[1]郑玉民,王自正,王峰,等.以表皮生长因子受体为靶点的肿瘤分子靶向治疗[J].国际放射医学核医学杂志,2007,31(1):21-25.
 ZHENG Yu-min,WANG Zi-zheng,WANG Feng,et al.Epidermal growth factor receptor targeted molecularly therapies of cancers[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):21-25.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第1期
页码:
21-25
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Epidermal growth factor receptor targeted molecularly therapies of cancers
作者:
郑玉民1 王自正2 王峰2 范我1
1. 215123 苏州, 苏州大学放射医学与公共卫生学院基础核医学教研室;
2. 210006 苏州, 南京医科大学附属南京第一医院核医学科
Author(s):
ZHENG Yu-min1 WANG Zi-zheng2 WANG Feng2 FAN Wo1
1. Department of Basic Nuclear Medicine, School of Radiation Medicine and Public Health, Soochow University, Suzhou 215123, China;
2. Department of Nuclear Medcine, Nanjing First Hospital affiliated, Nanjing Medical University, Nanjing 210006, China
关键词:
受体表皮生长因子肿瘤
Keywords:
Receptor epidermal growth factorNeoplasms
分类号:
R817.4
摘要:
表皮生长因子受体(EGFR)是多种肿瘤发展和生长过程的重要因素,EGFR信号转导系统在肿瘤细胞的增殖、血管形成、转移以及细胞凋亡抵抗中起关键作用。最近,抗EGFR单克隆抗体和EGFR.酪氨酸激酶抑制剂已经作为治疗EGFR阳性肿瘤的新方法进行临床应用,并且在对晚期和化疗耐药肿瘤的临床试验中表现出活性。本文综述了3类针对EGFR的靶分子药物。
Abstract:
Epidermal growth factor receptor (EGFR) has been known to be a significant factor in the development and growth of many types of cancers. It is now accepted that the EGFR signal transduction net work plays an important role in multiple tumorigenic processes, contributing to cancercell proliferation, angiogenesis, and metastasis, as well as protection from apoptosis. Recently, EGFR monoclonal antibodies(McAb) and epidermal growth factor receptor-tyrosine kinase (EGFR-TK) inhibitors have been validated as new treatment approach for those EGFR-positive cancers and have shown activity aginst advanced, chemofractory cancers in clinical trials. This article focuses on three EGFR targeted molecularly therapies of cancers.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2005-10-28。
通讯作者:郑玉民,E-mail:yuminzheng1981@yahoo.com.cn
更新日期/Last Update: 1900-01-01