[1]由莉,赵永成.γ-H2AX分析及其在监测电离辐射所致DNA双链断裂中的应用前景[J].国际放射医学核医学杂志,2006,30(1):50-52.
 YOU Li,ZHAO Yong-cheng.γ-H2AX assay and its prospect of detecting DNA double-strand breaks caused by ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):50-52.
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γ-H2AX分析及其在监测电离辐射所致DNA双链断裂中的应用前景(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第1期
页码:
50-52
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
γ-H2AX assay and its prospect of detecting DNA double-strand breaks caused by ionizing radiation
作者:
由莉 赵永成
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所生物学研究室
Author(s):
YOU Li ZHAO Yong-cheng
Department of Biology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
关键词:
电离辐射DNA损伤DNA修复γ-H2AX
Keywords:
Ionizing radiationDNA damageDNA repairγ-H2AX
分类号:
Q691.9
摘要:
近几年的研究表明,组蛋白H2AX在DNA损伤修复、细胞周期检查点调控、基因组稳定的维持和肿瘤抑制中起着重要作用,而且在放射生物学中具有应用前景。磷酸化的组蛋白H2AX (y-H2AX)对DNA双链断裂快速敏感的反应使其成为DNA双链损伤的标志。y-H2AX分析也将在监测电离辐射尤其是低剂量电离辐射所致的DNA双链损伤中拥有广阔的应用前景。
Abstract:
Recently, histone H2AX has been proved to play an important role in DNA repair, cell-cycle checkpoints, genomic stability and tumor suppression. The histone variant H2AX is phosphorylated (denoted as γ-H2AX) in response to the induced DNA double-stranded breaks. And γ-H2AX has been shown to have a rapid and sensitive response to DNA double-strand breaks induced by ionizing radiation. Because γ-H2AX is a reliable marker to DNA double-strand breaks, γ-H2AX assay will make great future in detecting DNA double-strand breaks caused by ionizing radiation, especially in low levels of ionizing radiation.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2005-04-24。
通讯作者:由莉(E-mail:youli_9902@163.com)
更新日期/Last Update: 1900-01-01