV group, reductions were evident in the left superior-middle frontal, right superior-middle-inferior temporal, left superior-middle-inferior temporal gyrus, right inferior parietal lobule, left anterior cingulated, and right insula gyrus. The total voxel value for the stage IV group was 2910. The four groups showed significantly different voxel values in their hypometabolic brain area(F=25.444, P=0.000 1), and the ranges expanded with tumor stage progression. Conclusions The reduced metabolic cerebral regions in lung adenocarcinoma patients involved a number of functional regions related to mood disorders. The ranges of the metabolic changes in the resting brain glucose in lung adenocarcinoma patients were closely correlated to different tumor stages.

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备注/Memo

备注/Memo:
收稿日期:2015-3-20。
基金项目:河南省卫生科技重点攻关计划项目(2011020142)
通讯作者:徐俊玲,Email:xjlhzq@163.com
更新日期/Last Update: 1900-01-01