[1]杨卫东,汪静.肿瘤核素靶向治疗新进展[J].国际放射医学核医学杂志,2015,39(1):19-24,36.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]
 Yang Weidong,Wang Jing.Advance progress of radionuclide target tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):19-24,36.[doi:10.3760/cma.j.issn.1673-4114.2015.01.006]
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肿瘤核素靶向治疗新进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第1期
页码:
19-24,36
栏目:
出版日期:
2015-01-25

文章信息/Info

Title:
Advance progress of radionuclide target tumor therapy
作者:
杨卫东 汪静
第四军医大学西京医院核医学科, 西安, 710032
Author(s):
Yang Weidong Wang Jing
Department of Nuclear Medicine, Xijing Hospital, the Fourth Military Medical University, Xi’an 710032, China
关键词:
肿瘤抗体单克隆放射性核素治疗放射免疫治疗
Keywords:
TumorAntibodies monoclonalRadionuclidetherapyRadioimmunotherapy
DOI:
10.3760/cma.j.issn.1673-4114.2015.01.006
摘要:
利用靶向分子将放射性核素定向导入肿瘤组织实现核素靶向治疗是肿瘤治疗的重要方法。利用单克隆抗体或小分子肽携带治疗性放射性核素,分别与肿瘤细胞表面表达丰富的抗原或受体特异性结合而开展放射免疫治疗或受体介导的核素治疗是靶向治疗的主要策略。近年来,这两种靶向治疗取得较大进展,部分已进入临床应用。随着靶向分子的不断出现、分子靶向技术的不断完善,肿瘤核素靶向治疗终将成为肿瘤治疗的重要方法。
Abstract:
Radionuclide internal therapy is an important method for tumor treatment. Radioim-unotherapy (RIT)and peptide receptor radionuclide therapy (PPRT)are two major strategies for tumor therapy by targeting antigen or receptor over-expressed in tumor cells with radionuclide labeled monoclonal antibody or peptide separately. RIT and PPRT have been dramatically developed with several agents have been used in clinic and more are underwent clinic or pre-clinic trial. The radionuclide therapy will play more important role in tumor therapy with the more specific target been selected and improvement of the methods.

参考文献/References:

[1] 肿瘤核素靶向治疗的研究进展[J].国际放射医学核医学杂志,2008,32(4):206-208.
[2] Witzig TE,Gordon LI,Cabanillas F,et al.Randomized controlled trial of yttrium-90-labeled britumomab tiuxetan radioimmunothera-py versus rituximab immunotherapy for patients with relapsed or re-fractory low-grade,follicular,or transformed B-cell non-Hodgkin’s lymphoma[J].J Clin Oncol,2002,20(10):2453-2463.
[3] Alcindor T,Witzig TE.Radioimmunotherapy with yttrium-90 ibri-tumomab tiuxetan for patients with relapsed CD20+B-cell non-Hodgkin7 slymphoma[J].Curr Treat Options Oncol,2002,3(4):275-282.
[4] Horning SJ,Younes A,Jain V,et al.Efficacy and safety of tositu-momab and iodine-131 tositumomab (Bexxar) in B-cell lymphoma,progressive after rituximab[J].J Clin Oncol,2005,23(4):712-719.
[5] Kaminski MS,Zelenetz AD,Press OW,et al.Pivotal study of io-dine I 131 tositumomab for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin’s lymphomas[J].J Clin Oncol,2001,19(19):3918-3928.
[6] Chen SL, Yu LK,Jiang CY,et al.Pivotal study of iodine-131-la-beled chimeric tumor necrosis treatment radioimmunotherapy inpatients with advanced lung cancer[J].J Clin Oncol,2005,23(7):1538-1547.
[7] Chen ZN,Mi L, Xu J,et al.Targeting radioimmunotherapy of hepa-tocellular carcinoma with Iodine(I-131)metuximab injection:Clin-ical phase I/Ⅱ trials[J].Int J Radiat Oncol Biol Phys,2006,65(2):435-444.
[8] W uL, YangYF,Ge NJ,et al.Hepatic artery injection of 131I-labelledmetuximab combined with chemoembolization for intermediatehepatocellular carcinoma:a prospective nonrandomized study[J].Eur J Nucl Med Mol Imaging,2012,39(8):1306-1315.
[9] Liersch T,Meller J,Kulle B,et al.Phase Ⅱ trial of carcinoembryon-ic antigen radioimmunotherapy with 131I-labetuzumab after salvage resection of colorectal metastases in the liver:five-year safety and efficacy results[J].J Clin Oncol,2005,23(27):6763-6770.
[10] Han S,Jin G,Wang L,et al.The role of PAM4 in the management of pancreatic cancer:diagnosis,radioimmunodetection,and ra-dioimmunotherapy[J/OL].J Immunol Res,2014,2014:268479[2014-12-10].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003775.
[11] 冯春玲.放射免疫治疗中载体的研究进展[J].国际放射医学核医学杂志,2007,31(2):77-79.
[12] Sahoo SK, Parveen S, Panda JJ.The present and future of nanotech-nology in human health care[J].Nanomedicine,2007,3(1):20-31.
[13] Gobin AM,Lee MH,Halas NJ,et al.Nearinfrared resonant nanoshells for combined opticalimaging and photothermal cancer therapy[J].Nano Lett,2007,7(7):1929-1934.
[14] Hong H,Zhang Y,Sun JT,et al.Molecular imaging and therapy of cancer with radiolabeled nanoparticles[J].Nano Today,2009,4(5):399-413.
[15] Alberti C.From molecular imaging in preclinical/clinical oncology to theranostic applications in targeted tumor therapy[J].Eur Rev Med Pharmacol Sci,2012,16(14):1925-1933.
[16] Baum RP,Kulkarni HR.THERANOSTICS:from molecular imag-ing using Ga-68 labeled tracers and PET/CT to personalized ra-dionuclide therapy-the bad Berka experience[J].Theranostics,2012,2(5):437-447.
[17] Cremonesi M,Ferrari M,Bodei L,et al.Dosimetry in peptide ra-[30] dionuclide receptor therapy:a review[J].J Nucl Med,2006,47(9):1467-1475.
[18] Reubi JC,Schar JC,Waser B,et al.Affinity profiles for human so-matostatin receptor subtypes SST1-SST5 of somatostatin radiotrac-ers selected for scintigraphic and radiotherapeutic use[J].Eur J Nucl Med,2000,27(3):273-282.
[19] Waldherr C,Pless M,Maecke HR,et al.Tumor response and clini-cal benefit in neuroendocrine tumors after 7.4 GBq (90)Y-D0TAT0C[J].J Nucl Med,2002,43(5):610-616.
[20] Kwekkeboom DJ,de Herder WW,Kam BL,et al.Treatment with the radiolabeled somatostatin analog[177Lu-D0TA0,Tyr3] octreo-tate:toxicity,efficacy,and survival[J].J Clin Oncol,2008,26(13):2124-2130.
[21] Imhof A,Brunner P,Marincek N,et al.Response,survival,andlong-term toxicity after therapy with the radiolabeled somatostati-Nanalogue[99Y-DOTAJ-TOC in metastasized neuroendocrine cancers[J].J Clin Oncol,2011,29(17):2416-2423.
[22] Jurcic JG,Larson SM,Sgouros G,et al.Targeted alpha particle im-munotherapy for myeloidleukemia[J].Blood,2002,100(4):1233-1239.
[23] Nilsson S,Franzen L,Parker C,et al.Bone-targeted radium-223 in symptomatic,hormonerefractoryprostate cancer:a randomised,multicentre,placebo-controlled phase Ⅱ study[J].Lancet Oncol,2007,8(7):587-594.
[24] Zalutsky MR,Reardon DA,Akabani G,et al.Clinical experience with alpha-particle emitting 211At:treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6[J].J Nucl Med,2008,49(1):30-38.
[25] Nayak T,Norenberg J,Anderson T,et al.A comparison of high-ver-sus low-linear energy transfer somatostatin receptortargeted ra-dionuclide therapy in vitro[J].Can Biother Radio,2005,20(1):52-57.
[26] Nayak TK,Norenberg JP,Anderson TL,et al.Somatostatin-recep-tor-targeted alpha-emitting Bi-213 is therapeutically more effective than beta-emitting Lu-177 in human pancreatic adenocarcinoma cells[J].Nucl Med Biol,2007,34(2):185-193.
[27] Kratochwil C,Giesel FL,Bruchertseifer F,et al.213Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation:a first-in-hu-man experience[J].Eur J Nucl Med Mol Imaging,2014,41(11):2106-2119.
[28] de Jong M,Breeman WA,Valkema R,et al.Combination radionu-clide therapy using 177Lu-and 90Y-labeled somatostatin analogs[J].J Nucl Med,2005,46(Suppl 1):13S-17S.
[29] Kunikowska J,Królicki L,Hubalewska-Dydejczyk A,et al.Clinicalresults of radionuclide therapy of neuroendocrine tumours with 90Y-DOTATATE and tandem 90Y/177Lu-DOTATATE:which is a bettertherapy option?[J].Eur J Nucl Med Mol Imaging,2011,38(10):1788-1797.
[30] Villard L,Romer A,Marincek N,et al.Cohort study of somato-statin-based radiopeptide therapy with[(90)Y-DOTA]-TOC versus [(90)Y-DOTA]-TOC plus[(177)Lu-DOTA]-TOC in neuroendocrine cancers[J].J Clin Oncol,2012,30(10):1100-1106.
[31] Sawada N,Ishikawa T,Sekiguchi F,et al.X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda)in human cancer xenografts[J].Clin Cancer Res,1999,5(10):2948-2953.
[32] Rich TA,Shepard RC,Mosley ST.Four decades of continuing in-novation with fluorouracil:current and future approaches to fluo-rouracil chemoradiation therapy[J].J Clin Oncol,2004,22(11):2214-2232.
[33] van Essen M,Krenning EP,Kam BL,et al.Report on short-term side effects of treatments with 177Lu-octreotate in combination with capecitabine in seven patients with gastroenteropancreatic neuroen-docrine tumours[J].Eur J Nucl Med Mol Imaging,2008,35(4):743-748.
[34] Claringbold PG,Brayshaw PA,Price R A,et al.Phase Ⅱ study ofradiopeptide 177 Lu-octreotate and capecitabine therapy of progres-sive disseminated neuroendocrine tumours[J].Eur J Nucl Med MolImaging,2011,38(2):302-311.
[35] Nayak TK,Atcher RW,Prossnitz ER,et al.Enhancement of somatostatin-receptor-targeted (177) Lu-[DOTA(0)-Tyr(3)]-oc-treotide therapy by gemcitabine pretreatment-mediated receptor uptake,up-regulation and cell cycle modulation[J].Nucl Med Biol,2008,35(6):673-678.
[36] Kaemmerer D,Prasad V,Daffner W,et al.Neoadjuvant peptide re-ceptor radionuclide therapy for an inoperable neuroendocrine pan-creatic tumor[J].World J Gastroenterol,2009,15(46):5867-5870.
[37] Stoeltzing O,Loss M,Huber E,et al.Staged surgery with neoadju-vant (90) Y-DOTATOC therapy for down-smng synchronous bilob-ular hepatic metastases from a neuroendocrine pancreatic tumor[J].Langenbecks Arch Surg,2010,395(2):185-192.
[38] Breeman WA,Mearadji A,Capello A,et al.Anti-tumor effect and increased survival after treatment with[177Lu-DOTAO,Tyr3] octreo-tate in a rat liver micrometastases model[J].Int J Cancer,2003,104(3):376-379.
[39] Ginj M,Zhang H,Waser B,et al.Radiolabeled somatostatin recep-tor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors[J].Proc Natl Acad Sci USA,2006,103(44):16436-16441.
[40] Cescato R,Waser B,Fani M,et al.Evaluation of 177Lu-DOTA-sst2 antagonist versus 177Lu-DOTA-sst2 agonist binding in human can-cers in vitro[J].J Nucl Med,2011,52(12):1886-1890.
[41] Wild D,Fani M,Behe M,et al.First clinical evidence that imaging with somatostatinreceptor antagonists is feasible[J].J Nucl Med,2011,52(9):1412-1417.
[42] Wild D,Fani M,Fischer R,et al.Comparison of somatostatin re-ceptor agonist and antagonist for peptide receptor radionuclide therapy:a pilot study[J].J Nucl Med,2014,55(8):1248-1252.
[43] Zhu ZH,Miao WB,Li QW,et al.99mTc-3PRGD2 for integrin recep-tor imaging of lung cancer:a multicenter study[J].J Nucl Med,2012,53(5):716-722.

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备注/Memo

备注/Memo:
收稿日期:2014-12-11。
基金项目:国家自然科学基金(81371594)
通讯作者:杨卫东,Email:yangwd1971@163.com
更新日期/Last Update: 1900-01-01