[1]顾菲,刘晓秋.肿瘤辐射增敏的分子机制[J].国际放射医学核医学杂志,2006,30(5):298-301.
 GU Fei,LIU Xiao-qiu.The molecular mechanism of tumor radiosensitizer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(5):298-301.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第5期
页码:
298-301
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The molecular mechanism of tumor radiosensitizer
作者:
顾菲 刘晓秋
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所生物研究室
Author(s):
GU Fei LIU Xiao-qiu
Department of Biology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
关键词:
辐射增敏药细胞低氧DNA损伤基因疗法
Keywords:
Hadiosensitizing agentsCell hypoxiaDNA damageGene therapy
分类号:
Q7
摘要:
关于肿瘤辐射增敏的分子机制研究主要包括:DNA损伤的加重及其修复抑制,改变细胞氧合状态,控制细胞周期,转入凋亡相关基因,导入反义物等。不同的辐射增敏剂可通过不同的分子机制提高肿瘤辐射敏感性。分子机制研究将为开发出更高效的辐射增敏剂提供理论依据。
Abstract:
The study of molecular mechanism of tumor radiosensitizer at home and abroad includes:DNA damage and its repair inhibition, change the oxygen content in tumor cells, control cell cycle, induct cell apoptosis correlative gene and so on. Different radiosensitizing agents play its effort in different ways. The study of molecule mechanism will provide academic basis for discovering new radiosensitizing agents which with higher sensitizing effort.

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备注/Memo

备注/Memo:
收稿日期:2006-05-29。
通讯作者:顾菲,E-mail:feigu8@hotmail.com
更新日期/Last Update: 1900-01-01