[1]孙芳芳,张欣.uPAR放射性核素靶向显像研究进展[J].国际放射医学核医学杂志,2016,40(3):230-234.[doi:10.3760/cma.j.issn.1673-4114.2016.03.013]
 Sun Fangfang,Zhang Xin.Research progress of uPAR-targeted nuclear imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):230-234.[doi:10.3760/cma.j.issn.1673-4114.2016.03.013]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第3期
页码:
230-234
栏目:
出版日期:
2016-05-25

文章信息/Info

Title:
Research progress of uPAR-targeted nuclear imaging
作者:
孙芳芳 张欣
116011, 大连医科大学附属第一医院核医学科
Author(s):
Sun Fangfang Zhang Xin
Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
关键词:
放射性核素显像尿纤溶酶原激活物靶向显像
Keywords:
Radionuclide imagingUrinary plasminogen activatorTargeted imaging
DOI:
10.3760/cma.j.issn.1673-4114.2016.03.013
摘要:
尿激酶型纤溶酶原激活物及其特异性受体(uPA/uPAR)系统是肿瘤侵袭、转移和血管生成的核心环节之一,且与肿瘤的不良预后密切相关。检测肿瘤组织中uPA/uPAR表达水平及其随病情的变化情况,对于肿瘤预后判断、治疗方案的选择与疗效评价意义重大。放射性核素分子靶向显像方法在靶向受体表达水平测定上具有独特的优势,近来年医学研究者使用多种放射性核素标记uPAR的特异性配体进行了动物显像研究,并于2015年首次用于人体显像。笔者就近年来uPAR放射性核素靶向显像的研究进展作一综述。
Abstract:
Urokinase plasminogen activator(uPA) and urokinase plasminogen activator receptor(uPAR) system play an important role in the process of cancer invasion, metastasis and angiogenesiss, and it is closely associated with poor prognosis of tumors. Evaluate of uPAR expression level in the tumor cell is very significant for cancer prognosis, selection and assement the therapy. Molecular targeted nuclear imaging has unique advantage in testing receptor expression, several research group labeled uPAR specially ligands with different radionuclides for imaging uPAR. The first human uPAR imaging has taken in 2015. This article reviewed the research progress of uPAR-targeted molecular nuclear imaging in recent years.

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备注/Memo

备注/Memo:
收稿日期:2016-01-11
基金项目:辽宁省自然科学基金(2013023017)
通讯作者:张欣,Email:zhhw2000@126.com
更新日期/Last Update: 1900-01-01