[1]刘强,姜恩海,李进,等.SCGE作为辐射生物剂量计的可行性研究[J].国际放射医学核医学杂志,2005,29(3):126-129.
　LIU Qiang,JIANG En-hai,LI Jin,et al.Study on the possibility of SCGE as radiation biological dosimeter[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(3):126-129.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第3期
页码:
126-129
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Study on the possibility of SCGE as radiation biological dosimeter
作者:
刘强;  姜恩海;  李进;  唐卫生;  王知权
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所
Author(s):
LIU Qiang;  JIANG En-hai;  LI Jin;  TANG Wei-sheng;  WANG Zhi-quan
Institute of Radiation Medicine, Chinese Academy of Medical Science and Pecking Union Medical College, Tianjin 300192, China
关键词:
单细胞凝胶电泳; 电离辐射; DNA损伤; 生物剂量计
Keywords:
single cell gel electrophoresis; ionization radiation; DNA injury; biological dosimeter
分类号:
Q503
摘要:
单细胞凝胶电泳技术建立于20世纪80年代,用于检测单个细胞的DNA损伤。放射生物学研究表明,该技术可用于检测精子细胞、肿瘤细胞和淋巴细胞等哺乳动物细胞受照后的DNA损伤。近年来,随着科学技术的不断进步,各种有关软件的深层开发,使得这一技术增添了许多新的内涵。尤其在照后早期,较其他传统生物剂量学技术具有明显优势,用于放射生物剂量学研究将有良好前景。
Abstract:
Single cell gel electrophoresis(SCGE), which has founded in 1980s, can detect the DNA injury in single cell. Studies on radiation biology has indicated that we can detect the DNA injury by SCGE in mammal cells such as sperm cell, tumor cell and lymphocyte after radiation. Recently, along with the rapid progress of technology, new software has been exploited, which adds much new meanings to this method. SCGE reveals a great future in study of radiation biological dosimetry and has more ad-vantage than the other traditional methods, particularly at the early stage after radiation.

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备注/Memo

备注/Memo:
收稿日期:2005-01-05。
更新日期/Last Update: 1900-01-01