[1]王芹,刘晓秋,刘强,等.DNA双链断裂修复途径中重要的修复蛋白[J].国际放射医学核医学杂志,2013,37(1):34-37.[doi:10.3760/cma.j.issn.1673-4114.2013.01.010]
　WANG Qin,LIU Xiao-qiu,LIU Qiang,et al.Important DNA repair proteins in DNA double-strand break repair pathways[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(1):34-37.[doi:10.3760/cma.j.issn.1673-4114.2013.01.010]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第1期
页码:
34-37
栏目:
综述
出版日期:
2013-01-25

文章信息/Info

Title:
Important DNA repair proteins in DNA double-strand break repair pathways
作者:
王芹;  刘晓秋;  刘强;  李进;  樊飞跃
北京协和医学院中国医学科学院放射医学研究所, 天津市分子核医学重点实验室, 天津, 300192
Author(s):
WANG Qin;  LIU Xiao-qiu;  LIU Qiang;  LI Jin;  FAN Fei-yue
Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China
关键词:
DNA损伤; DNA; 重组; DNA修复; 非同源末端连接; 同源重组
Keywords:
DNA damage; DNA; recombinant; DNA repair; Non-homologous end joining; Homologous recombination
DOI:
10.3760/cma.j.issn.1673-4114.2013.01.010
摘要:
DNA双链断裂修复是DNA损伤最主要的修复途径之一,修复基因可以修复DNA损伤,保持遗传信息的完整性,从而抑制肿瘤的发生。目前已知参与DNA双链断裂损伤修复的机制有两种——非同源性末端连接和同源重组修复机制。该文介绍了参与非同源末端连接和同源重组修复机制的几种重要的修复蛋白。
Abstract:
DNA double-strand break repair pathway is one of DNA damage repair pathways.DNA repair genes can repair DNA damage,maintain the integrity of the genetic information and inhibit the formation of tumors.There are two mechanisms-non-homologous end joining and homologous recombination to repair DNA double-strand break.In this review,an overview of important repair proteins of non-homologous end joining and homologous recombination pathways was introduced.

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备注/Memo

备注/Memo:
收稿日期:2012-06-03。
基金项目:国家自然科学基金(项目编号:30870583);中国医学科学院放射医学研究所学科发展基金(项目编号:所发0822)
通讯作者:樊飞跃,Email:faithyfan@yahoo.com
更新日期/Last Update: 1900-01-01