[1]黄建敏,解朋,刘晓梅,等.以整合素αvβ3为靶点的肿瘤分子显像及靶向治疗[J].国际放射医学核医学杂志,2015,39(3):256-259.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
　Huang Jianmin,Xie Peng,Liu Xiaomei,et al.Integrins αvβ3 in molecular imaging and targeted therapy of neoplasms[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):256-259.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第3期
页码:
256-259
栏目:
出版日期:
2015-05-25

文章信息/Info

Title:
Integrins αvβ3 in molecular imaging and targeted therapy of neoplasms
作者:
黄建敏;  解朋;  刘晓梅;  潘莉萍;  高建青
河北医科大学第三医院核医学科, 石家庄, 050051
Author(s):
Huang Jianmin;  Xie Peng;  Liu Xiaomei;  Pan Liping;  Gao Jianqing
Department of Nuclear Medicine, the Third Hospital, Hebei Medical University, Shijiazhuang 050051, China
关键词:
新生血管化; 病理性; 整合素αvβ3; 放射性核素显像
Keywords:
Neovascularization;  pathologic; Integrin alphaVbeta3; Radionuclide imaging
DOI:
10.3760/cma.j.issn.1673-4114.2015.03.015
摘要:
整合素αvβ3是由两条多肽链组成的跨膜异二聚体糖蛋白,其高表达于肿瘤新生血管内皮细胞和部分肿瘤细胞表面,而在正常血管和组织表面不表达或低表达,其可通过介导细胞黏附来调控肿瘤血管新生,整合素αvβ3能够与体内外含精氨酸-甘氨酸-天冬氨酸序列的物质发生特异性结合。用不同的放射性核素标记,通过PET/CT、SPECT/CT、PET/MRI显像检测肿瘤整合素αvβ3受体的表达水平,在此研究基础上可将其作为肿瘤新生血管显像和肿瘤早期治疗的靶点。现将国内外关于整合素αvβ3靶向药物的设计、放射性核素的选择及相关药物的研究进展等进行综述。
Abstract:
Integrin αvβ3 are heterodimeric transmembrane glycoproteins,consisting of two noncovalently bound transmembrane subunits.It had a high expression on the tumor but it does not expression on the surface of normal blood vessels or the normal organizations or only had a low level expression.It can regulate tumor angiogenesis by cell adhesion.The integrin αvβ3 can specifically recognize and combine with the peptides which containing tripeptide Arg-Gly-Asp (RGD).These RGD peptides are labeled with appropriate nuclide.The PET/CT,SPECT/CT and PET/MRI multimode imaging can be used to examine the tumor integrin αvβ3 expression level.Thus it can be used as a new target for the tumor angiogenesis imaging and therapy.There is a summary on the design of the integrin αvβ3 agents,the choice of appropriate radionuclides and the research direction of these agents.

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备注/Memo

备注/Memo:
收稿日期:2015-03-21。
基金项目:河北省自然科学基金(项目编号:H2014206286)
通讯作者:黄建敏,Email:jm_huang2003@126.com
更新日期/Last Update: 1900-01-01