[1]王平,关华顺,吕玉民.外周血核基因表达评价辐射生物剂量方法研究进展[J].国际放射医学核医学杂志,2014,38(6):416-420,432.[doi:10.3760/cma.j.issn.1673-4114.2014.06.016]
　Wang Ping,Guan Hua-shun,Lyu Yu-min.Advances of nuclear gene expression signatures in peripheral blood for irradiation biodose estimation[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(6):416-420,432.[doi:10.3760/cma.j.issn.1673-4114.2014.06.016]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第6期
页码:
416-420,432
栏目:
出版日期:
2014-11-25

文章信息/Info

Title:
Advances of nuclear gene expression signatures in peripheral blood for irradiation biodose estimation
作者:
王平1;  关华顺2;  吕玉民1
1. 河南省职业病防治研究院毒理研究室, 郑州, 450052;
2. 河南省驻马店市基础教研室生物教研组, 463000
Author(s):
Wang Ping1;  Guan Hua-shun2;  Lyu Yu-min1
Department of Toxicology, Henan Institute of Occupational Medicine, Zhengzhou 450052, China
关键词:
电离辐射; 生物剂量; 基因芯片; 基因表达
Keywords:
Ionizing radiation; Biological dose; Gene chip; Gene Expression
DOI:
10.3760/cma.j.issn.1673-4114.2014.06.016
摘要:
基因芯片技术可以完整地了解辐射引起的细胞或组织差异基因表达变化,已广泛应用于放射生物学的研究。外周血有核细胞,特别是淋巴细胞对辐射非常敏感,全面了解辐射后外周血有核细胞基因表达变化,对于辐射生物剂量分子指标研究及建立剂量评价模型非常重要。该文总结了目前利用基因芯片技术筛选外周血辐射响应基因,并利用筛选基因表达信号建立评价模型等的研究现状。
Abstract:
As gene chip technology helps get a more comprehensive understanding of the differentially expressed genes in cells or tissues induced by ionizing radiation,it has been widely used in the research of radiobiology to screen biomarkers.The peripheral blood nucleated cells are extremely sensitive to ionizing radiation,especially lymphocytes.Therefore,it is important to better understand the gene expression changes of peripheral blood nucleated cells for studying molecular biomarkers of ionizing radiation biodosimetry and building the prediction model to estimate radiation exposures.The paper briefly describes the latest research progress in screening ionizing radiation response genes from peripheral blood by means of gene chip technology as well as building the prediction model using expression changes of screened genes.

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备注/Memo

备注/Memo:
收稿日期:2014-03-21。
基金项目:国家重点临床专科建设项目(2011-17);河南省医学科技攻关项目(201003146,201303202)
通讯作者:吕玉民(Email:lym636160@sina.com)
更新日期/Last Update: 1900-01-01