[1]秦阳华,韩玲.脆性组氨酸三联体基因研究进展[J].国际放射医学核医学杂志,2006,30(1):47-49.
 QIN Yang-hua,HAN Ling.Fragile histidine triad gene and tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):47-49.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第1期
页码:
47-49
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
Fragile histidine triad gene and tumor
作者:
秦阳华 韩玲
200433 上海, 第二军医大学海医系放射医学教研室
Author(s):
QIN Yang-hua HAN Ling
Department of Radiation Medicine, Navy Medicine Faculty, the Second Military Medicial University, Shanghai 200433, China
关键词:
基因脆性组氨酸三联体基因肿瘤抑制辐射效应
Keywords:
Genefragile histidine triadGenetumor suppressorRadiation effects
分类号:
Q344+.13
摘要:
恶性转化是复杂的、渐变的过程,涉及许多遗传改变,包括抑癌基因失活、癌基因激活和其他调节基因功能改变。脆性组氨酸三联体(FHIT)基因是一个新发现的抑癌基因,过去近10年的研究表明其和许多肿瘤有密切的关系。本文综述了近几年分子生物学有关FHIT基因研究的最新进展,并侧重描述了其和辐射致癌的关系。
Abstract:
Malignant transformation is a complex multistep process involving numerous genetic changes, which include loss of tumor suppressor gene function, oncogene activation and alteration of modifier genes. During the past decade, evidence has accumulated in support that FHIT, as a new tumor suppressor gene, plays a roll in many tumors. In this review, described the recent findings in the molecular biology of FHIT, with particular focus on its relationship with radiation carcinogenesis.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2005-06-05。
通讯作者:韩玲(E-mail:linghan8888@yahoo.com.cn)
更新日期/Last Update: 1900-01-01