[1]邱李恒,林岩松,李方,等.99Tcm-甲氧基异丁基异腈显像在分化型甲状腺癌随访中的应用[J].国际放射医学核医学杂志,2009,33(5):275-278.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.006]
 QIU Li-heng,LIN Yan-song,LI Fang,et al.The value of 99Tcm-methoxyisobutylisonitrile in follow-up of patients with differentiated thyroid carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):275-278.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.006]
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99Tcm-甲氧基异丁基异腈显像在分化型甲状腺癌随访中的应用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第5期
页码:
275-278
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The value of 99Tcm-methoxyisobutylisonitrile in follow-up of patients with differentiated thyroid carcinoma
作者:
邱李恒 林岩松 李方 蒙增寿
中国医学科学院北京协和医院核医学科, 100730
Author(s):
QIU Li-heng LIN Yan-song LI Fang KANG Zeng-shou
Department of Nuclear Medicine, Peking Union Medical University Hospital, Beijing 100730, China
关键词:
甲状腺肿瘤99m锝-甲氧基异丁基异腈
Keywords:
Thyroid neoplasmsTechnetium Tc 99m sestamibi
DOI:
10.3760/cnla.j.issn.1673-4114.2009.05.006
摘要:
分化型甲状腺癌(DTC)在经过手术、放射性碘治疗、甲状腺激素抑制治疗后,仍需终身随诊。目前DTC的日常随诊方法如常规影像学方法、甲状腺球蛋白测定和131I全身显像仍有其不足之处,临床上常常发现一些患者存在不摄碘的失分化病灶,定位这些失分化的病灶,对确定患者的进一步治疗至关重要。肿瘤阳性显像剂99Tcm-甲氧基异丁基异腈(99Tcm-MIBI),由于其良好的物理和剂量测量方面的特性,价格便宜,国内外对其在DTC随访中的作用做了大量基础及临床研究。本综述主要从原理、显像方法、显像结果分析、优势介绍99Tcm-MIBI显像在DTC随访的应用。
Abstract:
Patient suffered from differentiated thyroid carcinoma(DTC)needs lifetime follow-up even after going through the thyroidectomy,postoperative 131I treatment,thyroid stimulating hormone suppressing therapy.There are disadvantages in DTC routine follow-up,such as conventional radiologieal studies,measurement of serum thyrogiobulin and 131I scintigraphy.It is not rare for us to see patients with dedifferentiated metastases which with no radioiodine uptake,and how to locate these dedifferentiated metastases is of great importance for making further treatment plan.Tumor imaging agent 99Tcm-methoxyisobutylisonitrile(99Tcm-MIBI)is widely used in the clinical and laboratories research of DTC in domestic and overseas,for its excellent physical and dosimetric characteristics and reasonable price.This review relates the application of 99Tcm-MIBI imaging in DTC follow-up,and focuses on its imaging mechanism,clinical methods,imaging interpretation,and the advantages.

参考文献/References:

[1] Cooper DS,Doherty GM,Haugen BR,et al.Management guidelines for patients with thyroid nodules and differentiated thyroid cancer.Thyroid,2006,16(2):109-142.
[2] Salvatore B,Paone G,Klain M,et al.Fluorodeoxyglucose PET/CT in patients with differentiated thyroid cancer and elevated thyroglobulin after total thyroidectomy and (131)I ablation.Q J Nucl Med Mol Imaging,2008,52(1):2-8.
[3] Mausberg R,Crawford B,Uren RF,et al.Minimally invasive radioguided surgery for recurrent thyroid cancer using iodine-123.Clin Nucl Med,2005,30(1):43-44.
[4] Fujie S,Okumura Y,Sato S,et al.Diagnostic capabilities of I-131,Tl-201,and Tc-99m-MIBI scintigraphy for metastatic differentiated thyroid carcinoma after total thyroidectomy.Acta Med Okayama,2005,59(3):99-107.
[5] Noh JY.Predictive value of serum thyroglobulin and diagnostic imaging in post-surgical follow-up of differentiated thyroid cancer.Nippon Riusho,2007,65(11):2069-2072.
[6] Moretti JL,Hauet N,Caglar M,et al.To use MIBI or not to use MIBI? That is the question when assessing tumour cells.Eur J Nucl Med Mol Imaging,2005,32(7):836-842.
[7] Miyamoto S,Kanji K,Misaki T,et al.Evaluation of technetium-99m-MIBI scintigraphy in metastatic differentiated thyroid carcinoma.J Nucl Med,1997,38(3):352-356.
[8] Ronga G,Ventroni G,Montesano T,et al.Sensitivity of[99mTc]methoxyisobutylisonitrile scan in patients with metastatic differentiated thyroid cancer.Q J Nucl Med Mol Imaging,2007,51(4):364-371.
[9] Wong KT,Choi PT,Lee YY,et al.Current role of radionuclide imaging in differentiated thyroid cancer.Cancer Imaging,2008,10(8):159-162.
[10] Zuijdwijk MD,Vogel WV,Corsteus FH,et al.Utility of fluoredeoxyglucose-PET in patients with differentiated thyroid carcinoma.Nucl Med Commun,2008,29(7):636-641.
[11] Fujie S,Okumura Y,Sato S,et al.Diagnostic capabilities of I-131 T1-201 and Tc-99m-MIBI scintigraphy for metastatic differentiated thyroid carcinoma after total thyroidectomy.Acta Med Okayama,2005,59(3):99-107.
[12] Hsu CH,Liu FY,Yen RF,et al.Tc-99m MIBI SPECT in detecting metastatic papillary thyroid carcinoma in patients with elevated human serum thyroglobulin levels hut negative I-131 whole body scan.Endocr Res,2003,29(1):9-15.
[13] Wu HS,Huang WS,Liu YC,et al.Comparison of FDG-PET and technetium-99m MIBI SPECT metastatic cervical lymph nodes in well-differentiated thyroid carcinoma with elevated serum HTG but negative I-131 whole body scan.Anticancer Res,2003,23(5b):4235-4238.
[14] Kücük ON,Gültekin SS,Aras G,et al.Radioiodine whole-body scans,thyroglabulin levels,99Tcm-MIBI scans and computed tomography:results in patients with lung metastases from differentiated thyroid cancer.Nucl Med Commun,2006,27(3):261-266.
[15] Miller DD,Heyl BL,Walsh RA.Lung uptake of technetium-99m hexamibi isonitrile during acute reversible ischemie left vantricular dysfunction in conscious dogs.Circulation,1988,78(suppl):Ⅱ-387.
[16] Rubello D,Piotto A,Pagetta C,et al.(99m)Tc-MIBI radio-guided surgery for recurrent thyroid carcinoma:technical feasibility and procedure,and preliminary clinical results.Eur J Nucl Med Imaging,2002,29(9):1201-1205.
[17] Casara D,Rubello D,Saladini G,et al.Different features of pulmonary metastases in differetiated thyroid cancer:natural history and multivariate statistical analysis of prognostic variables.J Nucl Med,1993,34(10):1626-1631.
[18] 高克加,王建华,叶智卫,等.99mTc-MIBI显像对甲状腺癌疗效的评估价值.上海医学,2002,25(2):89-91.
[19] 王玉君,赵彦辉,崔亚利.99mTc-MIBI全身显像在治疗分化型甲状腺癌转移灶中的应用价值.实用肿瘤学杂志,2008(4):337-338.
[20] 高识,马庆杰,孙辉,等.99Tcm-甲氧基异丁基异腈(MIBI)显像与甲状腺癌远处转移的关系研究.中国老年学杂志,2006,26(9):1196-1197.
[21] 王强,余永利,高秀丽,等.甲状腺癌术后患者颈淋巴结转移影像学比较研究.上海交通大学学报:医学版,2009,29(9):1085-1087.
[22] Rubello D,Salvatori M,Pelizzo MR,et al.Radio-guided surgery of differentiated thyroid cancer using(131)I or 99mTc-sestamibi.Nucl Med Commum 2006,27(1):1-4.
[23] Rubello D,Pelizzo MR,Casara D,et al.Radio-guided surgery for non-131I-avid thyroid cancer.Thyroid,2006,16(11):1105-1111.

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备注/Memo

备注/Memo:
收稿日期:2009-06-04。
通讯作者:林岩松(E-mail:linyansong@csco.org.cn)
更新日期/Last Update: 1900-01-01