[1]孙启和,孙彬,杨永青.冠心病患者血清细胞因子和超敏C-反应蛋白水平测定的临床意义[J].国际放射医学核医学杂志,2010,34(5):291-294.[doi:10.3760/cma.j.issn.1673-4114.2010.05.010]
　SUN Qi-he,SUN Bin,YANG Yong-qing.Clinical application of changes of serum cytokines and hypersensitive C-reactive protein in patients with coronary heart disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(5):291-294.[doi:10.3760/cma.j.issn.1673-4114.2010.05.010]
点击复制

冠心病患者血清细胞因子和超敏C-反应蛋白水平测定的临床意义(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第5期
页码:
291-294
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Clinical application of changes of serum cytokines and hypersensitive C-reactive protein in patients with coronary heart disease
作者:
孙启和1;  孙彬2;  杨永青3
1. 255400, 山东省淄博市齐都医院核医学科;
2. 255400, 山东省淄博市齐都医院胸外科;
3. 215002, 苏州市立医院核医学科
Author(s):
SUN Qi-he1;  SUN Bin2;  YANG Yong-qing3
Department of Nuclear Medicine, Shandong Zibo Qidu Hospital, Zibo 255400, China
关键词:
冠状动脉疾病; 细胞因子类; 肿瘤坏死因子α; C反应蛋白质; 放射免疫测定
Keywords:
Coronary disease; Cytokines; Tumor necrosis factor-alpha; C-reactive protein; Radioimmuno assay
DOI:
10.3760/cma.j.issn.1673-4114.2010.05.010
摘要:
目的 探讨冠心病患者血清中细胞因子和超敏C-反应蛋白(hs-CRP)水平的临床意义。方法 利用放射免疫分析和超敏酶免疫分析法测定124例冠心病患者[其中稳定型心绞痛(SA)41例,不稳定型心绞痛(USA)38例,急性心肌梗死(AMI)45例]血清中自细胞介素1 β(IL-1 β)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)和hs-CRP水平,并与54名正常对照者进行对比研究。结果 124例冠心病患者血清IL-1β、IL-6、IL-8和TNF-α水平较54名正常对照者明显升高(tIL-1β=3.145,tIL-6=3.627,tIL-8=3.054,tTNF-α=3.301,P均<0.01)。其中,41例SA患者血清IL-1β、IL-6、IL-8和TNF-α水平与54名正常对照者比较差异无统计学意义(tIL-1β=1.431,tIL-6=1.587,tIL-8=1.745,tTNF-α=1.461,P均>0.05);38例USA和45例AMI患者血清中IL-1β、IL-6、IL-8和TNF-α水平较54名正常对照者明显升高(USA:tIL-1β=2871,tIL-6=2.748,tIL-8=2.687,tTNF-α=3.145,P均<0.01;AMI:tIL-1β=2.776,tIL-6=2.874,tIL-8=2.689,tINF-α=3.212,P均<0.01);SA、USA和AMI3组患者血清hs-CRP水平较正常对照者升高(tSA=2.617,P<0.05;tUSA=3.018,P<0.01;tAMT=3.189,P<0.01)。冠心病患者血清中IL-1β、IL-6、IL-8、TNF-α和hs-CRP水平随疾病的严重程度而逐渐升高,以AMI患者为最高。结论 血清IL-1β、IL-6、IL-8、TNF-α和hs-CRP水平的测定是诊断SA、USA和AMI疾病的重要指标,并可作为诊断心血管事件发生的参考。
Abstract:
Objective To study clinical application of the changes of serum cytokines and hypersensitive C-reactive protein (hs-CRP) in patients with coronary heart disease. Methods The levels of interleukin-1β(IL-1β), interleukin-6(IL-6), interleukin-8(IL-8), hs-CRP(with high-sensitive enzyme immunoassay)and tumor necrosis factor α(TNF-α)(with radioimmunoassay) in blood serum were determined in 124 patients with coronary heart disease(including 41 patients with stable angina pectoris(SA), 38 patients with unstable angina (USA) and 45 patients with acute myocardial infarction (AMI)) and 54 normal controls, and then comparatively analysed all the data. Results The levels of IL-1β, IL-6, IL-8 and TNF-α in 124 patients with coronary heart disease were significantly higher than those in 54 normal controls (tIL-1β=3.145, tIL-6=3.627, tIL-8=3.054, tTNF-α=3.301, P<0.01). The levels of IL-1β, IL-6, IL-8 and TNF-α in 41 patients with SA were no significantly than those in 54 normal controls (tIL-1β=1.431, tIL-6=1.587, tIL-8=1.745, tTNF-α=1.461, P>0.05). The levels of IL-1β, IL-6, IL-8 and TNF-α in 38 patients with USA and in 45 patients with AMI were significantly higher than those of in 54 normal controls(USA:tIL-1β=2.871, tIL-6=2.748, tIL-8=2.687, tTNF-α=3.145, P<0.01; AMI:tIL-1β=2.776,tIL-6=2.874, tIL-8=2.689, tTNFα=3.212, P<0.01). The level of hs-CRP in SA, USA and AMI groups were higher than thoes in normal controls (tSA=2.617, P<0.05; tUSA=3.018, P<0.01; tAMI=3.189, P<0.01). The levels of IL-1β, IL-6,IL-8, TNF-α and hs-CRP had increasing tendency follow up the severity degree of patients with SA or USA or AMI and the levels of IL-1β, IL-6, IL-8, TNF-α and hs-CRP in patients with AMI were highest in 124 patients with coronary heart disease. Conclusion In the diagnosis of the patients with SA, USA and AMI, the determination of the levels of IL-1β, IL-6, IL-8, TNF-α and hs-CRP in blood serum were important index, and they were references for cardiovascular happened.

参考文献/References:

[1] Simon AD, Yazdani S, Wang W, et al. Circulating levels of ILlbeta, a prothrombotic eytokine, are elevated in unstable angina versus stable angina. J Thromb Thrombolysis, 2000, 9(3):217-222.
[2] Pang G, Ortega M, Zighang R, et al. Autocrine modulation of IL-8 production by sputum neutrophils in chronic bronchial sepsis. Am J Respir Crlt Care Med, 1997, 155(2):726-731.
[3] März W, Wieland H. HMG-CoA reductase inhibition:anti-inflammatory effects beyond lipid lowering?. Herz, 2000, 25(2):117-125.
[4] Aukrust P, Berge RK, Ueland T, et al. Interaction between chemokines and oxidative stress:possible pathogenic role in acute coronary syndromes. J Am Coll Cardiol, 2001, 37(2):485-491.
[5] Saadeddin SM, Habbab MA, Ferns GA. Markers of inflammation and coronary artery disease. Med Sci Monit, 2002, 8(1):RA5-RA12.
[6] Retterstol L, Eikvar L, Berg K. A twin study of C-Reactive Protein compared to other risk factors for coronary heart disease. Atherosclerosis, 2003, 169(2):279-282.
[7] Ridker PM, Rifai N, Rose k et al. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med, 2002, 347(20):1557-1565.
[8] 中华医学会检验分会,卫生部全国临床检验标准委员会临床应用准则专家委员会,卫生部临床检验中心,等.冠状动脉疾病和心力衰竭时心脏标志物临床检测应用建议.中华检验医学杂志,2006,29(9):774-778.

相似文献/References:

[1]周玉祥,蓝博文,黄春榆,等.64排螺旋CT冠状动脉血管成像诊断冠状动脉-肺动脉瘘的应用价值[J].国际放射医学核医学杂志,2016,40(1):26.[doi:10.3760/cma.j.issn.1673-4114.2016.01.006]
　Zhou Yuxiang,Lan Bowen,Huang Chunyu,et al.Clinical value of coronary artery-pulmonary artery fistula revealed by 64-slice spiral CT coronary angiography[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):26.[doi:10.3760/cma.j.issn.1673-4114.2016.01.006]
[2]汪娇,李剑明.18F-FDG PET心肌代谢显像在心肌存活诊断中的应用进展[J].国际放射医学核医学杂志,2015,39(3):252.[doi:10.3760/cma.j.issn.1673-4114.2015.03.014]
　Wang Jiao,Li Jianming.Development of 18F-FDG PET myocardial metabolic imaging in the diagnosis of myocardial survival[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(5):252.[doi:10.3760/cma.j.issn.1673-4114.2015.03.014]
[3]陈越,李剑明.影像融合技术在冠心病中的临床应用进展[J].国际放射医学核医学杂志,2014,38(1):37.[doi:10.3760/cma.j.issn 1673-4114.2014.01.008]
　Chen Yue,Li Jianming.Advances on the clinical applications of the image fusion techniques in coronary heart disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(5):37.[doi:10.3760/cma.j.issn 1673-4114.2014.01.008]
[4]张国建,王雪梅,刘艳阳.PET-CT在冠心病诊断中的临床应用及新进展[J].国际放射医学核医学杂志,2010,34(5):274.[doi:10.3760/cma.j.issn.1673-4114.2010.05.005]
　ZHA NG Guo-jian,WANG Xue-mei,LIU Yan-yang.New progress and clinical application of PET-CT in coronary artery disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(5):274.[doi:10.3760/cma.j.issn.1673-4114.2010.05.005]
[5]邵晓梁,王跃涛.心肌灌注显像与冠状动脉钙化积分对冠心病风险评估的研究现状及相互关系[J].国际放射医学核医学杂志,2011,35(2):99.[doi:10.3760/cma.j.issn.1673-4114.2011.02.008]
　SHA Xiao-liang,WANG Yue-tao.The progress of interrelationship between myocardial perfusion imaging and coronary artery calcium score in cardiac risk assessment[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(5):99.[doi:10.3760/cma.j.issn.1673-4114.2011.02.008]
[6]栾兆生,周雯,唐为国,等.99Tcm标记化合物显像检测冠心病的优化方案探讨[J].国际放射医学核医学杂志,2010,34(1):42.[doi:10.3760/cma.j.issn.1673-4114.2010.01.011]
　LUAN Zhao-sheng,ZHOU Wen,TANG Wei-guo,et al.The optimal program of 99Tcm labeled radionuclide imaging in diagnosing coronary disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(5):42.[doi:10.3760/cma.j.issn.1673-4114.2010.01.011]
[7]杨波,刘长春,张勇,等.99Tcm-MIBI运动负荷-静息心肌灌注显像对冠心病患者经皮腔内冠状动脉血管成形术的疗效评价[J].国际放射医学核医学杂志,2009,33(1):37.[doi:10.3760/cma.j.issn.1673-4114.2009.01.037]
　YANG Bo,LIU Chang-chun,ZHANG Yong,et al.Evaluation of the outcomes of 99Tcm-MIBI stress-rest perfusion imaging in coronary heart disease with percutaneous transluminal coronary angioplasty[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):37.[doi:10.3760/cma.j.issn.1673-4114.2009.01.037]
[8]张晓英,廖端芳.氡及其子体辐射诱发的非癌变效应[J].国际放射医学核医学杂志,2009,33(1):47.[doi:10.3760/cma.j.issn.1673-4114.2009.01.047]
　ZHANG Xiao-ying,LIAO Duan-fang.Radon and its products radiation-induced non-cancerous effect[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):47.[doi:10.3760/cma.j.issn.1673-4114.2009.01.047]
[9]程艳,李思进,李险峰,等.99Tcm-NOET门控心肌灌注SPECT评价冠心病的价值[J].国际放射医学核医学杂志,2009,33(5):257.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.001]
　CHENG Yah,LI Si-jin,LI Xian-feng,et al.Value of 99Tcm-NOET gated myocardial perfusion on patients with coronary heart disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):257.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.001]
[10]程旭,李殿富,徐兆强,等.冠心病影像学检查与辐射剂量[J].国际放射医学核医学杂志,2009,33(5):307.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.017]
　CHENG Xu,LI Dian-fu,XU Zhao-qiang,et al.Radiation dose of cardiac diagnostic imaging in patients with coronary artery disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):307.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.017]

备注/Memo

备注/Memo:
收稿日期:2010-05-10。
通讯作者:孙启和,E-mail:sunqihe007@126.com
更新日期/Last Update: 1900-01-01