[1]何子毅,孟庆勇.电离辐射与细胞凋亡[J].国际放射医学核医学杂志,2004,28(2):90-93.
 HE Zi-yi,MENG Qing-yong.Ionizing radiation and apoptosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(2):90-93.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
28
期数:
2004年第2期
页码:
90-93
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Ionizing radiation and apoptosis
作者:
何子毅 孟庆勇
524023 广东湛江, 广东医学院分析中心
Author(s):
HE Zi-yi MENG Qing-yong
Analysis Center of Guangdong Medical College, Zhanjiang 524023, China
关键词:
电离辐射细胞凋亡机制
Keywords:
ionizing radiationapoptosismechanism
分类号:
Q691.3
摘要:
电离辐射诱导细胞凋亡已成为治疗恶性肿瘤的重要方法,细胞凋亡作为一种主动的细胞消亡过程,与电离辐射的诱导关系正逐步完善,细胞膜改变是电离辐射诱导细胞凋亡的主要特征,电离辐射诱导细胞凋亡的程度与辐射剂量、照射方式及传能线密度密切相关,它的机制包括基因调控、信号转导、离子代谢、酶和蛋白因子的参与,共同形成一个复杂的生物学网络。
Abstract:
To induce cell apoptosis with ionizing radiation becomes an important method in treating tumor now. The correlation between cell apoptosis (a kind of active cell death)and the inducing of ionizing radiation becomes more and more specific. The character of cell apoptosis in-duced by ionizing radiation is related with cell membrane’s change. Cell apoptosis is related with radiation dose, radiation way and linear energy transfer (LET). The mechanism of cell apoptosis may include gene control, signal transduction, ion metabolizability, enzyme and protein. All of these make a complicated biological network.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2003-10-12。
基金项目:广东省卫生厅科学基金资助项目(A2002466)
更新日期/Last Update: 1900-01-01