[1]安淑娴,宋少莉,黄钢.放射性核素标记的凋亡显像剂的研究进展[J].国际放射医学核医学杂志,2015,39(6):470-477.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
　An Shuxian,Song Shaoli,Huang Gang.Recent advances in apoptosis imaging using radionuclide-labeled tracers[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(6):470-477.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
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放射性核素标记的凋亡显像剂的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第6期
页码:
470-477
栏目:
出版日期:
2015-11-25

文章信息/Info

Title:
Recent advances in apoptosis imaging using radionuclide-labeled tracers
作者:
安淑娴;  宋少莉;  黄钢
200127, 上海交通大学医学院附属仁济医院核医学科
Author(s):
An Shuxian;  Song Shaoli;  Huang Gang
Department of Nuclear Medicine, RenJi Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
关键词:
细胞凋亡; 分子探针; 放射性核素显像; 正电子发射断层显像术; 体层摄影术; 发射型计算机; 单光子
Keywords:
Apoptosis; Molecular probes; Radionuclide imaging; Positron-emission tomography; Tomography;  emission-computed;  single-photon
DOI:
10.3760/cma.j.issn.1673-4114.2015.06.008
摘要:
细胞凋亡存在于多种病理过程中,包括神经系统变性疾病、缺血性损伤、自身免疫性疾病和多种肿瘤等。凋亡检测的可视化对疾病的诊断、新的治疗方法的开发与疗效评价具有重要意义。传统的凋亡检测方法包括光学显微镜观察、原位末端标记法分析、流式细胞仪检测等,但其侵入性方式限制了之后的随访研究。而活体内凋亡显像有助于无创观察、直观了解凋亡发生的体内过程。PET与SPECT的发展,以及新的针对靶点的放射性核素标记显像剂的合成,使核医学进入了分子影像学的新时代。近年来,细胞凋亡PET与SPECT显像剂的研发应用,使活体内无创PET与SPECT检测细胞凋亡成为现实。笔者主要介绍用于在体凋亡显像的放射性标记探针及其最新研究应用进展。
Abstract:
Apoptosis or programmed cell death is an important form of cell death. Apoptosis is involved in numerous human pathological conditions, such as neurodegenerative diseases, ischemic damage, autoimmune disorders, and many types of cancer. Visualization of apoptosis is enormously beneficial in clinical diagnosis, development of new therapies, and therapeutic evaluation. The traditional methods of apoptosis detection include optical microscopy, TdT-mediated-dUTP nick end labeling analysis, and flow cytometry. However, these invasive techniques restrict the conduct of follow-up studies. Apoptosis imaging in living subjects has contributed to nondestructive observation and in understanding the biological process of apoptosis. The developments in PET and SPECT technologies, including the synthesis of targeted radionuclide tracers, led nuclear medicine into a new era of molecular imaging. The development and application of PET and SPECT as apoptosis imaging probes rendered the non-invasive detection of apoptosis in vivo a reality. This article reviewed the recent advances in apoptosis imaging using radionuclide-labeled tracers.

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备注/Memo

备注/Memo:
收稿日期:2015-7-9。
通讯作者:宋少莉,Email:shaoli-song@163.com
更新日期/Last Update: 1900-01-01