[1]赵徵鑫,翟贺争,张文艺,等.质子重离子治疗肿瘤的进展[J].国际放射医学核医学杂志,2016,40(5):384-388,393.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
 Zhao Zhixin,Zhai Hezheng,Zhang Wenyi,et al.Development of proton heavy ion in tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):384-388,393.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第5期
页码:
384-388,393
栏目:
综述
出版日期:
2016-09-25

文章信息/Info

Title:
Development of proton heavy ion in tumor therapy
作者:
赵徵鑫 翟贺争 张文艺 焦玲
300192 天津, 中国医学科学院北京协和医学院放射医学研究所, 天津市放射医学与分子核医学重点实验室
Author(s):
Zhao Zhixin Zhai Hezheng Zhang Wenyi Jiao Ling
Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China
关键词:
质子重离子放射疗法肿瘤
Keywords:
ProtonsHeavy ionsRadiotherapyNeoplasms
DOI:
10.3760/cma.j.issn.1673-4114.2016.05.010
摘要:
对于恶性肿瘤而言,传统的治疗手段主要包括手术、化疗、常规放疗等。尽管这些治疗手段在肿瘤治疗方面发挥了重要作用,但也存在很大的不足,有的治疗效果不佳,有的存在严重的并发症。为了解决上述治疗手段在肿瘤治疗方面存在的问题,国内外研究者成功研发出新的治疗手段——质子重离子放疗。笔者对此种治疗手段的基本原理和临床应用效果进行详细的介绍,以便为肿瘤科医师和患者在治疗过程中提供更多的信息和决策支持。
Abstract:
For malignant tumor, the traditional treatments mainly include surgery, chemotherapy, conventional radiotherapy, etc. Although these treatments play an important role in tumor therapy, however, there are still significant deficiencies:some clinical treatment ineffective, and some serious complications. In order to solve these problems which caused by the above treatment in tumor therapy, domestic and foreign researchers have successfully developed a new treatment-proton heavy ion radiotherapy. The author makes a detailed introduction to the basic principles and clinical application of this treatment method, and provide more information and support for cancer patients and oncologist.

参考文献/References:

[1] Chen W, Zheng R, Baade PD, et al.Cancer statistics in China, 2015[J].CA Cancer J Clin, 2016, 66(2):115-132.DOI:10.3322/caac.21338.
[2] Siegel RL, Miller KD, Jemal A.Cancer statistics, 2016[J].CA Cancer J Clin, 2016, 66(1):7-30.DOI:10.3322/caac.21332.
[3] Torre LA, Bray F, Siegel RL, et al.Global cancer statistics, 2012[J].CA Cancer J Clin, 2015, 65(2):87-108.DOI:10.3322/caac.21262.
[4] Yock TI, Caruso PA.Risk of second cancers after photon and proton radiotherapy:a review of the data[J].Health Phys, 2012, 103(5):577-585.DOI:10.1097/HP.0b013e3182609ba4.
[5] Hamada N, Imaoka T, Masunaga S, et al.Recent advances in the biology of heavy-ion cancer therapy[J].J Radiat Res, 2010, 51(4):365-383.DOI:10.1269/jrr.09137.
[6] Schipler A, Iliakis G.DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice[J].Nucleic Acids Res, 2013, 41(16):7589-7605.DOI:10.1093/nar/gkt556.郭传玲, 王菊芳, 魏巍, 等.高LET重离子照射人肿瘤细胞的DNA双链断裂及修复研究[J].核技术, 2007, 30(9):750-753.DOI:10.3321/j.issn:0253-3219.2007.09.007.
[7] Guo CL, Wang JF, Wei W, et al.DNA double Strand break and repair of human tumor cells irradiated by high LET heavy ions[J].Nucl Tech, 2007, 30(9):750-753.
[8] Averbeck NB, Topsch J, Scholz MA, et al.Efficient rejoining of DNA double-strand breaks despite increased cell-Killing effectiveness following spread-out bragg peak carbon-ion irradiation[J].Front Oncol, 2016, 6(28):1-8.DOI:10.3389/fonc.2016.00028.
[9] Kanai T, Furusawa Y, Fukutsu K, et al.Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy[J].Radiat Res, 1997, 147(1):78-85.DOI:10.2307/3579446.
[10] Tsujii H, Kamada T.A review of update clinical results of Carbon ion radiotherapy[J].Jpn J Clin Oncol, 2012, 42(8):670-685.DOI:10.1093/jjco/hys104.
[11] Sisterson JM.Clinical use of protons and ion beams from a word-wide perspective[J].Nucl Instrum Meth Biol, 1989, 40(41):1350-1352.DOI:10.1016/0168-583X(89)90654-X.
[12] Ando K, Kase Y.Biological characteristics of carbon-ion therapy[J].Int J Radiat Biol, 2009, 85(9):715-728.DOI:10.1080/09553000903072470.
[13] Ogata T, Teshima T, Kagawa K, et al.Particle irradiation suppresses metastatic potential of cancer cells[J].Cancer Res, 2005, 65(1):113-120.
[14] Cui X, Oonishi K, Tsujii H, et al.Effects of Carbon ion beam on putative colon cancer stem cells and its comparison with x-rays[J].Cancer Res, 2011, 71(10):3676-3687.DOI:10.1158/0008-5472.CAN-10-2926.
[15] Weyrather WK, Ritter S, Scholz M, et al.RBE for carbon track-segment irradiation in cell lines of differing repair capacity[J].Int J Radiat Biol, 1999, 75(11):1357-1364.
[16] 陈万青, 郑荣寿, 张思维, 等.2012年中国恶性肿瘤发病和死亡分析[J].中国肿瘤, 2016, 25(1):1-8.DOI:10.11735/j.issn.1004-0242.2016.01.A001.Chen WQ, Zhen RS, Zhang SW, et al.Report of cancer incidence and mortality in China[J].China Cancer, 2016, 25(1):1-8.
[17] Ferlay J, Shin HR, Bray F, et al.Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008[J].Int J Cancer, 2010, 127(12):2893-2917.DOI:10.1002/ijc.25516.
[18] El-Serag HB.Hepatocellular carcinoma[J].N Engl J Med, 2011, 365(12):1118-1127.DOI:10.1056/NEJMra1001683.
[19] Zeng ZC, Jiang GL, Wang GM, et al.DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line[J].World J Gastroenterol, 2002, 8(5):797-803.DOI:10.3748/wjg.v8.i5.797.
[20] Liang SX, Zhu XD, Xu ZY, et al.Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma:The risk factors and hepatic radiation tolerance[J].Int J Radiat Oncol Biol Phys, 2006, 65(2):426-434.DOI:10.1016/j.ijrobp.2005.12.031.
[21] Kato H, Tsujii H, Miyamoto T, et al.Results of the first prospective study of Carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis[J].Int J Radiat Oncol Biol Phys, 2004, 59(5):1468-1476.DOI:10.1016/j.ijrobp.2004.01.032.
[22] Chiba T, Tokuuye K, Matsuzaki Y, et al.Proton beam therapy for hepatocellular carcinoma:a retrospective review of 162 patients[J].Clin Cancer Res, 2005, 11(10):3799-3805.DOI:10.1158/1078-0432.CCR-04-1350.
[23] 刘锐锋, 张秋宁, 高力英, 等.重离子(12C6+)束治疗肝脏恶性肿瘤的初步临床结果[J].辐射研究与辐射工艺学报, 2014, 32(1):14-21.Liu RF, Zhang QN, Gao LY.A preliminary clinical efficacy of heavy ion(12C6+) beam for hepatic malignance[J].Radiat Res Radiat Process, 2014, 32(1):14-21.
[24] 韩苏军, 张思维, 陈万青, 等.中国前列腺癌发病现状和流行趋势分析[J].临床肿瘤学杂志, 2013, 18(4):330-334.DOI:10.3969/j.issn.1009-0460.2013.04.009.Han SJ, Zhang SW, Chen WQ, et al.Analysis of the status and trends of prostate cancer incidence in China[J].Chin Clin Oncol, 2013, 18(4):330-334.
[25] Tsujii H, Mizoe JE, Kamada T, et al.Overview of clinical experiences on carbon ion radiotherapy at NIRS[J].Radiother Oncol, 2004, 73 Suppl 2:S41-49.
[26] Okada T, Tsuji H, Kamada T, et al.Carbon ion radiotherapy in advanced hypofractionated regimens for prostate cancer:from 20 to 16 fractions[J].Int J Radiat Oncol Biol Phys, 2012, 84(4):968-972.DOI:10.1016/j.ijrobp.2012.01.072.
[27] 王佳宁, 耿左军.颅内肿瘤发病规律分析[J].河北医药, 2016, 38(4):505-508.DOI:10.3969/j.issn.1002-7386.2016.04.007.Wang JN, Geng ZJ.Analysis for pathogenesis characteristics of intracranial tumor[J] Hebei Med J, 2016, 38(4):505-508.
[28] Brada M, Pijls-Johannesma M, De Ruysscher D.Proton therapy in clinical practice:current clinical evidence[J].J Clin Oncol, 2007, 25(8):965-970.DOI:10.1200/JCO.2006.10.0131.
[29] Combs SE, Kessel K, Habermehl DA, et al.Proton and Carbon ion radiotherapy for primary brain tumors and tumors of the skull base[J].Acta Oncol(Madr), 2013, 52(7):1504-1509.DOI:10.3109/0284186X.2013.818255.
[30] Rieken S, Habermehl D, Haberer T, et al.Proton and carbon ion radiotherapy for primary brain tumors delivered with active raster scanning at the Heidelberg Ion Therapy Center(HIT):early treatment results and study concepts[J].Radiat Oncol, 2012, 7(41):1-7.DOI:10.1186/1748-717X-7-41.
[31] Hirasawa N, Tsuji H, Ishikawa H, et al.Risk factors for neovascular glaucoma after carbon ion radiotherapy of choroidal melanoma using dose-volume histogram analysis[J].Int J Radiat Oncol Biol Phys, 2006, 67(2):538-543.DOI:10.1016/j.ijrobp.2006.08.080.
[32] Mizoe JE, Hasegawa A, Jingu K, et al.Results of carbon ion radiotherapy for head and neck cancer[J].Radiother Oncol, 2012, 103(1):32-37.DOI:10.1016/j.radonc.2011.12.013.
[33] Shinoto M, Yamada S, Yasuda S, et al.Phase I trial of preoperative, short-course carbon-ion radiotherapy for patients with resectable pancreatic cancer[J].Cancer, 2013, 119(1):45-51.DOI:10.1002/cncr.27723.

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备注/Memo

备注/Memo:
收稿日期:2016-06-29
基金项目:天津市自然科学基金重点项目(16JCZDJC36100);中国医学科学院中央级公益性科研院所基本科研业务费项目(2016ZX310077)
通讯作者:焦玲,Email:jiaoling@irm-cams.ac
更新日期/Last Update: 1900-01-01