[1]陈双景,周平坤,王治东.电离辐射损伤相关长链非编码RNA研究进展[J].国际放射医学核医学杂志,2018,(2):161-166.[doi:10.3760/cma.j.issn.1673-4114.2018.02.011]
 Shuangjing,Zhou Pingkun,Wang Zhidong.Research advancement on long non-coding RNAs in ionizing radiation-induced damage[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(2):161-166.[doi:10.3760/cma.j.issn.1673-4114.2018.02.011]
点击复制

电离辐射损伤相关长链非编码RNA研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
期数:
2018年第2期
页码:
161-166
栏目:
综述
出版日期:
2018-05-09

文章信息/Info

Title:
Research advancement on long non-coding RNAs in ionizing radiation-induced damage
作者:
陈双景 周平坤 王治东
100850 北京, 军事科学院军事医学研究院辐射医学研究所放射生物学研究室
Author(s):
Shuangjing Zhou Pingkun Wang Zhidong
Department of Radiobiology, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
关键词:
辐射电离RNA长链非编码损伤应答
Keywords:
Radiation ionizingRNA long noncodingDamage response
DOI:
10.3760/cma.j.issn.1673-4114.2018.02.011
摘要:
长链非编码RNA (lncRNAs)是一类新的功能分子,可通过影响基因转录、蛋白质翻译以及蛋白质稳定性等方式调节下游靶基因,在生长发育、免疫应答、代谢调控以及肿瘤形成等生物学事件中发挥重要作用。已有研究表明lncRNAs可以通过电离辐射诱导表达,并参与细胞对电离辐射的应答反应以及细胞损伤修复过程。通过对电离辐射相关lncRNAs的研究有助于加深对电离辐射损伤应答机制的认识和了解。笔者对lncRNAs的结构功能、调控靶基因方式以及对电离辐射相关lncRNAs的功能和作用方式进行综述。
Abstract:
Long noncoding RNAs (lncRNAs) are emerging functional molecules that can regulate downstream target genes by influencing genetic transcription and protein translation and stability. LncRNAs play an important role in various biological processes, such as growth and development, immune response, metabolic regulation, and oncogenesis. Ionizing radiation can induce the expression of lncRNAs that can participate in ionizing radiation-induced damage response and repair. Thus, studying lncRNAs related to ionizing radiation is helpful in enriching our understanding of the mechanisms of damage response. Herein, we aimed to review the structures, functions, and target gene regulatory mechanisms of lncRNAs in ionizing radiation.

参考文献/References:

[1] Mercer TR, Dinger ME, Mattick JS.Long non-coding RNAs:insights into functions[J]. Nat Rev Genet, 2009,10(3):155-159. DOI:10.1038/nrg2521.
[2] Anderson DM, Anderson KM, Chang CL, et al. A micropeptide encoded by a putative long non-coding RNA regulates muscle performance[J]. Cell, 2015, 160(4):595-606. DOI:10.1016/j.cell.2015.01.009.
[3] Wilusz JE, Sunwoo H, Spector DL.Long noncoding RNAs:functional surprises from the RNA world[J]. Genes Dev, 2009, 23(13):1494-1504. DOI:10.1101/gad.1800909.
[4] Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs[J]. Cell, 2009, 136(4):629-641. DOI:10.1016/j.cell.2009.02.006.
[5] Ransohoff JD, Wei Y, Khavari PA. The functions and unique features of long intergenic non-coding RNA[J]. Nat Rev Mol Cell Biol, 2018, 19(3):143-157. DOI:10.1038/nrm.2017.104.
[6] Smith MA, Gesell T, Stadler PF, et al. Widespread purifying selection on RNA structure in mammals[J]. Nucleic Acids Res,2013, 41(17):8220-8236. DOI:10.1093/nar/gkt596.
[7] Melissari MT, Grote P. Roles for long non-coding RNAs in physiology and disease[J]. Pflugers Arch, 2016, 468(6):945-958. DOI:10.1007/s00424-016-1804-y.
[8] Guttman M, Amit I, Garber M, et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals[J]. Nature, 2009, 458(7235):223-227. DOI:10.1038/nature07672.
[9] Chen LL, Carmichael GG. Long noncodin g RNAs in mammalian cells:what, where, and why?[J]. Wiley Interdiscip Rev RNA, 2010, 1(1):2-21. DOI:10.1002/wrna.5.
[10] Mchugh CA, Chen CK, Chow A, et al. The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3[J].Nature, 2015, 521(7551):232-236. DOI:10.1038/nature14443.
[11] Zhou JC, Yang LH, Zhong TY, et al. H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase[J]. Nat Commun, 2015, 6:10221. DOI:10.1038/ncomms 10221.
[12] Huang YP, Zheng YF, Jin CY, et al. Long non-coding RNA H19 inhibits adipocyte differentiation of bone marrow mesenchymal stem cells through epigenetic modulation of histone deacetylases[J]. Sci Rep, 2016, 628(6):28897. DOI:10.1038/srep28897.
[13] Morris KV, Sharon S, Turner AM, et al. Bidirectional transcription directs both transcriptional gene activation and suppression in human cells[J/OL]. PLoS Genet, 2008, 4(11):e1000258[2018-01-20].http://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000258&type=printable. DOI:10.1371/journal.pgen.1000258.
[14] Martens JA, Laprade L, Winston F. Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene[J]. Nature, 2004, 429(6991):571-574. DOI:10.1038/nature02538.
[15] Tripathi V, Ellis JD, Shen Z, et al.The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation[J]. Mol Cell, 2010, 39(6):925-938.DOI:10.1016/j.molcel.2010.08.011.
[16] Hirose T, Virnicchi G, Tanigawa A, et al. NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies[J]. Mol Biol Cell, 2014, 25(1):169-183. DOI:10.1091/mbc.E13-09-0558.
[17] Angrand PO, Vennin C, Le Bourhis XL. The role of long non-coding RNAs in genome formatting and expression[J]. Front Genet, 2015, 429(6):165. DOI:10.3389/fgene.2015.00165.
[18] Deckbar D, Jeggo PA, Löbrich M.Understanding the limitations of radiation-induced cell cycle checkpoints[J]. Crit Rev Biochem Mol Biol, 2011, 46(4):271-283. DOI:10.3109/10409238. 2011.575764.
[19] Warmerdam DO, Kanaar R. Dealing with DNA damage:Relationships between checkpoint and repair pathways[J]. Mutat Res, 2010, 704(1/3):2-11. DOI:10.1016/j.mrrev.2009.12.001.
[20] Liu X, Li D, Zhang W, et al. Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay[J]. EMBO J, 2012, 31(23):4415-4427. DOI:10.1038/emboj.2012.292.
[21] Wang X, Arai S, Song X, et al. Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription[J]. Nature, 2008, 454(720):126-130. DOI:10.1038/nature06992.
[22] Zhang M, Gao C, Yang Y, et al. Long noncoding RNA CRNDE/PRC2 participated in the radiotherapy resistance of human lung adenocarcinoma through targeting p21 expression[J]. Oncol Res, 2017. DOI:10.3727/096504017X14944585873668.
[23] Jiang Y, Li Y, Fang S, et al. The role of MALAT1 correlates with HPV in cervical cancer[J]. Oncol Lett, 2014, 7(6):2135-2141. DOI:10.3892/ol.2014.1996.
[24] Wang J, Su L, Chen X, et al. MALAT1 promotes cell proliferation in gastric cancer by recruiting SF2/ASF[J]. Biomed Pharmacother, 2014, 68(5):557-564. DOI:10.1016/j.biopha.2014.04.007.
[25] Lu H, He Y, Lin L, et al.Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145[J]. Tumour Biol, 2016, 37(2):1683-1691. DOI:10.1007/s13277-015-3946-5.
[26] Prensner JR, Chen W, Iyer MK, et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer[J]. Cancer Res, 2014, 74(6):1651-1660. DOI:10.1158/0008-5472. CAN-13-3159.
[27] Zhang Y, He Q, Hu Z, et al. Long noncoding RNA LINP1 regulates double strand DNA break repair in triple negative breast cancer[J].Nat Struct Mol Biol, 2016,23(6):522-530. DOI:10.1038/nsmb.3211.
[28] Sharma V, Khurana S, Kubben N, et al. A BRCA1-interacting lncRNA regulates homologous recombination[J]. EMBO Rep, 2015, 16(11):1520-1534. DOI:10.15252/embr.201540437.
[29] Wan G, Hu X, Liu Y, et al. A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation[J]. EMBO J, 2013, 32(21):2833-2847. DOI:10.1038/emboj.2013.221.
[30] Wang G, Li Z, Zhao Q, et al. LincRNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/β-catenin signaling pathway[J]. Oncol Rep, 2014, 31(4):1839-1845. DOI:10.3892/or.2014.3047.
[31] Shen Y, Liu Y, Sun T, et al. LincRNA-p21 knockdown enhances radiosensitivity of hypoxic tumor cells by reducing autophagy through HIF-1/Akt/mTOR/P70S6K pathway[J]. Exp Cell Res, 2017, 358(2):188-198. DOI:10.1016/j.yexcr.2017.06.016.
[32] Wan GH, Mathur R, Hu XX, et al. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway[J].Cell Signal, 2013, 25(5):1086-1095. DOI:10.1016/j.cellsig.2013. 02.006.
[33] Hu XG, Jiang HJ, Jiang XJ. Downregulation of lncRNA ANRIL inhibits proliferation, induces apoptosis, and enhances radiosensitivity in nasopharyngeal carcinoma cells through regulating miR-125a[J]. Cancer Biol Ther, 2017, 18(5):331-338.DOI:10.1080/15384047.2017.1310348.
[34] Hung T, Wang Y, Lin MF, et al. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters[J]. Nat Genet, 2011, 43(7):621-629. DOI:10.1038/ng.848.
[35] O’leary VB, Ovsepian SV, Carrascosa LG, et al. PARTICLE, a triplex-forming long ncRNA, regulates locus-specific methylation in response to low-dose irradiation[J]. Cell Rep, 2015, 11(3):474-485. DOI:10.1016/j.celrep.2015.03.043.
[36] Tan JM, Qiu KF, Li MY, et al. Double-negative feedback loop between long non-coding RNA TUG1 and miR-145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells[J]. FEBS Lett, 2015, 589(20 Pt B):3175-3181.DOI:10.1016/j.febslet.2015.08.020.

相似文献/References:

[1]徐畅,方连英,孔阳阳,等.沉默BLAP75基因对电离辐射诱导DNA损伤的影响[J].国际放射医学核医学杂志,2016,40(4):244.[doi:10.3760/cma.j.issn.1673-4114.2016.04.001]
 Xu Chang,Fang Lianying,Kong Yangyang,et al.Effects of silencing BLAP75 on DNA damage induced by ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):244.[doi:10.3760/cma.j.issn.1673-4114.2016.04.001]
[2]董娟聪,刘红艳,党旭红,等.12c重离子与γ射线对人外周血淋巴细胞peng-ebv增殖、细胞周期及凋亡影响的比较[J].国际放射医学核医学杂志,2015,39(5):385.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 007]
 dong juancong,liu hongyan,dang xuhong,et al.effects of 12c heavy ion and γ ray irradiation in cell growth, cell cycle and apoptosis of human peripheral blood lymphocytes[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):385.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 007]
[3]李晴,王璐,徐畅,等.姜油树脂对辐射后间充质干细胞nrf2及其靶基因表达的影响[J].国际放射医学核医学杂志,2015,39(5):389.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 008]
 li Qing,wang lu,xu chang,et al.ginger oleoresin induced expression of nrf2 and its target genes in mesenchymal stem cells after radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):389.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 008]
[4]徐金苹,袁德晓,张江虹,等.辐射诱导的外泌体在肿瘤细胞侵袭转移中的作用[J].国际放射医学核医学杂志,2015,39(2):144.[doi:10.3760/cma.j.issn.1673-4114.2015.02.009]
 Xu Jinping,Yuan Dexiao,Zhang Jianghong,et al.The role of radiation-induced exosomes in tumor invasion and metastasis[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):144.[doi:10.3760/cma.j.issn.1673-4114.2015.02.009]
[5]王芹,王敬敏,徐畅,等.沉默XRCC2基因表达联合电离辐射对结肠癌细胞增殖能力的影响[J].国际放射医学核医学杂志,2015,39(4):282.[doi:10.3760/cma.j.issn.1673-4114.2015.04.002]
 Wang Qin,Wang Jingmin,Xu Chang,et al.The effect of silencing XRCC2 gene combined with ionizing radiation on growth of colorectal cancer cells[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):282.[doi:10.3760/cma.j.issn.1673-4114.2015.04.002]
[6]施常备,许建林,袁勇,等.染色体畸变率估算32P的辐射剂量[J].国际放射医学核医学杂志,2012,36(1):35.[doi:10.3760/cma.j.issn.1673-4114.2012.01.009]
 SHI Chang-bei,XU Jian-lin,YUAN Yong,et al.The quantitative radiation dose of 32P by chromosomal aberration[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(2):35.[doi:10.3760/cma.j.issn.1673-4114.2012.01.009]
[7]赵欣然,江波,傅宝华,等.《过量照射人员的医学检查与处理原则》解读[J].国际放射医学核医学杂志,2012,36(4):207.[doi:10.3760/cma.j.issn.1673-4114.2012.04.003]
 ZHAO Xin-ran,JIANG Bo,FU Bao-hua,et al.Explanation of Medical Examination and Management Principle for the Overexposed Individuals[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(2):207.[doi:10.3760/cma.j.issn.1673-4114.2012.04.003]
[8]刘玉龙,姜忠.《核事故场内医学应急响应程序》解读[J].国际放射医学核医学杂志,2012,36(4):218.[doi:10.3760/cma.j.issn.1673-4114.2012.04.006]
 LIU Yu-long,JIANG Zhong.Explanation of Procedure on Site Medical Emergency Response for Nuclear Accident[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(2):218.[doi:10.3760/cma.j.issn.1673-4114.2012.04.006]
[9]刘强,王彦,杜利清,等.《单细胞凝胶电泳用于受照人员剂量估算技术规范》解读[J].国际放射医学核医学杂志,2012,36(4):242.[doi:10.3760/cma.j.issn.1673-4114.2012.04.012]
 LIU Qiang,WANG Yan,DU Li-qing,et al.Explanation for the Specification of Dose Estimation for the Radiation Victims in the Early Stage Using Single Cell Gel Electrophoresis[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(2):242.[doi:10.3760/cma.j.issn.1673-4114.2012.04.012]
[10]刘强,王彦.ICRP118关于辐射诱导组织反应内容的部分修改建议[J].国际放射医学核医学杂志,2013,37(6):389.[doi:10.3760/cma.j.issn.1673-4114.2013.06.016]
 LIU Qiang,WANG Yan.Revision recommendations of tissue reaction induced by radiation in ICRP118[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):389.[doi:10.3760/cma.j.issn.1673-4114.2013.06.016]
[11]张宇睿,徐文清.电离辐射对线粒体损伤的研究进展[J].国际放射医学核医学杂志,2016,40(2):154.[doi:10.3760/cma.j.issn.1673-4114.2016.02.014]
 Zhang Yurui,Xu Wenqing.Damages of ionizing radiation on mitochondria[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):154.[doi:10.3760/cma.j.issn.1673-4114.2016.02.014]
[12]张俊伶,薛晓蕾,李源,等.富氢水对电离辐射引起胸腺细胞损伤的影响[J].国际放射医学核医学杂志,2015,39(5):358.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 001]
 zhang junling,xue xiaolei,li yuan,et al.effects of hydrogen-rich water on radiation-induced thymus injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):358.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 001]
[13]付岳,王彦,杜利清,等.sirt1基因沉默在辐射诱导的nlrp3和il-1β表达中的作用研究[J].国际放射医学核医学杂志,2015,39(5):367.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 003]
 fu yue*,wang yan,du liqing,et al.effects of nlrp3 and il-1β on radiation-induced expression through sirt1 gene silencing[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):367.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 003]
[14]刘建功,党旭红,刘红艳,等.核工业某厂放射工作人员与非放射工作人员的mdm2基因表达调查与分析[J].国际放射医学核医学杂志,2015,39(5):416.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 015]
 liu jiangong,dang xuhong,liu hongyan,et al.investigation and analysis of mdm2 expression level in radiation-exposed workers and non-radiation-exposed workers[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):416.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 015]
[15]王璐,李晴,徐畅,等.sirna干扰sirt1对辐射后il-6表达的影响[J].国际放射医学核医学杂志,2015,39(5):423.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 017]
 wang lu,li Qing,xu chang,et al.effect of sirt1 sirna interference on the expression of il-6 after radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):423.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 017]
[16]张倩如,李海涛,田红旗.小分子辐射防护药物的研究进展[J].国际放射医学核医学杂志,2016,40(5):394.[doi:10.3760/cma.j.issn.1673-4114.2016.05.012]
 Zhang Qianru,Li Haitao,Tian Hongqi.Small molecule compounds against radiation:research advances[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):394.[doi:10.3760/cma.j.issn.1673-4114.2016.05.012]
[17]肖林林,金问森,张江虹,等.电离辐射诱发动脉粥样硬化的研究进展[J].国际放射医学核医学杂志,2015,39(6):493.[doi:10.3760/cma.j.issn.1673-4114.2015.06.012]
 Xiao Linlin,Jin Wensen,Zhang Jianghong,et al.Research progress of radiation induced atherosclerosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):493.[doi:10.3760/cma.j.issn.1673-4114.2015.06.012]
[18]张俊伶,路璐,李德冠,等.基因芯片表达分析4Gyγ射线对小鼠骨髓c-kit阳性细胞影响[J].国际放射医学核医学杂志,2015,39(2):116.[doi:10.3760/cma.j.issn.1673-4114.2015.02.003]
 Zhang Junling,Lu Lu,Li Deguan,et al.Expression changes of genes in c-kit positive cells after 4Gy γ-ray irradiation: agene chip analysis[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):116.[doi:10.3760/cma.j.issn.1673-4114.2015.02.003]
[19]范美婷,马云,何淑雅.耐辐射奇球菌中多效蛋白PprA功能的研究进展[J].国际放射医学核医学杂志,2015,39(2):149.[doi:10.3760/cma.j.issn.1673-4114.2015.02.010]
 Fan Meiting,Ma Yun,He Shuya.Research progress and prediction on pleiotropic protein PprA from Deinococcus radiodurans[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):149.[doi:10.3760/cma.j.issn.1673-4114.2015.02.010]
[20]李敏,贺欣,周则卫,等.BTG2作为一种新的电离辐射诱导基因的研究[J].国际放射医学核医学杂志,2014,38(2):71.[doi:10.3760/cma.j.issn.1673-4114.2014.02.001]
 Li Min,He Xin,Zhou Zewei,et al.Study on B-cell translocation gene 2 as a novel radiation-induced gene[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(2):71.[doi:10.3760/cma.j.issn.1673-4114.2014.02.001]

备注/Memo

备注/Memo:
收稿日期:2018-01-25。
基金项目:国家自然科学基金面上项目(81573083,31770913)
通讯作者:王治东,Email:wangzhidong1977@126.com
更新日期/Last Update: 2018-05-09