[1]陈伟君,孙达.99Tcm-MIBI显像在乳腺癌新辅助化疗中的应用价值[J].国际放射医学核医学杂志,2015,39(6):487-492.[doi:10.3760/cma.j.issn.1673-4114.2015.06.011]
 Chen Weijun,Sun Da.Clinical value of 99Tcm-MIBI imaging in neoadjuvant chemotherapy of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(6):487-492.[doi:10.3760/cma.j.issn.1673-4114.2015.06.011]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第6期
页码:
487-492
栏目:
出版日期:
2015-11-25

文章信息/Info

Title:
Clinical value of 99Tcm-MIBI imaging in neoadjuvant chemotherapy of breast cancer
作者:
陈伟君1 孙达2
1. 315020, 宁波大学附属医院医学影像中心;
2. 310009 杭州, 浙江大学医学院附属第二医院核医学科
Author(s):
Chen Weijun1 Sun Da2
Medical Imaging Center, Affiliated Hospital of Ningbo University Medical College, Ningbo 315020, China
关键词:
乳腺肿瘤99m锝甲氧基异丁基异腈多药耐药相关蛋白类P-糖蛋白新辅助化疗疗效评估
Keywords:
Breast neoplasmsTechnetium Tc 99m sestamibiMultidrug resistance-associated proteinsP-glycoproteinNeoadjuvant chemotherapyEvaluating curative effect
DOI:
10.3760/cma.j.issn.1673-4114.2015.06.011
摘要:
目前,新辅助化疗(NAC)已成为局部晚期乳腺癌的标准治疗方法,而肿瘤的多药耐药性(MDR)是乳腺癌NAC失败的主要原因之一。MDR的产生与mdrl编码的P-糖蛋白(P-gp)介导的耐药机制有关。99Tcm-MIBI是一种肿瘤阳性显像剂,也是P-gp 的作用底物,可作为非侵入性的体内显像方法用于评估不同肿瘤中P-gp介导的耐药机制。研究显示,99Tcm-MIBI 早期显像反映MIBI进入肿瘤细胞的多少及速率,并与其恶性程度密切相关,可用于NAC疗效的评估;而延迟显像反映MIBI被排出肿瘤细胞外的量及速度,并与细胞膜P-gp的表达及MDR密切相关,可无创性地检测由P-gp引起的多药耐药,预测NAC的敏感性。
Abstract:
Neoadjuvant chemotherapy(NCT) has become a standard therapeutic method for focal advanced breast carcinoma. The multidrug resistance(MDR) of tumors is one of the main causes of chemotherapy failure in breast cancer. MDR development involves the transmembrane P-glycoprotein(P-gp) encoded by the MDR gene MDR1. 99Tcm-methoxyisobutylisonitrile(MIBI) is a radiotracer for scintigraphy of tumors. MIBI is also a transport substrate for P-gp and has been used in assessing P-gp-mediated MDR in a variety of tumors. The nuclear medicine community in the USA has suggested the use of 99Tcm-MIBI scintigraphy as a noninvasive method in in vivo imaging of MDR. Studies have shown that early imaging of 99Tcm-MIBI reveals the accumulative quantity of MIBI in breast tumors, and correlated with malignant extent of tumor. Thus, early imaging through 99Tcm-MIBI can be conducted to evaluate the curative effect of NCT in breast cancer. Delayed imaging reveals the washout rates of MIBI from breast tumors, which is correlated with P-gp expression and MDR. Thus, delayed 99Tcm-MIBI may provide important information on P-gp-mediated MDR and may predict chemotherapy sensitivity.

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备注/Memo

备注/Memo:
收稿日期:2015-3-27。
通讯作者:孙达,Email:sunda_pet@163.com
更新日期/Last Update: 1900-01-01