[1]马乐,张万春,李晓敏.乳腺癌前哨淋巴结核素显像新进展[J].国际放射医学核医学杂志,2016,40(2):145-148,158.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
　Ma Le,Zhang Wanchun,Li Xiaomin.Evolution of radionuclide imaging of sentinel node lymphscintigraphy in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):145-148,158.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
点击复制

乳腺癌前哨淋巴结核素显像新进展(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第2期
页码:
145-148,158
栏目:
出版日期:
2016-03-25

文章信息/Info

Title:
Evolution of radionuclide imaging of sentinel node lymphscintigraphy in breast cancer
作者:
马乐1;  张万春2;  李晓敏2
1. 030001 太原, 山西医科大学医学影像学系;
2. 030032 太原, 山西大医院核医学科
Author(s):
Ma Le1;  Zhang Wanchun2;  Li Xiaomin2
1. Department of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China;
2. Department of Nuclear Medicine, Shanxi DaYi Hospital, Taiyuan 030032, China
关键词:
乳腺肿瘤; 放射性核素显像; 前哨淋巴结
Keywords:
Breast neoplasma; Radionuclide imaging; Sentinel lymph node
DOI:
10.3760/cma.j.issn.1673-4114.2016.02.012
摘要:
乳腺癌是全球女性发病率最高的恶性肿瘤,为保证患者的生存率、减少术后并发症,20世纪90年代用"腋窝前哨淋巴结活检术取代腋窝淋巴结清扫"的观点被提出并逐渐发展成为乳腺癌患者保乳术的常规方法。除腋窝前哨淋巴结外,内乳前哨淋巴结的重要性同样不容忽视,但是否将其作为前哨淋巴结活检的对象仍存在争议。面对目前形势,核医学工作者做了大量研究,在保证腋窝前哨淋巴结高显示率的同时尽可能提高内乳前哨淋巴结的显示率。笔者对近十年来国内外研究者在乳腺癌前哨淋巴结核素显像中的核素示踪剂、注射技术、显像仪器等方面的最新进展进行综述。
Abstract:
Breast cancer is the most common cancer that affects women worldwide. Axillary sentinel lymph node biopsy was introduced in the 1900s and has become a routine in breast-conserving surgery to ensure survival of patients and reduce complications related to the disease. The importance of the internal mammary sentinel lymph node, in addition to the axillary sentinel lymph node, cannot be ignored. A controversial issue is whether to accept the internal mammary sentinel lymph node as object of sentinel node biopsy. Nuclear medicine researchers have extensively investigated the response of sentinel node lymphoscintigraphy to clinical requirements, thereby improving the detection rate of both axillary and internal mammary sentinel lymph nodes. This review presents the evolution of sentinel node lymphoscintigraphy in terms of nuclide tracer, injection technology, and imaging devices over an almost 10-year period locally and internationally.

参考文献/References:

[1] National Comprehensive Cancer Network:NCCN Breast Cancer Clinical Practice Guidelines in Oncology(Version 1. 2012)[EB/OL]. http://www.nccn.org/professionals/physician_gls/pdf/breast.pdf.
[2] Wilhelm AJ, Mijnhout GS, Franssen EJ. Radiopharmaceuticals in sentinel lymph-node detection-an overview[J]. Eur J Nucl Med, 1999, 26(4 Suppl):S36-42.
[3] Michenfelder MM, Bartlett LJ, Mahoney DW, et al. Particle-size and radiochemical purity evaluations of filtered 99mTc-sulfur colloid prepared with different heating times[J]. J Nucl Med Technol, 2014, 42(4):283-288. DOI:10. 2967/jnmt.114.145391.
[4] 李蕾, 张秀丽, 霍宗伟, 等. 99Tcm-硫胶体不同制备条件及注射部位对乳腺癌前哨淋巴结检出的影响[J]. 中华核医学与分子影像杂志, 2014, 34(4):296-300. DOI:10. 3760/cma. j.issn.2095-2848. 2014.04.007.Lei L, Zhang XL, Huo ZW, et al. Effects of different preparation methods and injection sites of 99Tcm-sulfur colloid on sentinel lymph node detection in breast cancer[J]. Chin J Nucl Med Mol Imaging, 2014, 34(4):296-300.
[5] 李囡, 林保和, 欧阳涛, 等. 99mTc-美罗华用于原发性乳腺癌前哨淋巴结活检[J]. 中国医学影像技术, 2009, 25(4):681-684. DOI:10. 3321/j.issn:1003-3289.2009.04.047.Li N, Lin BH, Ouyang T, et al. Sentinel lymph node biopsy with a novel sentinel lymphoscintigraphy agent 99mTc-Rituximab for breast cancer[J]. Chin J Med Imaging Technol, 2009, 25(4):681-684.
[6] Kameswaran M, Subramanian S, Pandey U, et al. Preliminary evaluation of the potential of 99mTc carbonyl-DTPA-Rituximab as a tracer for sentinel lymph node detection[J]. Appl Radiat Isot, 2016, 107:195-198. DOI:10.1016/j. apradiso. 2015. 10. 025.
[7] 李艳, 李囡, 翟士桢, 等. 特异性前哨淋巴结显像剂99Tcm-rituximab药盒的制备及生物评价[J]. 同位素, 2011, 24 suppl:S85-89.Li Y, Li N, Zhai SZ, et al. Preparation and evaluation of a freeze-dried Kit of 99Tcm-rituximab for sentinel lymph node imaging[J]. J Isot, 2011, 24 suppl:S85-89.
[8] 杨春慧, 李洪玉, 梁积新, 等. 99Tcm标记右旋糖苷衍生物的制备及其生物分布[J]. 同位素, 2012, 25(3):149-154.Yang CH, Li HY, Liang JX, et al. Preparation and biodistribution study of 99Tcm labelled dextran conjugates[J]. J Isot, 2012, 25(3):149-154.
[9] Morais M, Campello MP, Xavier C, et al. Radiolabeled mannosylated dextran derivatives bearing an NIR-fluorophore for sentinel lymph node imaging[J]. Bioconjug Chem, 2014, 25(11):1963-1970. DOI:10.1021/bc500336a.
[10] Surasi DS, O’Malley J, Bhambhvani P. 99mTc-Tilmanocept:A Novel Molecular Agent for Lymphatic Mapping and Sentinel Lymph Node Localization[J]. J Nucl Med Technol, 2015, 43(2):87-91. DOI:10. 2967/jnmt. 115. 155960.
[11] Van Den Berg NS, Buckle T, Kleinjan GI, et al. Hybrid tracers for sentinel node biopsy[J]. Q J Nucl Med Mol Imaging, 2014, 58(2):193-206.
[12] Deininger RA, Lee JY. Comment on "An ATP-based method for monitoring the microbiological drinking water quality in a distribution network" by E. Delahaye et al., 2003. Water Res. 37, 3689-3696[J]. Water Res, 2005, 39(12):2778-2779. DOI:10.1016/j. watres. 2005. 04. 030.
[13] Sappey MPC. Anatomie, Physiologie, Pathologie des vaisseaux Lymphatiques consideres chez L’homme at les Vertebres[M]. Paris:A. Delahaye and E. Lecrosnier, 1874.
[14] Tanis PJ, Nieweg OE, Valdes Olmos RA, et al. Anatomy and physiology of lymphatic drainage of the breast from the perspective of sentinel node biopsy[J]. J Am Coll Surg, 2001, 192(3):399-409. DOI:10.1016/S1072-7515(00)00776-6
[15] Suami H, Pan WR, Mann GB, et al. The lymphatic anatomy of the breast and its implications for sentinel lymph node biopsy:a human cadaver study[J]. Ann Surg Oncol, 2008, 15(3):863-871. DOI:10.1245/s10434-007-9709-9.
[16] Mudun A, Sanli Y, Ozmen V, et al. Comparison of different injection sites of radionuclide for sentinel lymph node detection in breast cancer:single institution experience[J]. Clin Nucl Med, 2008, 33(4):262-267. DOI:10.1097/RLU.0b013e3181662fc7.
[17] 邱鹏飞, 刘雁冰, 赵荣荣, 等. 乳腺癌内乳区前哨淋巴结显像新技术[J]. 中华肿瘤杂志, 2013, 35(11):858-862. DOI:10. 3760/cma. j. issn. 0253-3766. 2013. 11. 013. Qiu PF, Liu YB, Zhao RR, et al. A novel technique for scintigraphic visualization of internal mammary sentinel lymph nodes in breast cancer patients[J]. Chin J Oncol, 2013, 35(11):858-862.
[18] Sadeghi R, Asadi M, Treglia G, et al. Axillary concordance between superficial and deep sentinel node mapping material injections in breast cancer patients:systematic review and meta-analysis of the literature[J]. Breast Cancer Res Treat, 2014, 144(2):213-222. DOI:10. 1007/s10549-014-2866-1.
[19] 贺青卿, 姜军, 杨新华, 等. 乳腺癌淋巴引流途径的临床研究[J]. 中华乳腺病杂志:电子版, 2008, 2(2):140-148. DOI:10. 3969/j. issn. 1674-0807. 2008. 02. 004. He QQ, Jiang J, Yang XH, et al. Clinical study on lymphatic drainage patterns of breast cancer[J]. Chin J Breast Dis(Electronic Version), 2008, 2(2):140-148.
[20] Madsen E, Gobardhan P, Bongers V, et al. The impact on post-surgical treatment of sentinel lymph node biopsy of internal mammary lymph nodes in patients with breast cancer[J]. Ann Surg Oncol, 2007, 14(4):1486-1492. DOI:10. 1245/s10434-006-9230-6.
[21] Sun X, Liu JJ, Wang YS, et al. Roles of preoperative lymphoscintigraphy for sentinel lymph node biopsy in breast cancer patients[J]. Jpn J Clin Oncol, 2010, 40(8):722-725. DOI:10. 1093/jjco/hyq052.
[22] Giammarile F, Alazraki N, Aarsvold JN, et al. The EANM and SNMMI practice guideline for lymphoscintigraphy and sentinel node localization in breast cancer[J]. Eur J Nucl Med Mol Imaging, 2013, 40(12):1932-1947. DOI:10. 1007/s00259-013-2544-2.

相似文献/References:

[1]杨雷,袁卫红,王家平,等.99Tcm-MIBI显像与钼靶X线对乳腺癌诊断的比较研究[J].国际放射医学核医学杂志,2016,40(2):111.[doi:10.3760/cma.j.issn.1673-4114.2016.02.005]
　Yang Lei,Yuan Weihong,Wang Jiaping,et al.Diagnostic value of technetium 99Tcm sestamibi and X-ray mammography in breast cancer: a comparison study[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):111.[doi:10.3760/cma.j.issn.1673-4114.2016.02.005]
[2]邢宇,赵新明.放射性核素标记HER2亲和体分子探针精准诊疗的研究进展[J].国际放射医学核医学杂志,2016,40(2):139.[doi:10.3760/cma.j.issn.1673-4114.2016.02.011]
　Xing Yu,Zhao Xinming.Advances in radionuclide-labeled HER2 affibody molecular probes for precise diagnosis and treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):139.[doi:10.3760/cma.j.issn.1673-4114.2016.02.011]
[3]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
　Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[4]孙芳芳,张欣.uPAR放射性核素靶向显像研究进展[J].国际放射医学核医学杂志,2016,40(3):230.[doi:10.3760/cma.j.issn.1673-4114.2016.03.013]
　Sun Fangfang,Zhang Xin.Research progress of uPAR-targeted nuclear imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):230.[doi:10.3760/cma.j.issn.1673-4114.2016.03.013]
[5]储小飞,赵舒怡,樊赛军.肿瘤干细胞与辐射抗性的研究进展[J].国际放射医学核医学杂志,2015,39(5):431.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 019]
　chu xiaofei,zhao shuyi,fan saijun..advance progress of cancer stem cells and radioresistance[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):431.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 019]
[6]安淑娴,宋少莉,黄钢.放射性核素标记的凋亡显像剂的研究进展[J].国际放射医学核医学杂志,2015,39(6):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
　An Shuxian,Song Shaoli,Huang Gang.Recent advances in apoptosis imaging using radionuclide-labeled tracers[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
[7]陈伟君,孙达.99Tcm-MIBI显像在乳腺癌新辅助化疗中的应用价值[J].国际放射医学核医学杂志,2015,39(6):487.[doi:10.3760/cma.j.issn.1673-4114.2015.06.011]
　Chen Weijun,Sun Da.Clinical value of 99Tcm-MIBI imaging in neoadjuvant chemotherapy of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):487.[doi:10.3760/cma.j.issn.1673-4114.2015.06.011]
[8]胡鸿,唐刚华,聂大红.乳腺癌分子显像研究进展[J].国际放射医学核医学杂志,2015,39(1):91.[doi:10.3760/cma.j.issn.1673-4114.2015.01.019]
　Hu Hong,Tang Ganghua,Nie Dahong.Progress on molecular imaging of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):91.[doi:10.3760/cma.j.issn.1673-4114.2015.01.019]
[9]黄建敏,解朋,刘晓梅,等.以整合素αvβ3为靶点的肿瘤分子显像及靶向治疗[J].国际放射医学核医学杂志,2015,39(3):256.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
　Huang Jianmin,Xie Peng,Liu Xiaomei,et al.Integrins αvβ3 in molecular imaging and targeted therapy of neoplasms[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):256.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
[10]郭宵峰,刘建中,孙琦婷.肺通气/灌注平面显像与肺灌注SPECT/CT对肺栓塞诊断价值的对比性研究[J].国际放射医学核医学杂志,2015,39(4):277.[doi:10.3760/cma.j.issn.1673-4114.2015.04.001]
　Guo Xiaofeng,Liu Jianzhong,Sun Qiting.Comparative study of pulmonary ventilation/perfusion planar imaging and pulmonary perfusion SPECT combined with low-dose CT in the diagnosis of pulmonary embolism[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):277.[doi:10.3760/cma.j.issn.1673-4114.2015.04.001]
[11]汪秀玲,侯先存,徐凯.核医学显像在乳腺癌诊疗中的作用[J].国际放射医学核医学杂志,2006,30(4):222.
　WANG Xiu-ling,HOU Xian-cun,XU Kai.The effection of nuclear medicine in the diagnosis and treat of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):222.
[12]关晏星.乳腺癌核素分子显像的临床研究进展[J].国际放射医学核医学杂志,2006,30(4):225.
　GUAN Yan-xing.Clinic applicatim and propgress of the nuclide molecular imaging in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):225.
[13]郭睿,晋建华.99mTc-depreotide生长抑素受体显像的临床应用研究[J].国际放射医学核医学杂志,2007,31(3):154.
　GUO Rui,JIN Jian-hua.The clinical application and study of 99mTc-depreotide somatostatin receptor imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):154.

备注/Memo

备注/Memo:
收稿日期:2016-01-04。
基金项目:山西省自然科学基金(2015011089)
通讯作者:张万春,Email:zhang_wanchun@126.com
更新日期/Last Update: 1900-01-01