[1]张富海,孟召伟,谭建.肺癌的放射性核素分子靶向治疗[J].国际放射医学核医学杂志,2012,36(3):145-148.[doi:10.3760/cma.j.issn.1673-4114.2012.03.005]
 ZHANG Fu-hai,MENG Zhao-wei,TAN Jian.Radionuclide molecular target therapy for lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(3):145-148.[doi:10.3760/cma.j.issn.1673-4114.2012.03.005]
点击复制

肺癌的放射性核素分子靶向治疗(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第3期
页码:
145-148
栏目:
临床核医学
出版日期:
2012-05-25

文章信息/Info

Title:
Radionuclide molecular target therapy for lung cancer
作者:
张富海 孟召伟 谭建
天津医科大学总医院核医学科, 天津 300052
Author(s):
ZHANG Fu-hai MENG Zhao-wei TAN Jian
Department of Nuclear Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China
关键词:
肿瘤放射性同位素近距离放射疗法钠/碘转运体
Keywords:
Lung neoplasmsRadioisotopesBrachylherapySodium/iodide transporter
DOI:
10.3760/cma.j.issn.1673-4114.2012.03.005
摘要:
肺癌严重危害民众的生命和健康,目前国内外肺癌的发病率和病死率还在不断上升。在城市中,肺癌的病死率占男性恶性肿瘤患者病死率的38%,占女性恶性肿瘤患者病死率的16%,均居首位。尤其是非小细胞肺癌的治疗效果多年来一直没有显著提高。近年来,随着医学分子生物学技术和理论的发展以及对肺癌发病机制认识的不断深人,转染钠/碘转运体基因及分子靶向药物介导的肺癌放射性核素治疗成为治疗晚期肺癌新的研究方向。
Abstract:
Lung cancer harms people’s health or even lives severely. Currently, the morbidity and mortality of lung cancer are ascending all over the world. Accounting for 38.08% of malignant tumor caused death in male and 16% in female in cities, ranking top in both sex. Especially, the therapy of non-small cell lung cancer has not been obviously improved for many years. Recently, sodium/iodide transporter gene trans-fection and the therapy of molecular target drugs mediated radionuclide are being taken into account and become the new research directions in treatment of advanced lung cancer patients with the development of technology and theory for medical molecular biology and the new knowledge of lung cancer’s pathogenesis.

参考文献/References:

[1] Van Meerbeeck JP,Fennell DA,De Ruysscher DK.Small-cell lung cancer.Lancet,2011,378(9804):1741-1755.
[2] Patel AR,Wedzicha JA,Hurst JR.Reduced lung-cancer mortality with CT screening.N Engl J Med,2011,365(21):2035.
[3] Sox HC.Better evidence about screening for lung cancer.N Engl J Med,2011,365(5):455-457.
[4] Heuvers ME,Stricker BH,Aerts JG.Generalizing lung-cancer screening results.N Engl J Med,2012,366(2):192-193.
[5] Xie Y,Minna JD.A lung cancer molecular prognostic test ready for prime time.Lancet,2012,379(9818):785-787.
[6] Yasuda H,Kobayashi S,Costa DB.EGFR exon 20 insertion muta-tions in non-small-cell lung cancer:preclinical data and clinical implications.Lancet Oncol,2012,13(1):e23-3 t.
[7] Wang W,Li Q,Takeuchi S,et al.Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cancer.Clin Cancer Res,2012,18(6):1663-1671.
[8] Su KY,Chen HY,Li KC,et al.Pretreatment epidermal growthfactor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer.J Clin Oneol,2012,30(4):433-440.
[9] Politi K,Lynch TJ.Two sides of the same coin:EGFR exon 19 deletions and insertions in lung cancer.Clin Cancer Res,2012,18(6):1490-1492[2012-03-15].http://www.ncbi.nlm.nih.gov/pubmed?term=Politi%20K%2C%20Lynch%20TJ.%20Two%20sides%20of%20the%20same%20coin%3A%20EGFR%20ex-on%2019%20deletions%20and%20insertions%20in%20lung%20cancer.[published online ahead of print Feb 8,2012].
[10] Pirker R,Pereira JR,yon Pawel J,et al.EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer:analysis of data from the phase 3 FLEX study.Lancet Oncol,2012,13(1):33-42.
[11] Kim HR.Shim HS,Chung JH,et al.Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement.Cancer, 2012.118(3):729-739.
[12] Hnn CB,Ma JT.Li F, et a1.EGFR and KRASmutations and altered o-Met gene copy numbers in primary non-small cell lung cancer and associated stage N2 lymph node-metastasis.Cancer Lett 2012. 314(1):63-72.
[13] Yoshioka H,Yamameto S,Hanaoka H,el a1.In rive therapeutic effect of CDH3/P-cedherin-targeting radioimmunotherapy[J/OL]. Cancer Immanol lmmunother,2012,61[2012-03-15].http://www.nebi.nlm.nih.gov/pubmed?term=Yoshioka%20H%2C%20Yamamoto%20S%2C%20Haunoka%20H%2c%20et%2C%20in%20vivo%20therapeutic%20effect%200f%20CDH3%2HLeedherin-targeting%20redioimmunotherapy.[published online ahead of print Jan 6.2012].
[14] D’Arienzo M,Cieone F,Chiacchiararelli L el a1.Three dimensional patient-specific dosimetty in radioimmunotherapy with 90Y ihritumomab-tiuxetan.Cancer Biother Radiopharm,2012,27(2):124-133[2012-03-15]. http://www.ncbi.nlm.nih.gov/pubmed?term=D’Arien-zo%20M%2C%20Cleone%20F%2C%20Chiacchiarareili%20L%2C%20et%20n1.%20Three-dimemional%20patient-specific%20dosimctry%20in%20redioirnmunothempy%20with%2090Y-ibri-tumomab-tiuxelan.%20.[published online aheed of print Jan27.2014
[15] Khawli LA,Hu P,Epstein AL.Cytokine,ehemokine,and co-stimu-latory fusion proteins for the immunotherapy of solid tumom.Handb Exp Pharmacol.2008.181:291-328.
[16] Yi LK,Ju DW,Chen WP.et a1.131I-chTNT radioimmalmtherapy of 43 patients with advanced lung cancer.Cancer Biother Radiopharm, 2006,21(1):5-14.
[17] Chen sL,Yu LK,Jiang CY.et a1.Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment redioimmunotherapy in patients with advanced lung cancer.Clin Oncol,2005,23(7): 1538-1547.
[18] BoeHnan OC,Koppe MJ,Postema EJ.el a1.Radionuclide therapy of cancer with radiolaheled antibodies.Antieancer Agents Med Chem,2007,7(3):335-343.
[19] McLendnn RE,Akabani G,Friedman HS,et a1.Tumor resection cavity administered iodine-131-labeled antitenasein 81C6 tadioimmunothempy in patients with malignant glioma:neuropathology aspects.Nucl Med Bid,2007,34(4):加5-413.
[20] Street HH,Goris ML Fisher GA,etal.Phase I study of of 131I-chimeric (eh)TNT-l/B monoclonal antibody for the treatment of advanced coloncancer.Cancer Biother Radiophann,2006,2l(3):243-256.
[21] Hdeib A,Slosh AE.Convection-enhanced delivery of 131I-chTNT.1, B mAB for treatment of hish-grade adult glinmas.Expert Opin Biol Ther,201l,11(6):799-806.
[22] Yan Y,Zhang HF.Zhang YD.el a1.Trandection of the human sodium/iodide symperter(NIS)gene with lipesomes and the expression of the NIS pmtein in human lung A549 cancer cells.Chin J CLin Oncol,2008,5(1):30-34.
[23] Guo R,Zhang YF.Liang S,el a1.Sodium butyrate enhances the expression of baeulovims-mediated sodium/iodide symportcr gene in A549 lung adenocareinoma cells.Nucl Med Commun,2010,31(10):916-921,
[24] Niu G,Krager KJ.Graham MM,et a1.Noninvasive radiologicaI imaging of pulmonary gene transfer and expression using the human sodium iodide symporter.Eur J Nucl Med Mol Imaging.2005.32(5):534-540.
[25] Shi Yz,Zhang J,Liu ZL et a1.Adenovims.mediated and tumorspecific transgene expression of the sodium-iodide symporter from the human telomerase reverse transcriptase promoter enhanees killing of lung eancer cell line in vitro.Chin Med J(Engl),2010.123(15):2070-2076.
[26] Kang do Y,Lee HW,Choi PJ,et a1.Sodium/iodide symperter expression in primary lung cancer with glucose transporter l expression.Pathol Int.2009.59(2):73-79.

相似文献/References:

[1]何燕,苏晋,郑晓霞,等.P-糖蛋白抑制剂在PET显像中的应用研究[J].国际放射医学核医学杂志,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
 He Yan,Su Jin,ZhengXiaoxia,et al.Developing P-glycoprotein inhibitor marked by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
[2]许飞,刘建军,黄钢,等.PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J].国际放射医学核医学杂志,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
 Xu Fei,Liu Jianjun,Huang Gang,et al.The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
[3]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
 Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[4]陈晓艳,张江虹,邵春林.STAT3与辐射敏感相关性的研究进展[J].国际放射医学核医学杂志,2016,40(3):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
 Chen Xiaoyan,Jianghong,Shao Chunlin.Research progresses of correlation between STAT3 and radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
[5]拓飞,张庆,张京,等.2014年度全国放射性核素γ能谱分析质量控制比对[J].国际放射医学核医学杂志,2015,39(5):401.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 011]
 tuo fei,zhang qing,zhang jing,et al.nationwide intercomparison for radionuclide analyses through γ-spectrometry method in 2014[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):401.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 011]
[6]赵舒怡,储小飞,樊赛军.血清肿瘤标志物与肿瘤放疗疗效评估的研究进展[J].国际放射医学核医学杂志,2015,39(5):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
 zhao shuyi,chu xiaofei,fan saijun..progression of study on serum tumor markers in evaluation of tumor radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
[7]赵徵鑫,翟贺争,张文艺,等.质子重离子治疗肿瘤的进展[J].国际放射医学核医学杂志,2016,40(5):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
 Zhao Zhixin,Zhai Hezheng,Zhang Wenyi,et al.Development of proton heavy ion in tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
[8]任佳忠,李永梅,刘岩,等.99Tcm-MDP骨显像胸部异常放射性摄取的原因分析[J].国际放射医学核医学杂志,2016,40(6):459.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
 Jiazhong,Li Yongmei,Liu Yan,et al.Reasons for the abnormal 99Tcm-MDP uptake in the thoracic tissue on bone scintigraphy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):459.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
[9]马彦云,张辉.磁共振体素内不相干运动扩散加权成像的原理及应用进展[J].国际放射医学核医学杂志,2016,40(6):469.[doi:10.3760/cma.j.issn.1673-4114.2016.06.013]
 Ma Yanyun,Zhang Hui.The basic principle and application progress of intravoxel incoherent motion imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):469.[doi:10.3760/cma.j.issn.1673-4114.2016.06.013]
[10]杨卫东,汪静.肿瘤核素靶向治疗新进展[J].国际放射医学核医学杂志,2015,39(1):19.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]
 Yang Weidong,Wang Jing.Advance progress of radionuclide target tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):19.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]
[11]彭武和,程静,曹庆东.核素肺通气/灌注显像在肺栓塞诊断中的现状及进展[J].国际放射医学核医学杂志,2012,36(2):80.[doi:10.3760/cma.j.issn.1673-4114.2012.02.005]
 PENG Wu-he,CHENG Jing,CAO Qing-dong.Present situation and development of the nuclide lung ventilation/perfusion imaging in diagnosis of lung embolim[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(3):80.[doi:10.3760/cma.j.issn.1673-4114.2012.02.005]
[12]黄帆,高阳,张玉民,等.新型渗透性水凝胶作为载体用于肿瘤的放射性核素植入治疗[J].国际放射医学核医学杂志,2017,41(2):81.[doi:10.3760/cma.j.issn.1673-4114.2017.02.001]
 Huang Fan,Gao Yang,Zhang Yumin,et al.New permeable hydrogel for tumor radiotherapy in situ[J].International Journal of Radiation Medicine and Nuclear Medicine,2017,41(3):81.[doi:10.3760/cma.j.issn.1673-4114.2017.02.001]
[13]高之晔,韩星敏.放射性核素标记的胆碱在PET/CT肿瘤显像中的应用[J].国际放射医学核医学杂志,2018,(3):280.[doi:10.3760/cma.j.issn.1673-4114.2018.03.016]
 Gao Zhiye,Han Xingmin.Application of radionuclide-labeled choline in PET/CT tumor imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(3):280.[doi:10.3760/cma.j.issn.1673-4114.2018.03.016]

备注/Memo

备注/Memo:
收稿日期:2012-03-17。
通讯作者:谭建(Email:tanpost@163.com)
更新日期/Last Update: 1900-01-01