[1]关晏星.乳腺癌核素分子显像的临床研究进展[J].国际放射医学核医学杂志,2006,30(4):225-228,231.
 GUAN Yan-xing.Clinic applicatim and propgress of the nuclide molecular imaging in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):225-228,231.
点击复制

乳腺癌核素分子显像的临床研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第4期
页码:
225-228,231
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Clinic applicatim and propgress of the nuclide molecular imaging in breast cancer
作者:
关晏星
330006 南昌, 南昌大学第一附属医院核医学科
Author(s):
GUAN Yan-xing
Department of Nuclear Medicine, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
关键词:
乳腺肿瘤放射性核素显像
Keywords:
Breast neoplasmsRadionuclide imaging
分类号:
R817.4
摘要:
乳腺癌分子显像不断快速发展,得益于新的更特异的显像剂和显像仪器的发展。当前,18F-氟代脱氧葡萄糖(18F-FDG)仍然是最广泛使用的代谢显像剂,但许多针对细胞靶点的更具特异性的示踪剂在发展,如针对DNA复制反映细胞增殖的3’-脱氧.3’-18F-氟代胸苷(18F-FLT)、反映细胞凋亡和雌激素受体状况的99mTc-annexinV和18F-16α-氟雌二醇、针对HER-2/neu受体的基因工程抗体片段等。同机PET-CT的临床应用不断扩大,专门用于乳腺显像的PET及术中探测放射性强度、指导外科医生对转移淋巴结和恶性病灶准确采样的便携式正电子探测器也正投入研究和应用中。
Abstract:
Molecular imaging of breast cancer continues to rapidly expand due to improvements in both instrumentation and newer, more specific tracers.18F-fluorodeoxyglucose (18F-FDG) is still the most widely used tumor imaging agent, but a multitude of new PET tracers are under development, many of which are aimed at targeting cellular processes that are more specific than glucose metabolism. These tracers include thymidine analogs such as 18F-fluoro-L-thymidine (FLT) that target DNA replication as a measure of cell proliferation, annexin V derivatives that evaluate apoptosis, estrogen receptor(ER)tracers such as 16α-(18F-fluoroestradiol-17β, FES), and engineered antibody fragments that directly target HER-2/neu receptors. PET-CT inline scanning was applicated more and more widely. Other new scanning devices are also being developed, including small gantry PET scanners designed specifically for breast imaging, and handheld PET probes for direct intraoperative localization of tracer-avid tumor foci.

参考文献/References:

1 Buck AK,Schirmeister H,Mattfeldt T,et al.Biological characterization of breast cancer by means of PET.Eur J Nucl Med Mol Imaging,2004,31(Suppl 1):S80-S87.
2 Wu D,Gambhir SS.Positron emission tomography in diagnosis and management of invasive breast cancer:.Current status and future perspectives.Clin Breast Cancer,2003,4(Suppl 1):S55-S63.
3 王玲,张炽敏.乳腺肿瘤的影像学诊断进展.国外医学·放射医学核医学分册,2005,29(2):93-96.
4 Kumar A.Fluorodeoxyglucose-PET in the management of breast cancer.Radiol Clin North Am,2004,42(6):1113-1122.
5 Andrew Q,Sanjiv S G.FDG-PET and beyond:Molecular breast cancer imaging.J Clin Oncol,2005,23(8):1664-1673.
6 Wang Y,Yu J,Liu J,et al.PET-CT in the diagnosis of both primary breast cancer and axillary lymph node metastasis:initial experience.Int J Radiat Oncol Biol Phys,2003,57(Suppl 1):362-363.
7 Bellon JR,Livingston RB,Eubank WIB.Evaluation of the internal mammary lymph nodes by FDG-PET in locally advanced breast cancer(LABC).Am J Clin Oncol,2004,27(4):407-410.
8 Eubank WB,Mankoff DA,Takasugi J,et al.18fluorodeoxyglucose positron emission tomography to detect mediastinal or internal mammary metastases in breast cancer.J Clin Oncol,2001,19(12):3516-3523.
9 Lin WY,Tsai SC,Cheng KY,et al.Fluroine-18 FDG-PET in detecting local recurrence and distant metastases in breast cancer-Taiwanese experiences.Cancer Invest,2002,20(5-6):725-729.
10 Pecking Ap,Mechelany-Corone C,Bertrand-kermorgant F,et al.Detection of occult disease in breast cancer using fluorodeoxyglucose camera-based positron emission tomogaphy.Clin Breast Cancer,2001,2(3):229-234.
11 Pelosi E,Messa C,Sironi S,et al.Value of integrated PET/CT for lesion localization in cancer patients:A comparative study.Eur J Nucl Med Mol Imaging,2004,31(6):932-939.
12 Uematsu T,Yuen S,Yukisawa S,et al.Comparison of FDG PET and SPECT for detection of bone metastases in breast cancer.Am J Roentgenol,2005,184(4):1266-1273.
13 Krak NC,Hoekstra OS,Lammertsma AA.Measuring response to chemotherapy in locally advanced breast cancer:methodological considerations.Eur J Nucl Med Mol Imaging,2004,31(Suppl 1):S103-S111.
14 Schelling M,Avril N,Nahrig J,et al.Positron emission tomography using[(18)F] fluorodeoxyglucose for monitoring primary chemotherapy in breast cancer.J Clin Oncol,2000,18(18):1689-1695.
15 Mortimer JE,Dehdashti F,Siegel BA,et al.Metabolic flare:indicator of hormone responsiveness in advanced breast cancer.J Clin Oncol,2001,19(11):2797-2803.
16 Smyczek-Gargya B,Fersis N,Dittmann H,et al.PET with [18F]fluorothymidine for imaging of primary breast cancer:A pilot study.Eur J Nucl Med Mol Imaging,2004,31(5):720-724.
17 Pio BS,Park CK,Silverman DH.PET with fluoro-L-thymididne allows early prediction of breast cancer response to chemotherapy.J Nucl Med,2003,44(1):76-77.
18 Takamura Y,Miyoshi Y,Taguchi T,et al.Prediction of chemotherapeutic response by Technetium 99m-MIBI scintigraphy in breast carcinoma patients.Cancer,2001,92(2):232-239.
19 Fuster D,Munoz M,Pavia J,et al.Quantified 99mTc-MIBI scintigraphy for predicting chemotherapy response in breast cancer patients:factors that influence the level of 99mTc-MIBI uptake.Nucl Med Commun,2002,23(1):31-38.
20 Kim R,Osaki A,Hirai T,et al.Utility of technetium-99m methoxyisobutyl isonitrile uptake analysis for prediction of the response to chemotherapy in advanced and relapsed breast cancer.Breast Cancer,2002,9(3):240-247.
21 Aloj L,Zannetti A,Caraco C,et al.Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines.Eur J Nucl Med Mol Imaging,2004,31(4):521-710.
22 Del Vecchio S,Salvatore M.99mTc-MIBI in the evaluation of breast cancer biology.Eur J Nucl Med Mol Imaging,2004,31(Suppl 1):S88-S96.
23 Zhoanglin Liu,Stevenson GD,Barrett HH,et al.Imaging recognition of inhibition of multidrug resistance in human breast cancer xenografts using 99mTc-labeled sestamibi and tetrofosmin.Nucl Med Biol,2005,32(6):573-583.
24 Britz-Cunning ham,SH,James-Adelstein S.Molecular targeting with radionuclides:state of the science.J Nucl Med,2003,44(12):1945-1961.
25 Bennink RJ,van Tienhoven G,Rijks LJ,et al.In vivo prediction of response to antiestrogen treatment in estrogen receptor-positive breast cancer.J Nucl Med,2004,45(1):1-7.
26 Behr TM,Behe M,Angerstein C,et al.Does pretherapeutic immunoscintigraphy allow for diagnostic predictions with respect to the toxicity and therapeutic efficacy of cold immunotherapy with trastuzumab (Herceptin)?.J Nucl Med,2000,41(1):73.
27 吴浩荣,吴锦昌.Baum R. 99mTc标记抗粘蛋白McAb乳腺癌放射免疫显像的临床研究.中华核医学杂志,2000,20(2):75-77.
28 Murakami Y,Takamatsu H,Taki J,et al.18F-labelled annexin V:a PET tracer for apoptosis imaging.Eur J Nucl Med Mol Imaging,2004,31(4):469-474.

相似文献/References:

[1]杨雷,袁卫红,王家平,等.99Tcm-MIBI显像与钼靶X线对乳腺癌诊断的比较研究[J].国际放射医学核医学杂志,2016,40(2):111.[doi:10.3760/cma.j.issn.1673-4114.2016.02.005]
 Yang Lei,Yuan Weihong,Wang Jiaping,et al.Diagnostic value of technetium 99Tcm sestamibi and X-ray mammography in breast cancer: a comparison study[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):111.[doi:10.3760/cma.j.issn.1673-4114.2016.02.005]
[2]邢宇,赵新明.放射性核素标记HER2亲和体分子探针精准诊疗的研究进展[J].国际放射医学核医学杂志,2016,40(2):139.[doi:10.3760/cma.j.issn.1673-4114.2016.02.011]
 Xing Yu,Zhao Xinming.Advances in radionuclide-labeled HER2 affibody molecular probes for precise diagnosis and treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):139.[doi:10.3760/cma.j.issn.1673-4114.2016.02.011]
[3]陈顺军,程兵.肿瘤细胞凋亡核素显像分子探针研究进展[J].国际放射医学核医学杂志,2016,40(2):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
 Chen Shunjun,Cheng Bing.Progress in molecular probes of radionuclide tumor apoptosis imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):149.[doi:10.3760/cma.j.issn.1673-4114.2016.02.013]
[4]孙芳芳,张欣.uPAR放射性核素靶向显像研究进展[J].国际放射医学核医学杂志,2016,40(3):230.[doi:10.3760/cma.j.issn.1673-4114.2016.03.013]
 Sun Fangfang,Zhang Xin.Research progress of uPAR-targeted nuclear imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):230.[doi:10.3760/cma.j.issn.1673-4114.2016.03.013]
[5]储小飞,赵舒怡,樊赛军.肿瘤干细胞与辐射抗性的研究进展[J].国际放射医学核医学杂志,2015,39(5):431.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 019]
 chu xiaofei,zhao shuyi,fan saijun..advance progress of cancer stem cells and radioresistance[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):431.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 019]
[6]安淑娴,宋少莉,黄钢.放射性核素标记的凋亡显像剂的研究进展[J].国际放射医学核医学杂志,2015,39(6):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
 An Shuxian,Song Shaoli,Huang Gang.Recent advances in apoptosis imaging using radionuclide-labeled tracers[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):470.[doi:10.3760/cma.j.issn.1673-4114.2015.06.008]
[7]陈伟君,孙达.99Tcm-MIBI显像在乳腺癌新辅助化疗中的应用价值[J].国际放射医学核医学杂志,2015,39(6):487.[doi:10.3760/cma.j.issn.1673-4114.2015.06.011]
 Chen Weijun,Sun Da.Clinical value of 99Tcm-MIBI imaging in neoadjuvant chemotherapy of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):487.[doi:10.3760/cma.j.issn.1673-4114.2015.06.011]
[8]胡鸿,唐刚华,聂大红.乳腺癌分子显像研究进展[J].国际放射医学核医学杂志,2015,39(1):91.[doi:10.3760/cma.j.issn.1673-4114.2015.01.019]
 Hu Hong,Tang Ganghua,Nie Dahong.Progress on molecular imaging of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):91.[doi:10.3760/cma.j.issn.1673-4114.2015.01.019]
[9]黄建敏,解朋,刘晓梅,等.以整合素αvβ3为靶点的肿瘤分子显像及靶向治疗[J].国际放射医学核医学杂志,2015,39(3):256.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
 Huang Jianmin,Xie Peng,Liu Xiaomei,et al.Integrins αvβ3 in molecular imaging and targeted therapy of neoplasms[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):256.[doi:10.3760/cma.j.issn.1673-4114.2015.03.015]
[10]郭宵峰,刘建中,孙琦婷.肺通气/灌注平面显像与肺灌注SPECT/CT对肺栓塞诊断价值的对比性研究[J].国际放射医学核医学杂志,2015,39(4):277.[doi:10.3760/cma.j.issn.1673-4114.2015.04.001]
 Guo Xiaofeng,Liu Jianzhong,Sun Qiting.Comparative study of pulmonary ventilation/perfusion planar imaging and pulmonary perfusion SPECT combined with low-dose CT in the diagnosis of pulmonary embolism[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):277.[doi:10.3760/cma.j.issn.1673-4114.2015.04.001]
[11]马乐,张万春,李晓敏.乳腺癌前哨淋巴结核素显像新进展[J].国际放射医学核医学杂志,2016,40(2):145.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
 Ma Le,Zhang Wanchun,Li Xiaomin.Evolution of radionuclide imaging of sentinel node lymphscintigraphy in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):145.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
[12]汪秀玲,侯先存,徐凯.核医学显像在乳腺癌诊疗中的作用[J].国际放射医学核医学杂志,2006,30(4):222.
 WANG Xiu-ling,HOU Xian-cun,XU Kai.The effection of nuclear medicine in the diagnosis and treat of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(4):222.
[13]郭睿,晋建华.99mTc-depreotide生长抑素受体显像的临床应用研究[J].国际放射医学核医学杂志,2007,31(3):154.
 GUO Rui,JIN Jian-hua.The clinical application and study of 99mTc-depreotide somatostatin receptor imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(4):154.

备注/Memo

备注/Memo:
收稿日期:2006-02-25。
更新日期/Last Update: 1900-01-01