[1]李盼丽,宋少莉.碘难治性分化型甲状腺癌靶向药物治疗进展[J].国际放射医学核医学杂志,2016,40(3):202-207.[doi:10.3760/cma.j.issn.1673-4114.2016.03.009]
 Li Panli,Song Shaoli.Radioactive iodine refractory differentiated thyroid cancer targeted therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):202-207.[doi:10.3760/cma.j.issn.1673-4114.2016.03.009]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第3期
页码:
202-207
栏目:
出版日期:
2016-05-25

文章信息/Info

Title:
Radioactive iodine refractory differentiated thyroid cancer targeted therapy
作者:
李盼丽 宋少莉
200127, 上海交通大学医学院附属仁济医院核医学科
Author(s):
Li Panli Song Shaoli
Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
关键词:
甲状腺肿瘤蛋白质酪氨酸激酶分子靶向治疗
Keywords:
Thyroid neoplasmsProtein-tyrosine kinaseMolecular targeted therapy
DOI:
10.3760/cma.j.issn.1673-4114.2016.03.009
摘要:
甲状腺癌是内分泌系统最常见的恶性肿瘤,其中90%为分化型甲状腺癌。外科手术、放射性碘治疗、TSH抑制是目前分化型甲状腺癌治疗的三步曲。虽然目前对分化型甲状腺癌的诊断和治疗手段非常成熟,但是仍有少量患者因病灶出现失分化摄碘能力下降,而无法获益于传统的131I治疗,称为碘难治性分化型甲状腺癌,对于这类患者使用分子靶向药物治疗是甲状腺癌治疗上的进步。甲状腺癌分子病理学的研究,为分子诊断和靶向治疗提供了可靠的理论基础。笔者就目前对于碘难治性分化型甲状腺癌的分子靶向治疗进展进行综述。
Abstract:
Thyroid cancer is the most common endocrine malignancy, and ninety percent is differentiated thyroid cancer. Surgery, radioactive iodine treatment, TSH suppressive therapy is one of the trilogies of differentiated thyroid cancer treatment. Although the diagnosis and treatment of differentiated thyroid cancer is very mature, there are some patients cannot benefit from the radioactive iodine treatment naming RAI-refractory DTC. For these patients showing dedifferentiated and a lower level of iodine uptake now use targeted drugs achieving curative effect. The studies of molecular pathology of thyroid provide a theoretical basis for the diagnosis and treatment of thyroid cancer. This review comprehensively discussing the progress of molecular targeted therapy about refractory thyroid cancer.

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备注/Memo

备注/Memo:
收稿日期:2015-11-20
基金项目:国家自然科学基金(81101073,81471708);上海交通大学医工交叉研究基金(YG2012MS13)
通讯作者:宋少莉,Email:shaoli-song@163.com
更新日期/Last Update: 1900-01-01