[1]李帅,李剑明.动脉粥样硬化易损斑块放射性核素标记分子探针的研究进展[J].国际放射医学核医学杂志,2015,39(1):80-84.[doi:10.3760/cma.j.issn.1673-4114.2015.01.017]
 Li Shuai,Li Jianming.Research progress of molecular probes labeled with radionuclide for imaging of atherosclerosis vulnerable plaque[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):80-84.[doi:10.3760/cma.j.issn.1673-4114.2015.01.017]
点击复制

动脉粥样硬化易损斑块放射性核素标记分子探针的研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第1期
页码:
80-84
栏目:
出版日期:
2015-01-25

文章信息/Info

Title:
Research progress of molecular probes labeled with radionuclide for imaging of atherosclerosis vulnerable plaque
作者:
李帅 李剑明
天津医科大学心血管病临床学院 泰达国际心血管病医院核医学科, 天津, 300457
Author(s):
Li Shuai Li Jianming
Department of Nuclear Medicine, TEDA International Cardiovascular Hospital, Tianjin Medical University Cardiovascular Clinical Institute, Tianjin 300457, China
关键词:
动脉粥样硬化放射性同位素分子探针斑块
Keywords:
AtherosclerosisRadioisotopesMolecular probesPlaque
DOI:
10.3760/cma.j.issn.1673-4114.2015.01.017
摘要:
动脉粥样硬化易损斑块破裂及随后发生的血栓形成和心肌坏死是急性冠状动脉(简称冠脉)事件发生的病理基础,急性冠脉事件的发生危险主要取决于易损斑块的组成成分而不是血管的狭窄程度。易损斑块具有如下特征:纤维帽较薄、炎性细胞浸润、细胞凋亡、斑块内出血及新生微血管生成。以凋亡细胞、巨噬细胞、氧化低密度脂蛋白、基质金属蛋白酶、组织因子、αvβ3整合素和微钙化为靶向的放射性核素标记分子探针已用于易损斑块的诊断研究,并表现出潜在的临床应用前景。
Abstract:
The spontaneous rupture of vulnerable atherosclerotic plaques and subsequent thrombus formation and myocardial necrosis are currently recognized as the primary mechanisms of acute coronary events. The dangerous of acute coronary events is mainly determined by plaque’s components, not by degree of luminal obstruction. Vulnerable plaque is characterized by a thin fibrous cap, accumulation of inflammatory cells, apoptosis, intraplaque hemorrhage, and revascularization. Several radionuclide probes target including apoptosis, macrophages, oxidized low density lipoprotein, matrix metalloproteinase, tissue factor, avβ3 integrin and microcalcification have shown the potential to detect the rupture-prone atherosclerotic plaque in vivo.

参考文献/References:

[1] Davies MJ.The pathophvsiology of acute coronary svndromes[J].Heart,2000,83(3):361-366.
[2] 张艳容.动脉粥样硬化斑块显像研究进展[J].国外医学:放射医学核医学分册,2004,28(3):109-113.
[3] Sadeghi MM,Glover DK,Lanza GM,et al.Imaging atherosclerosis and vulnerable plaque[J].J Nucl Med,2010,51(Suppl 1):51S-65.
[4] Temma T,Saji H.Radiolabelled probes for imaging of atheroscle-rotic plaques[J].Am J Nucl Med Mol Imaging,2012,2(4):432-447.
[5] Dachary-Prigent J,Freyssinet JM,Pasquet JM,et al.Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation:a flow cytometry study showing a role for free sulfhydryl groups[J].Blood,1993,81(10):2554-2565.
[6] Kolodgie FD,Petrov A,Virmani R,et al.Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V:a technique with potential for noninvasive imaging of vulnera-ble plaque[J].Circulation,2003,108(25):3134-3139.
[7] Kietselaer BL,Reutelingsperger CP,Heidendal GA,et al.Noninva-sive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis[J].N Engl J Med,2004,305(14):1472-1473.
[8] Rudd JH,Warburton EA,Fryer TD,et al.Imaging atherosclerotic plaque inflammation with[18F]-fluorodeoxyglucose positron emis-sion tomography[J].Circulation,2002,105(23):2708-2711.
[9] Wykrzykowska J,Lehman S,Williams G,et al.Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbo-hydrate,high-fat preparation[J].J Nucl Med,2009,50(4):563-568.
[10] Tahara N,Kai H,Ishibashi M,et al.Simvastatin attenuates plaque inflammation:evaluation by fluorodeoxyglucose positron emission tomography[J].J Am Coll Cardiol,2006,48(9):1825-1831.
[11] Lee SJ,On YK,Lee EJ,et al.Reversal of vascular 18F-FDG uptake with plasma high-density lipoprotein elevation by atherogenic risk reduction[J].J Nucl Med,2008,49(8):1277-1282.
[12] Laitinen IE,Luoto P,Nagren K,et al.Uptake of 11C-choline in mouse atherosclerotic plaques[J].J Nucl Med,2010,51(5):798-802.
[13] Kato K,Schober O,Ikeda M,et al.Evaluation and comparison of 11C-choline uptake and calcification in aortic and common carotid arterial walls with combined PET/CT[J].Eur J Nucl Med Mol Imag-ing,2009,36(10):1622-1628.
[14] Visse R,Nagase H.Matrix metalloproteinases and tissue inhibitorsof metalloproteinases:structure,function,and biochemistry[J].Circ Res,2003,92(8):827-839.
[15] Brown DL,Hibbs MS,Kearney M,et al.Identification of 92-kD gelatinase in human coronary atheros clerotic lesions.Association of active enzyme synthesis with unstable angina[J].Circulation,1995,91(8):2125-2131.
[16] Rajavashisth TB,Xu XP,Jovinge S,et al.Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques:evidence for activation by proinflammatory mediators[J].Circula-tion,1999,99(24):3103-3109.
[17] Ohshima S,Petrov A,Fujimoto S,et al.Molecular imaging of matrix metalloproteinase expression in atherosclerotic plaques of mice de-ficient in apolipoprotein e or low-density-lipoprotein receptor[J].J Nucl Med,2009,50(4):612-617.
[18] Langer HF,Haubner R,Pichler BJ,et al.Radionuclide imaging:a molecular key to the atherosclerotic plaque[J].J Am Coll Cardiol,2008,52(1):1-12.
[19] Haider N,Hartung D,Fujimoto S,et al.Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclero-sis:molecular imaging facilitates understanding of pathogenesis[J].J Nucl Cardiol,2009,16(5):753-762.
[20] Ohshima S,Fujimoto S,Petrov A,et al.Effect of an antimicrobial a-gent on atherosclerotic plaques:assessment of metalloproteinase activity by molecular imaging[J].J Am Coll Cardiol,2010,55(12):1240-1249.
[21] Witztum JL,Steinberg D.Role of oxidized low density lipoprotein in atherogenesis[J].J Clin Invest,1991,88(6):1785-1792.
[22] Gerrity RG.The role of the monocyte in atherogenesis:I.Transi-tion of blood-borne monocytes into foam cells in fatty lesions[J].Am J Pathol,1981,103(2):181-190.
[23] Kugiyama K,Kerns SA,Morrisett JD,et al.Impairment of endothe-lium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins[J].Nature,1990,344(6262):160-162.
[24] Ishino S,Mukai T,Kuge Y,et al.Targeting of lectin like oxidizedlow-density lipoprotein receptor 1(LOX-1) with 99mTc-labeled anti-LOX-1 antibody:potential agent for imaging of vulnerable plaque[J].J Nucl Med,2008,49(10):1677-1685.
[25] Moons AH,Levi M,Peters RJ.Tissue factor and coronary artery dis-ease[J].Cardiovasc Res,2002,53(2):313-325.
[26] Ardissino D,Merlini PA,Bauer KA,et al.Thrombogenic potential of human coronary atherosclerotic plaques[J].Blood,2001,98(9):2726-2729.
[27] Jeanpierre E,Le Tourneau T,Six I,et al.Dietary lipid lowering modifies plaque phenotype in rabbit atheroma after angioplasty:a potential role of tissue factor[J].Clrculation,2003,108(14):1740-1745.
[28] Temma T,Ogawa Y,Kuge Y,et al.Tissue factor detection for se-lectively discriminating unstable plaques in an atherosclerotic rab-bit model[J].J Nucl Med,2010,51(12):1979-1986.
[29] Schmidt AM,Yan SD,Brett J,et al.Regulation of human mononu-clear phagocyte migration by cell surface-binding proteins for ad-vanced glycation end products[J].J Clin Invest,1993,91(5):2155-2168.
[30] Cipollone F,Iezzi A,Fazia M,et al.The receptor RAGE as a pro-gression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques:role of glycemic control[J].Circulation,2003,108(9):1070-1077.
[31] Johnson LL,Tekabe Y,Kollaros M,et al.Imaging RAGE expression in atherosclerotic plaques in hyperlipidemic pigs[J].EJNMMI Res,2014,4:26.
[32] Virmani R,Kolodgie FD,Burke AP,et al.Atherosclerotic plaque progression and vulnerability to rupture:angiogenesis as a source of intraplaque hemorrhage[J].Arterioscler Thromb Vasc Biol,2005,25(10):2054-2061.
[33] Antonov AS,Kolodgie FD,Munn DH,et al.Regulation of macrophage foam cell formation by αvβ3 integrin:potential role in human atherosclerosis[J].Am J Pathol,2004,165(1):247-258.
[34] Laitinen I,Saraste A,Weidl E,et al.Evaluation of αvβ3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice[J].Circ Cardiovasc Imaging,2009,2(4):331-338.
[35] Beer AJ,Pelisek J,Heider P,et al.PET/CT imaging of integrin αvβ3 expression in human carotid atherosclerosis[J].JACC Cardio-vasc Imaging,2014,7(2):178-187.
[36] Motoyama S,Kondo T,Sarai M,et al.Multislice computed tomo-graphic characteristics of coronary lesions in acute coronary syn-dromes[J].J Am Coll Cardiol,2007,50(4):319-326.
[37] Huang H,Virmani R,Younis H,et al.The impact of calcification on the biomechanical stability of atherosclerotic plaques[J].Circu-lation,2001,103(8):1051-1056.
[38] Joshi NV,Vesey AT,Williams MC,et al.18F-fluoride positron emis-sion tomography for identifi cation of ruptured and high-risk coro-nary atherosclerotic plaques:a prospective clinical trial[J].Lancet,2014,383(9918):705-713.

相似文献/References:

[1]拓飞,张庆,张京,等.2014年度全国放射性核素γ能谱分析质量控制比对[J].国际放射医学核医学杂志,2015,39(5):401.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 011]
 tuo fei,zhang qing,zhang jing,et al.nationwide intercomparison for radionuclide analyses through γ-spectrometry method in 2014[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):401.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 011]
[2]肖林林,金问森,张江虹,等.电离辐射诱发动脉粥样硬化的研究进展[J].国际放射医学核医学杂志,2015,39(6):493.[doi:10.3760/cma.j.issn.1673-4114.2015.06.012]
 Xiao Linlin,Jin Wensen,Zhang Jianghong,et al.Research progress of radiation induced atherosclerosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):493.[doi:10.3760/cma.j.issn.1673-4114.2015.06.012]
[3]刘纯宝,兰晓莉,张永学.粥样硬化易损斑块传统影像与分子影像检测与评价现状[J].国际放射医学核医学杂志,2014,38(2):101.[doi:10.3760/cma.j.issn.1673-4114.2014.02.008]
 Liu Chunbao,Lan Xiaoli,Zhang Yongxue.Current situation of detection and evaluation for atherosclerosis vulnerable plaque by conventional imaging and molecular imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(1):101.[doi:10.3760/cma.j.issn.1673-4114.2014.02.008]
[4]段钰,李斌,高卉,等.神经内分泌肿瘤PET/CT的应用现状与进展[J].国际放射医学核医学杂志,2013,37(3):186.[doi:10.3760/cma.j.issn.1673-4114.2013.03.014]
 DUAN Yu,LI Bin,GAO Hui,et al.Application status and progress of PET/CT in neuroendocrine tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(1):186.[doi:10.3760/cma.j.issn.1673-4114.2013.03.014]
[5]彭武和,程静,曹庆东.核素肺通气/灌注显像在肺栓塞诊断中的现状及进展[J].国际放射医学核医学杂志,2012,36(2):80.[doi:10.3760/cma.j.issn.1673-4114.2012.02.005]
 PENG Wu-he,CHENG Jing,CAO Qing-dong.Present situation and development of the nuclide lung ventilation/perfusion imaging in diagnosis of lung embolim[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(1):80.[doi:10.3760/cma.j.issn.1673-4114.2012.02.005]
[6]陈红红,白光.《人体体表放射性核素污染处理规范》解读[J].国际放射医学核医学杂志,2012,36(4):200.[doi:10.3760/cma.j.issn.1673-4114.2012.04.001]
 CHEN Hong-hong,BAI Guang.Explanation of Specifwation of Decontamination for Radionuclides Contaminated Human Wound and Skin[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(1):200.[doi:10.3760/cma.j.issn.1673-4114.2012.04.001]
[7]刘庆芬,武权,樊体强,等.《放射性核素摄入量及内照射剂量估算规范》解读[J].国际放射医学核医学杂志,2012,36(4):214.[doi:10.3760/cma.j.issn.1673-4114.2012.04.005]
 LIU Qing-fen,WU Quan,FAN Ti-qiang,et al.Explanation of Specification for Assessments of Intakes and Internal Doses of Radionuclides[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(1):214.[doi:10.3760/cma.j.issn.1673-4114.2012.04.005]
[8]张富海,孟召伟,谭建.肺癌的放射性核素分子靶向治疗[J].国际放射医学核医学杂志,2012,36(3):145.[doi:10.3760/cma.j.issn.1673-4114.2012.03.005]
 ZHANG Fu-hai,MENG Zhao-wei,TAN Jian.Radionuclide molecular target therapy for lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(1):145.[doi:10.3760/cma.j.issn.1673-4114.2012.03.005]
[9]侯朝华,常颖欧,魏健,等.多层螺旋CT血管造影术诊断动脉粥样硬化性肾动脉狭窄的价值[J].国际放射医学核医学杂志,2011,35(5):307.[doi:10.3760/cma.j.issn.1673-4114.2011.05.013]
 HOU Zhao-hua,CHANG Ying-ou,WEI Jian,et al.Evaluation of atherosclerotic renal artery stenosis by multi-slice CT angiography[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(1):307.[doi:10.3760/cma.j.issn.1673-4114.2011.05.013]
[10]冯彦林,袁建伟,余丰文,等.18F-氟脱氧葡萄糖PET-CT诊断主动脉壁粥样硬化斑块的价值探讨[J].国际放射医学核医学杂志,2007,31(2):83.
 FENG Yan-lin,YUAN Jian-wei,YU Feng-wen,et al.Explore the vaule of 18F-fluorodeoxyglucose PET-CT imaging in atherosclerotic plaques of aorta wall[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):83.

备注/Memo

备注/Memo:
收稿日期:2014-10-27。
通讯作者:李剑明,Email:ichljm@163.com
更新日期/Last Update: 1900-01-01