[1]栾兆生,周雯,唐为国,等.99Tcm标记化合物显像检测冠心病的优化方案探讨[J].国际放射医学核医学杂志,2010,34(1):42-46.[doi:10.3760/cma.j.issn.1673-4114.2010.01.011]
 LUAN Zhao-sheng,ZHOU Wen,TANG Wei-guo,et al.The optimal program of 99Tcm labeled radionuclide imaging in diagnosing coronary disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(1):42-46.[doi:10.3760/cma.j.issn.1673-4114.2010.01.011]
点击复制

99Tcm标记化合物显像检测冠心病的优化方案探讨(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第1期
页码:
42-46
栏目:
核医学技术与方法
出版日期:
1900-01-01

文章信息/Info

Title:
The optimal program of 99Tcm labeled radionuclide imaging in diagnosing coronary disease
作者:
栾兆生 周雯 唐为国 杨曙光 张杰 刘文清 王永清 李乃义
271000, 山东 泰安, 中国人民解放军第88医院核医学科
Author(s):
LUAN Zhao-sheng ZHOU Wen TANG Wei-guo YANG Shu-guang ZHANG Jie LIU Wen-qing WANG Yong-qing LI Nai-yi
Department of Nuclear Medicine, The 88 th Hospital of Chinese People’s Liberation Army, Tai’an 271000, China
关键词:
放射性核素显像冠状动脉疾病
Keywords:
TechnetiumRadionuclide imagingCoronary disease
DOI:
10.3760/cma.j.issn.1673-4114.2010.01.011
摘要:
目的 探讨99Tcm标记化合物显像检测冠心病的优化方案。方法 选择临床可疑或确诊的冠心病患者4236例,进行99Tcm标记化合物显像8873例次,分析显像结果,提出99Tcm标记化合物显像检测冠心病的优化方案,并与临床资料对照验证。结果 在可疑冠心病诊断、心肌缺血检测、心肌梗死诊断中,该方案准确率高达94.1%。对临床特需的诊断要求如存活心肌检测、"罪犯"血管检测、缺血性心肌病诊断、疗效监测等也有较高的准确率。结论 99Tcm标记化合物显像优化方案可以完成临床对冠心病的大部分诊断要求,克服了核素显像自身的部分缺陷,具有高效、简便、节约的优势,临床指导价值显著。
Abstract:
Objective To investigate the optimal program of 99Tcm labeled radionuclide imaging in diagnosing coronary disease. Methods Four-thousand-two-hundred and thirty-six patients who were suspected or diagnosed with coronary disease were chosen. Eight-thousand-eight-hundred and seventy-three times 99Tcm labeled radionuclide imaging were taken and analyzed. The optimal program of 99Tcm labeled radionuclide imaging were drawn, compared and verified with their clinical information. Results The optimal program had high accuracy in diagnosing the patients of coronary disease, myocardial ischemia, myocardial infarction. It also was exact in special clinical needs of detecting myocardial viability, culprit vessel, ischemic cardiomyopathy and therapy effect. Conclusions The optimal program could satisfy many requirements of diagnosing coronary disease and overcome some defects of radionuclide imaging. So it was one highperforming, convenient and economical program and had significant clinical value.

参考文献/References:

[1] 刘秀杰.核心脏病学研究进展.中华核医学杂志,1999,19(3):129-130.
[2] Hurrell DG,Milavetz J,Hodge DO,et al.Infarct size determination by technetium-99m sestamibi single-photon emission computed tomography predicts survival in patients with chronic coronary artery disease.Am Heart J,2000,140(1):61-66.
[3] Turgut B,Unlu M,Temiz NH,et al.Dobutamine Tc-99m furifosmin SPECT in detection of coronary artery disease:evaluation of same day,rest-stress protocol.Ann Nucl Med,2003,17(7):531-539.
[4] Korosoglou G,Dubart AE,DaSilva KG Jr,et al.Real-time myocardial perfusion imaging for pharmacologic stress testing:added value to single photon emission computed tomography.Am Heart J,2006,151(1):131-138.
[5] Bestetti A,Triulzi A,Di Leo C,et al.Enhanced prognostic stratification of CAD patients with low ejection fraction by stress-rest Tc-99m tetrofosmin gated-SPECT.Acta Cardiol,2004,59(1):17-23.
[6] Canbaz F,Basoglu T,Semirgin SU,et al.Cold infarction areas of varying size in the presence of left ventricular dysfunction:the impact on left ventricular ejection fraction determination by gated SPECT compared to radionuclide ventriculography.Hell J Nucl Med,2005,8(3):149-153.
[7] Ohtaki Y,Chikamori T,Igarashi Y,et al.Differential effects comparing exercise and pharmacologic stress on left ventricular function using gated Tc-99m sestamibi SPECT.Ann Nucl Med,2008,22(3):185-190.
[8] Hayat SA,Dwivedi G,Jacobsen A,et al.Effects of left bundlebranch block on cardiac structure,function,perfusion,and perfusion reserve:implications for myocardial contrast echocardiography versus radionuclide perfusion imaging for the detection of coronary artery disease.Circulation,2008,117(14):1832-1841.
[9] Khalil MM,Elgazzar A,Khalil W,et al.Assessment of left ventricular ejection fraction by four different methods using 99mTc tetrofosmin gated SPECT in patients with small hearts:correlation with gated blood pool.Nucl Med Commun,2005,26(10):885-893.
[10] Cain PA,Ugander M,Palmer J,et al.Quantitative polar representation of left ventricular myocardial perfusion,function and viability using SPECT and cardiac magnetic resonance:initial results.Clin Physiol Funct Imaging,2005,25(4):215-222.
[11] 栾兆生田嘉禾盖鲁粤等.静脉滴注硝酸甘油介入99mTc-MIBI心肌显像评价存活心肌.中华核医学杂志,1998,18(4):201-208.
[12] Matsunari I,Kanayama S,Yoneyama T,et al.Myocardial distribution of 18F-FDG and 99mTc-sestamibi on dual-isotope simultaneous acquisition SPET compared with PET.Eur J Nucl Med Mol Imaging,2002,29(10):1357-1364.
[13] He ZX,Shi RF,Wu YJ,et al.Direct imaging of exercise-induced myocardial ischemia with fluorine-18-labeled deoxyglucose and Tc99m-sestamibi in coronary artery disease.Circulation,2003,108(10):1208-1213.
[14] Kamínek M,Meluzín J,Janousek S,et al.The role of quantitative Tc99m-MIBI gated SPECT/F-18-FDG PET imaging in the monitoring of intracoronary bone marrow cell transplantation.Nucl Med Rev Cent East Eur,2006,9(1):60-64.
[15] Marini C,Giorgetti A,Gimelli A,et al.Extension of myocardial necrosis differently affects MIBG retention in heart failure caused by ischaemic heart disease or by dilated cardiomyopathy.Eur J Nucl Med Mol Imaging,2005,32(6):682-688.
[16] Patel GM,Hauser TH,Parker JA,et al.Quantitative relationship of stress Tc-99m sestamibi lung uptake with resting T1-201 lung uptake and with indices of left ventricular dysfunction and coronary artery disease.J Nucl Cardiol,2004,11(4):408-413.
[17] Prior JO,Monbaron D,Koehli M,et al.Prevalence of symptomatic and silent stress-induced perfusion defects in diabetic patients with suspected coronary artery disease referred for myocardial perfusion scintigraphy.Eur J Nucl Med Mol Imaging,2005,32(1):60-69.
[18] Fleet R,Lespérance F,Arsenault A,et al.Myocardial perfusion study of panic attacks in patients with coronary artery disease.Am J Cardiol,2005,96(8):1064-1068.
[19] Soman P,Lahiri A,Mieres JH,et al.Etiology and pathophysiology of new-onset heart failure:evaluation by myocardial perfusion imaging.J Nucl Cardiol,2009,16(1):82-91.
[20] Shishehbor MH,Lauer MS,Singh IM,et al.In unstable angina or non-ST-segment acute coronary syndrome,should patients with multivessel coronary artery disease undergo multivessel or culpritonly stenting?.J Am Coll Cardiol,2007,49(8):849-854.
[21] Brener SJ,Milford-Beland S,Roe MT,et al.Culprit-only or multivessel revascularization in patients with acute coronary syndromes:an American College of Cardiology National Cardiovascular Database Registry report.Am Heart J,2008,155(1):140-146.
[22] Senior R,Monaghan M,Main ML,et al.Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent:two Phase 3 international trials in comparison with radionuclide perfusion imaging.Eur J Echocardiogr,2009,10(1):26-35.
[23] Elhendy A,Schinkel AF,van Domburg RT,et al.Incidence and predictors of heart failure during long-term follow-up after stress Tc-99m sestamibi tomography in patients with suspected coronary artery disease.J Nucl Cardiol,2004,11(5):527-533.

相似文献/References:

[1]邢宇,赵新明.放射性核素标记HER2亲和体分子探针精准诊疗的研究进展[J].国际放射医学核医学杂志,2016,40(2):139.[doi:10.3760/cma.j.issn.1673-4114.2016.02.011]
 Xing Yu,Zhao Xinming.Advances in radionuclide-labeled HER2 affibody molecular probes for precise diagnosis and treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):139.[doi:10.3760/cma.j.issn.1673-4114.2016.02.011]
[2]马乐,张万春,李晓敏.乳腺癌前哨淋巴结核素显像新进展[J].国际放射医学核医学杂志,2016,40(2):145.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
 Ma Le,Zhang Wanchun,Li Xiaomin.Evolution of radionuclide imaging of sentinel node lymphscintigraphy in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):145.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
[3]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
 Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[4]孙芳芳,张欣.uPAR放射性核素靶向显像研究进展[J].国际放射医学核医学杂志,2016,40(3):230.[doi:10.3760/cma.j.issn.1673-4114.2016.03.013]
 Sun Fangfang,Zhang Xin.Research progress of uPAR-targeted nuclear imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):230.[doi:10.3760/cma.j.issn.1673-4114.2016.03.013]
[5]安淑娴,宋少莉,黄钢.放射性核素标记的凋亡显像剂的研究进展[J].国际放射医学核医学杂志,2015,39(6):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
 An Shuxian,Song Shaoli,Huang Gang.Recent advances in apoptosis imaging using radionuclide-labeled tracers[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
[6]黄建敏,解朋,刘晓梅,等.以整合素αvβ3为靶点的肿瘤分子显像及靶向治疗[J].国际放射医学核医学杂志,2015,39(3):256.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
 Huang Jianmin,Xie Peng,Liu Xiaomei,et al.Integrins αvβ3 in molecular imaging and targeted therapy of neoplasms[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):256.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
[7]郭宵峰,刘建中,孙琦婷.肺通气/灌注平面显像与肺灌注SPECT/CT对肺栓塞诊断价值的对比性研究[J].国际放射医学核医学杂志,2015,39(4):277.[doi:10.3760/cma.j.issn.1673-4114.2015.04.001]
 Guo Xiaofeng,Liu Jianzhong,Sun Qiting.Comparative study of pulmonary ventilation/perfusion planar imaging and pulmonary perfusion SPECT combined with low-dose CT in the diagnosis of pulmonary embolism[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):277.[doi:10.3760/cma.j.issn.1673-4114.2015.04.001]
[8]马春旭,袁卫红.甲状腺结节影像学诊断研究进展[J].国际放射医学核医学杂志,2014,38(1):48.[doi:10.3760/cma.j.issn 1673-4114.2014.01.010]
 Ma Chunxu,Yuan Weihong.Advanced research on imaging diagnosis of thyroid nodule[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(1):48.[doi:10.3760/cma.j.issn 1673-4114.2014.01.010]
[9]吕靖,张一帆.核素分子显像监测胚胎干细胞及诱导性多潜能干细胞移植的研究进展[J].国际放射医学核医学杂志,2014,38(2):106.[doi:10.3760/cma.j.issn.1673-4114.2014.02.009]
 Lyu Jing,Zhang Yifan.Advances in radionuclide imaging of monitoring embryonic stem cells and induced pluripotent stem cells transplantation[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(1):106.[doi:10.3760/cma.j.issn.1673-4114.2014.02.009]
[10]高平,王茜,赵赟赟,等.99Tcm-MDP SPECT/CT显像用于骨肉瘤肺转移的诊断[J].国际放射医学核医学杂志,2014,38(3):148.[doi:10.3760/cma.j.issn.1673-4114.2014.03.002]
 Gao Ping,Wang Qian,Zhao Yunyun,et al.99Tcm-MDP SPECT/CT used in diagnosis of pulmonary metastasis from osteosarcoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(1):148.[doi:10.3760/cma.j.issn.1673-4114.2014.03.002]
[11]徐萍,刘强,李锐.99mTc-明胶的制备和生物学分布研究[J].国际放射医学核医学杂志,2008,32(1):19.
[12]陈坤山.在锝极有限情况下如何充分利用锝进行骨显像[J].国际放射医学核医学杂志,2007,31(4):239.

备注/Memo

备注/Memo:
收稿日期:2009-12-31。
通讯作者:栾兆生,E-mail:luanzs@sina.com
更新日期/Last Update: 1900-01-01