[1]胡锴勋,艾辉胜.极重度骨髓型与肠型急性放射病的救治进展[J].国际放射医学核医学杂志,2006,30(1):56-59.
 HU Kai-xun,AI Hui-sheng.The progress in treatment of severe hematopoietic and intestinal form of acute radiation syndrome[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):56-59.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第1期
页码:
56-59
栏目:
临床放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
The progress in treatment of severe hematopoietic and intestinal form of acute radiation syndrome
作者:
胡锴勋 艾辉胜
100071 北京, 解放军307医院血液科
Author(s):
HU Kai-xun AI Hui-sheng
Department of Hematology, Affiliated Hospital of Academy of Military Medicine Science, Beijing 100071, China
关键词:
辐射防护剂细胞因子类造血干细胞急性放射病
Keywords:
Radioprotective drugCytokineHematopoietic stem cellAcute radiation syndrome
分类号:
R818.71
摘要:
极重度骨髓型与肠型急性放射病(ARS)一直是医学难以攻克的热点问题。本文从4个方面概括ARS治疗的新进展:①WR-2721作为细胞防护剂的机制和早期应用,可能阻断组织器官的不可逆性放射损伤;②细胞因子治疗放射病的新进展,提出重视造血恢复后患者的免疫重建;③造血干细胞移植的适应证,骨髓间充质干细胞对放射病有重要治疗意义;④放射病的抗感染防护和治疗,临床真菌感染症状出现前,抗真菌用药的适应证。
Abstract:
The acute radiation syndrome (ARS) is hard to be, overcome as the hot medical problem. This article presents the recent advances in the treatment:(1) The amifostin(WR-2721) be mechanism and earlier periods of the cell protection to apply may interrupt organize harm. (2) New directions for therapy are stressed, using cytokines to enhance recovery of hematopoiesis and immune reconstitution. (3) The article presents guidelines for the use of hematopoietic stem cell transplantation and the mesenchymal stem cells (MSCs) have the importance treatment meaning to the ARS. (4) Indications of preemptive therapy of fungal infection in patients are described.

参考文献/References:

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9 Hartong SC,Neelis KJ,Wagemaker G.Co-administration of Flt-3ligand counteracts the actions of thrombopoietin in myelosuppressed rhesus monkeys.Br J Haematol,2003,121(2):359-367.
10 Drygalski A,Xu G,Constantinescu D,et al.The frequency and proliferative potential of megakaryocytic colony-forming cells (MegCFC) in cord blood,cytokine-mobilized peripheral blood and bone marrow,and their correlation with total CFC numbers:implications for the quantitation of Meg-CFC to predict platelet engraftment following cord blood transplantation.Bone Marrow Transplant,2000,25(10):1029-1034.
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备注/Memo

备注/Memo:
收稿日期:2005-06-06。
基金项目:国家"863"计划资助项目(2002AA216081)
通讯作者:胡锴勋(E-mail:hukaixun@tom.com)
更新日期/Last Update: 1900-01-01