[1]任佳忠,李永梅,刘岩,等.99Tcm-MDP骨显像胸部异常放射性摄取的原因分析[J].国际放射医学核医学杂志,2016,40(6):459-463.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
 Jiazhong,Li Yongmei,Liu Yan,et al.Reasons for the abnormal 99Tcm-MDP uptake in the thoracic tissue on bone scintigraphy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):459-463.[doi:10.3760/cma.j.issn.1673-4114.2016.06.011]
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99Tcm-MDP骨显像胸部异常放射性摄取的原因分析(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第6期
页码:
459-463
栏目:
综述
出版日期:
2016-11-25

文章信息/Info

Title:
Reasons for the abnormal 99Tcm-MDP uptake in the thoracic tissue on bone scintigraphy
作者:
任佳忠12 李永梅23 刘岩12 杨国仁2
1. 250117, 济南大学·山东省医学科学院医学与生命科学学院;
2. 250117 济南, 山东大学附属山东省肿瘤医院核医学科;
3. 272000, 济宁市第一人民医院放射科
Author(s):
Jiazhong12 Li Yongmei23 Liu Yan12 Yang Guoren2
1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250117, China;
2. Department of Nuclear Medicine, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China;
3. Department
关键词:
肿瘤99m锝美罗酸盐胸部异常摄取
Keywords:
NeoplasmsTechnetium Tc 99m medronateThoraxAbnormal uptake
DOI:
10.3760/cma.j.issn.1673-4114.2016.06.011
摘要:
99Tcm-MDP骨显像时除全身正常组织及病变骨组织显影外,骨外组织也常不同程度地摄取显像剂而显影,尤以胸部软组织最为常见。研究胸部骨与骨外组织摄取显像剂显像的不同原因,分析其可能蕴含的病变信息,给临床诊疗提供必要的帮助。笔者就近年来有关这方面国内外的研究进行综述。
Abstract:
When it comes to 99Tcm-MDP bone scintigraphy, normal and abnormal bone tissue can uptake skeletal imaging agent, so does the extraosseous tissue, especially the thorax soft tissue. The understanding of the possible explanations for the abnormal 99Tcm-MDP uptake in the thoracic tissue on bone scintigraphy is of great importance to clinical diagnosis. The relevant reports about this field in recent years are reviewed.

参考文献/References:

[1] 支修益, 石远凯, 于金明.中国原发性肺癌诊疗规范(2015年版)[J].中华肿瘤杂志, 2015, 37(1):67-78. DOI:10.3760/cma.j.issn.0253-3766.2015.01.014.Zhi XY, Shi YK, Yu JM.Standards for the diagnosis and treatment of primary lung cancer(2015 version) in China[J].Chin J Oncol, 2015, 37(1):67-78.
[2] 张芬茹, 许建林, 周建平, 等.肿瘤患者骨外软组织摄取骨显像剂的临床意义[J].中国医学影像技术, 2007, 23(7):1076-1079. DOI:10.3321/j.issn:1003-3289.2007.07.037.Zhang FR, Xu JL, Zhou JP, et al.Clinical significance of nonosseous soft tissue uptake of bone trace in cancer patients[J].Chin J Med Imaging Technol, 2007, 23(7):1076-1079.
[3] Kim SJ, Choi JA, Lee SH, et al.Imaging finding of extrapulmonary metastases of osteosarcoma[J].Clin Imaging, 2004, 28(4):291-300. DOI:10.1016/S0899-7071(03)00206-7.
[4] Andreas KB, Stephan N, Sibylle Z, et al.SPECT/CT[J].J Nucl Med, 2008, 49(3):1305-1319. DOI:10.2967/jnumed.107.050195.
[5] 石洪成.SPECT/CT诊断操作规范与临床应用[M].上海:上海科技出版社, 2015:56-78.Shi HC.Procedure guideline and clinical application of hybrid SPECT/diagnostic CT[M].Shanghai:Shanghai Scientific and Technical Publishers, 2015:56-78.
[6] 谢良骏, 曾凤伟, 张峰, 等.核素全身骨显像鉴别诊断肋脊关节骨转移瘤[J].中国介入影像与治疗学, 2014, 11(3):153-156. DOI:10.13929/j.1672-8475.2014.03.004.Xie LJ, Zeng FW, Zhang F, et al.Radionuclide whole body bone imaging in differential diagnosis of costovertebral joint metastases[J].Chin J Interv Imaging Ther, 2014, 11(3):153-156.
[7] 黄定德, 李前伟, 厉红民, 等.放射性核素骨显像不典型表现248例临床分析[J].重庆医学, 2005, 34(8):1137-1138. DOI:1671-8348(2005)08-1137-02.Huang DD, Li QW, Li HM, et al.Clinical analysis of radionuclide whole bone imaging of untypical lesions in 248 cases[J].Chongqing Med J, 2005, 34(8):1137-1138.
[8] Gunay EC, Erdogan A, Apaydin D.Unusual extraosseous tumoral accumulation of 99mTc-MDP in non-Hodgkin’s lymphoma in two cases[J].Rev Esp Med Nucl, 2011, 30(3):162-164. DOI:10.1016/j.remn.2010.04.012.
[9] 李晶, 张建, 杨小丰, 等.99mTc-MDP骨显像在多发性骨髓瘤与多发性骨转移瘤鉴别诊断中的应用价值[J].新疆医学, 2014, 44(7):52-54.Li J, Zhang J, Yang XF, et al.Value of 99mTc-MDP bone imaging in differential diagnosis of multiple myeloma and multiple bone metastases[J].Xinjiang Med J, 2014, 44(7):52-54.
[10] 张一秋, 石洪成, 顾宇参, 等.SPECT/CT骨显像对肺癌骨转移诊断的增益价值[J].中华核医学杂志, 2011, 31(4):219-222. DOI:10.3760/cma.j.issn.0253-9780.2011.04.002.Zhang YQ, Shi HC, Gu YC, et al.The added diagnostic value of SPECT/CT imaging for bone metastases from lung cancer[J].Chin J Nucl Med, 2011, 31(4):219-222.
[11] 张倩, 修雁, 石洪成, 等.核素骨显像与骨质疏松症的诊断[J].中华骨质疏松与骨矿盐疾病杂志, 2012, 5(4):1674-2591. DOI:10.3969/j.issn.1674-2591.2012.04.013.Zhang Q, Xiu Y, Shi HC, et al.Value of radionuclide bone imaging in diagnosis of osteoporosis[J].Chin J Osteoporosis Bone Miner Res, 2012, 5(4):1674-2591.
[12] 孔西建, 刘玉珂, 李盈盈, 等.瘤源性骨软化症的影像学诊断[J].中国医学影像学杂志, 2014, 22(8):1005-5185. DOI:10.3969/j.issn.1005-5185.2014.08.019.Kong XJ, Liu YK, Li YY, et al.Imaging diagnosis of tumor-induced osteomalacia[J].Chin J Med Imaging, 2014, 22(8):1005-5185.
[13] 程旭, 李永军, 徐兆强, 等.99mTc-MDP全身骨扫描在肾性骨病中的显像特点探讨[J].南京医科大学学报(自然科学版), 2014, 34(9):1260-1263. DOI:10.7655/NYDXBNS20140923.Cheng X, Li YJ, Xu ZQ, et al.To investigate the imaging features of renal osteodystrophy in bone 99mTc-MDP scan[J].J Nanjing Med Univ(Nat Sci), 2014, 34(9):1260-1263.
[14] 张连娜, 杨芳, 冯瑾.甲旁亢与骨软化症的骨显像对比分析[J].中国临床医学影像杂志, 2015, 26(9):663-666. DOI:1008-1062(2015)09-0663-04.Zhang LN, Yang F, Feng J.Comparative analysis of bone imaging features of primary hyperparathyroidism and osteomalacia[J].J China Clin Med Imaging, 2015, 26(9):663-666.
[15] Agrawal A, Purandare N, Sridhar E, et al.Imaging findings in a rare case of Extra-Articular chondrocalcinosis[J].Clin Nucl Med, 2012, 37(2):184-187. DOI:10.1097/RLU.0b013e31823ea13e.
[16] Cerci SS, Suslu H, Cerci C, et al.Different findings in Tc-99m MDP bone scintigraphy of patients with sickle cell disease:report of three cases[J].Ann Nucl Med, 2007, 21(5):311-314. DOI:10.1007/s12149-007-0025-z.
[17] 杨中, 徐海青, 吴边, 等.99mTc-MDP骨显像与X线、CT联合诊断SAPHO综合征[J].热带病与寄生虫学, 2014, 12(4):235-253. DOI:10.3969/j.issn.1672-2302.2014.04.015.Yang Z, Xu HQ, Wu B, et al.Combined diagnosis of SAPHO syndrome by 99mTC-MDP bone imaging, X-ray and CT[J].J Trop Dis Parasitol, 2014, 12(4):235-253.
[18] 髙瞻.核素骨显像在肿瘤临床中的应用[J].东南国防医药, 2009, 11(6):523-526. DOI:1672-271X(2009)06-0523-04.Gao Z.Application of nuclide bone imaging in clinical cancer diagnosis[J].Military Med J Southeast China, 2009, 11(6):523-526.
[19] 王娜, 刘生, 蒋宁一, 等.多骨型骨纤维异常增殖症核素骨显像误诊为Paget病1例[J].医学影像学杂志, 2008, 18(2):1006-9011. DOI:1006-9011(2008)02-0186-01.Wang N, Liu S, Jiang NY, et al.Polyostotic fibrous dysplasia misdiagnosed as Paget disease by radionuclide bone imaging:a case report[J].J Med Imaging, 2008, 18(2):1006-9011.
[20] Nagano S, Yokouchi M, Nagayoshi RA, et al.Paget disease of bone in Japanese patients:a report of three cases[J].J Orthop Surg, 2013, 21(3):375-379.
[21] Shimoyama Y, Kusano M, Shimoda Y, et al.Paget’s disease of bone resembling bone metastasis from gastric cancer[J].Clin J Gastroenterol, 2011, 4(4):207-211. DOI:10.1007/s12328-011-0230-0.
[22] 孙达.放射性核素骨显像[M].浙江:浙江大学出版社, 2000:104.Sun D.Radionuclide bone imaging[M].Zhejiang:Zhejiang University Press, 2000:104.
[23] 谢敬慧, 张延军, 张欣, 等.骨外组织摄取骨显像剂的所见及临床意义探讨(附497例报告)[J].中国临床医学影像杂志, 2006, 17(10):588-591. DOI:10.3969/j.issn.1008-1062.2006.10.016.Xie JH, Zhang YJ, Zhang X, et al.The appearances and evaluation of 99Tcm-MDP accumulation in non-osseous tissue:report of 497 cases[J].J China Clin Med Imaging, 2006, 17(10):588-591.
[24] Eagel BA, Stier S, Wakem C.Non-osseous bone scan abnormlities in multiple myeloma associated with hypercalcemia[J].Clin Nucl Med, 1988, 13(12):869-873.
[25] Marwah A, Kumar R, Dasan B, et al.Soft tissue uptake of Tc-99m-MDP in acute lymphoblastic leukemia[J].Clin Imaging, 2002, 26(3):206-208. DOI:10.1016/S0899-7071(01)00384-9.
[26] Ju HU, Seo KW, Jegal Y, et al.A case of alveolar soft part sarcoma of the pleura[J].J Korean Med Sci, 2013, 28(2):331-335. DOI:10.3346/jkms.2013.28.2.331.
[27] Soundararajan R, Naswa N, Sharma P, et al.SPECT-CT for characterization of extraosseous uptake of 99mTc-methylene diphosphonate on bone scintigraphy[J].Diagn Interv Radiol, 2013, 19(5):405-410. DOI:10.5152/dir.2013.054.
[28] Quoix E, Chenard MP, Orion B, et al.A left pleural effusion with a calcified tumoral mass and left hemithoracic uptake on bone scan[J].Lung Cancer, 2001, 32(2):203-205. DOI:10.1016/S0169-5002(00)00234-8.
[29] James B, Chandler NC, Quarless SA.Extraosseous uptake of Tc-99m MDP along the radiation therapy port for recurrent squamous cell carcinoma of the lung[J].Clin Nucl Med, 2005, 30(8):555-557. DOI:10.1097/01.rlu.0000170042.33387.30.
[30] 马超, 匡安仁, 左书耀, 等.放射性核素骨显像骨外异常放射性浓聚影的原因[J].中华核医学杂志, 2006, 26(5):2095-2848.Ma C, Kuang AR, Zuo SY, et al.Reason of radioactive concentration in bone of radionuclide bone imaging[J].Chin J Nucl Med, 2006, 26(5):2095-2848.
[31] Siegel ME, Walker WJ, Campbell JL.Accumulation of Tc-99m-diphosphonate in malignant pleural effusions:detection an verification[J].J Nucl Med, 1975, 16(10):883-885.
[32] Kawase T, Fujii H, Nakahara TA, et al.Intense accumulation of Tc-99m MDP in pericardial metastasis from breast cancer[J].Clin Nucl Med, 2009, 34(3):173-174. DOI:10.1097/RLU.0b013e31819672b9.
[33] Li L, Kuang A, Sheng S, et al.Tc-99m MDP uptake in retroperitoneal malignant peripheral nerve sheath tumor and its metastases[J].Clin Nucl Med, 2006, 31(1):44-45.
[34] Barai S, Kuamr R, Haloi AK, et al.Bone scan demonstrating metastasis to the breast from an ovarian carcinoma and a review of the literature[J].Clin Nucl Med, 2004, 29(3):167-170.
[35] 金星, 林爱珠, 郑石芳.肿瘤患者核素骨显像骨外软组织浓聚的分析[J].中国临床医学影像杂志, 2000, 11(5):332-334. DOI:10.3969/j.issn.1008-1062.2000.05.011.Jin X, Lin AZ, Zheng SF.Analysis of concentration of soft tissues outside bone on nuclide imaging of cancer patients[J].J China Clin Med Imaging, 2000, 11(5):332-334.
[36] Shen YY, Wu YC, Kao CH, et al.Huge primary soft tissue sarcoma of the breast on bone scan[J].Clin Nucl Med, 2014, 39(1):99-101. DOI:10.1097/RLU.0000000000000246.
[37] Palaniswamy SS, Padma S, Harish V, et al.Hypercalcemia with extraosseous MDP uptake in a bone scan as initial presentation in a case of cutaneous T-cell lymphoma[J].J Cancer Res Ther, 2011, 7(1):72-74. DOI:10.4103/0973-1482.80474.

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备注/Memo

备注/Memo:
收稿日期:2016-07-07。
通讯作者:杨国仁,Email:guorenyang@163.com
更新日期/Last Update: 1900-01-01