[1]付彤,瞿卫,王峰.CDl3/氨基肽酶N在新生血管成像中的应用价值[J].国际放射医学核医学杂志,2011,35(6):321-324.[doi:10.3760,cma.j.issn.1673-4114.2011.06.001]
 FU Tong,Qu Wei,WANG Feng.The application of CDl3/aminopeptidase N in the angiogenesis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(6):321-324.[doi:10.3760,cma.j.issn.1673-4114.2011.06.001]
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CDl3/氨基肽酶N在新生血管成像中的应用价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
35
期数:
2011年第6期
页码:
321-324
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The application of CDl3/aminopeptidase N in the angiogenesis imaging
作者:
付彤 瞿卫 王峰
南京医科大学附属南京第一医院核医学科, 南京 210006
Author(s):
FU Tong Qu Wei WANG Feng
Department of Nuclear Medicine, Nanjing First Hospital Affiliated to Nanjing Medicine University, Nanjing 210006, China
关键词:
新生血管化病理性抗原CDl3寡肽类靶向追踪抗肿瘤药
Keywords:
NeovasculaiizationpathologicAntigensCDl3OligopeptidesTarget homingAnti-neoplastic agents
DOI:
10.3760,cma.j.issn.1673-4114.2011.06.001
摘要:
新生血管的发生在恶性肿瘤发生、发展和转移过程起着关键作用。CDl3是人类白血病分级的重要谱系特异性标志物,在新生血管内皮细胞上特异性高表达,在静止血管内皮细胞上不表达。利用荧光、核素标记或磁性纳米颗粒耦联CDl3单克隆抗体、配体,通过分子成像技术可有效探测新生血管的发生,为研究血管相关疾病的发生、发展提供影像学依据;CDl3的配体——天冬氨酸.甘氨酸一精氨酸与各种抗肿瘤药物构成复合物,然后转运到肿瘤新生血管内皮细胞表面与CDl3结合,释放抗肿瘤药物治疗肿瘤。CDl3在与新生血管相关的各类疾病的认识、诊断、治疗的研究中有着突破性进展和良好的前景。
Abstract:
The development and metasis of malignant tumor depend on neovascularization.CDl3 is a significant marker of cells commit to myeloid lineage to classify leukemia,meanwhile it expresses on the neovascular endothelial cells specifically but expresses barely in vascular endothelial cells.Coupling CDl3 monoclonal antibody or CDl3 ligand to CDl3 in fluorescence,radionuclide or magnetic nanoparticles to achieve molecular imaging to probe angiogenesis and provide imaging evidence of the development of angio-genesis associated disease.Asn-Gly-Arg peptide motif compound with different anticancer drugs targeted deliver to neovascular endothelial cells and release the anticancer drugs to treat the tumor.The research of CDl3 to understand,diagnose and treat the angiogenesis associated diseases has gotten breakthrough and have a promising future.

参考文献/References:

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备注/Memo

备注/Memo:
基于FPGA的多cell腔的场平坦度控制收稿日期:2011-07-12。
通讯作者:王峰(Email:fengwangcn@hotmail.com)
更新日期/Last Update: 1900-01-01