[1]潘秀花,杨占山.促血管生成素的功能及应用进展[J].国际放射医学核医学杂志,2006,30(1):53-55.
 PAN Xiu-hua,YANG Zhan-shan.The progress of the function and application about angiopoietion[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):53-55.
点击复制

促血管生成素的功能及应用进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第1期
页码:
53-55
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The progress of the function and application about angiopoietion
作者:
潘秀花 杨占山
215123 苏州, 苏州大学放射医学与公共卫生学院放射毒理教研室
Author(s):
PAN Xiu-hua YANG Zhan-shan
Department of Radiological Toxicology, Institute of Radiation Medicine and Public Health, Suzhou 215007. China
关键词:
血管生成因子新生血管化病理性伤口愈合放射性皮炎
Keywords:
AngiogenesisNeovascularizationpathologicWound healingRadiodermatitis
分类号:
Q513+.2
摘要:
促血管生成素(Ang)作为血管生成的一种因子,分为Ang-1、Ang-2、Ang-3、Ang-4四类亚型,在血管生成中发挥着重要作用。随着对Ang功能的研究进展发现,它参与了许多与血管生成有关的疾病,因此Ang在与血管生成有关的疾病如血管闭塞性疾病、肿瘤和放射性皮肤溃疡修复中有广泛应用前景。
Abstract:
The angiopoietin (Ang) family is important angiogenesis factor, including four members:Ang-1, Ang-2, Ang-3, Ang-4 It play critical role for blood vessel formation. With the progressing of studying about angiopoietion, it has been found that it take part in many diseasesis about angiogenesis. So it will be used widely in future in a lot of diseases,such as ischemic disease, tumor and wounding healing.

参考文献/References:

1 Korpelainen EL.Endothelial receptor tyrosine kinases active the STAT signaling pathway:mutant Tie-2 causing venous malformations signals a distinct STAT activation response.Oncogene,1999,18(1):1-8.
2 Carlson TR,Feng Y,Maisonpierre PC,et al.Direct cell adhesion to the angiopoietins mediated by integrins.J Biol Chem,2001,276(28):26516-26525.
3 Kim I,Kim HG,So JN,et al.Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3’-kinase/Akt signal transduction pathway.Cire Res,2000,86(1):24-29.
4 Cardone MH,Roy N,Stennicke HR,et al.Regulation of cell death protease caspase-9 by phosphorylation.Science,1998,282(5392):1318-1321.
5 Kim I,Kim HG,Moon SO,et al.Angiopoietin-1 induces endothelial sproutin through the activation of facal adhesion kinase and plasmin secretion.Circ Res,2000,86(9):952-959.
6 Gamble JR,Drew J,Trezise L,et al.Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions.Circ Res,2000,87(7):603-607.
7 Holash J,Maisonpierre PC,Compton D,et al.Vessel cooption,regression,and growth in tumors mediated by angiopoietins and VEGF.Science,1999,284(5422):1994-1998.
8 Chen SL,Zhang BR,Mei J,et al.Induction of angiogenesis in ischemic myocardium by adenovirus mediated angiopoietin-1 gene transfer,an experimental study.ZhongHua Yi Xue Za Zhi,2003,83(8):637-640.
9 Eggert A,Ikegaki N,Kwiatkowski J,et al.High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas.Clin Cancer Res,2000,6(5):1900-1908.
10 Joussen AM,Poulaki V,Tsujikawa A,et al.Suppression of diabetic retiopaty with angiopoietin-1.Am J Pathol,2002,160(5):1683-1693.

相似文献/References:

[1]黄建敏,解朋,刘晓梅,等.以整合素αvβ3为靶点的肿瘤分子显像及靶向治疗[J].国际放射医学核医学杂志,2015,39(3):256.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
 Huang Jianmin,Xie Peng,Liu Xiaomei,et al.Integrins αvβ3 in molecular imaging and targeted therapy of neoplasms[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):256.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
[2]郝玉美,贺欣,宋娜玲.靶向肿瘤新生血管整合素αvβ3受体显像研究现状及进展[J].国际放射医学核医学杂志,2014,38(3):179.[doi:10.3760/cma.j.issn.1673-4114.2014.03.010]
 Hao Yumei,He Xin,Song Naling.Progress on tumor angiogenesis imaging targeting integrin αvβ3 receptor[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(1):179.[doi:10.3760/cma.j.issn.1673-4114.2014.03.010]
[3]张一秋,石洪成.肝细胞癌肿瘤新生血管影像学评价的研究进展[J].国际放射医学核医学杂志,2013,37(1):60.[doi:10.3760/cma.j.issn.1673-4114.2013.01.015]
 ZHANG Yi-qiu,SHI Hong-cheng.Advances in assessment of imaging examination for tumor neoangiogenesis induced by hepatocellular carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(1):60.[doi:10.3760/cma.j.issn.1673-4114.2013.01.015]
[4]陈敏,魏玲格,刘晓梅.肿瘤血管生成的分子影像学研究进展[J].国际放射医学核医学杂志,2012,36(2):65.[doi:10.3760/cma.j.issn.1673-4114.2012.02.001]
 CHEN Min,WEI Ling-ge,LIU Xiao-mei.Advances of molecular imaging in tumor angiogenesis[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(1):65.[doi:10.3760/cma.j.issn.1673-4114.2012.02.001]
[5]付彤,瞿卫,王峰.CDl3/氨基肽酶N在新生血管成像中的应用价值[J].国际放射医学核医学杂志,2011,35(6):321.[doi:10.3760,cma.j.issn.1673-4114.2011.06.001]
 FU Tong,Qu Wei,WANG Feng.The application of CDl3/aminopeptidase N in the angiogenesis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(1):321.[doi:10.3760,cma.j.issn.1673-4114.2011.06.001]

备注/Memo

备注/Memo:
收稿日期:2005-04-29。
通讯作者:杨占山(E-mail:fd@suda.edu.cn)
更新日期/Last Update: 1900-01-01