[1]杨小丰,居热提·阿扎提,曹务成,等.肺癌患者体重、血糖浓度和病灶大小对18F-FDG PET/CT病灶SUV的影响[J].国际放射医学核医学杂志,2013,37(4):211-215.[doi:10.3760/cma.j.issn.1673-4114.2013.04.006]
　YANG Xiao-feng,JURETI-Azhati,CAO Wu-cheng,et al.The effect of lung cancer patients’ weight, blood glucose concentration and lesion size of lung cancer on 18F-FDG PET/CT lesions SUV results[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(4):211-215.[doi:10.3760/cma.j.issn.1673-4114.2013.04.006]
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肺癌患者体重、血糖浓度和病灶大小对18F-FDG PET/CT病灶SUV的影响(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第4期
页码:
211-215
栏目:
论著
出版日期:
2013-07-25

文章信息/Info

Title:
The effect of lung cancer patients’ weight, blood glucose concentration and lesion size of lung cancer on 18F-FDG PET/CT lesions SUV results
作者:
杨小丰1;  居热提·阿扎提1;  曹务成1;  柴黎明1;  辛军2;  李宏利3;  赵周社3
1. 830001 乌鲁木齐, 新疆维吾尔自治区人民医院核医学科;
2. 110004 沈阳, 中国医科大学附属盛京医院医学影像中心;
3. 214000 无锡, 美国通用电气医疗集团(中国)
Author(s):
YANG Xiao-feng1;  JURETI-Azhati1;  CAO Wu-cheng1;  CHAI Li-ming1;  XIN Jun2;  LI Hong-li3;  ZHAO Zhou-she3
Department of Nuclear Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
关键词:
肺肿瘤; 氟脱氧葡萄糖F18; 正电子发射断层显像术; 体层摄影术; X线计算机; 标准化摄取值
Keywords:
Lung neoplasms; Fluorodeoxyglucose F18; Positron-emission tomography; Tomography; X-ray computed; Standardized uptake value
DOI:
10.3760/cma.j.issn.1673-4114.2013.04.006
摘要:
目的 研究肺癌患者体重、血糖浓度和病灶大小对18F-FDG PET/CT病灶SUV的影响。方法 50例无糖尿病病史的肺癌患者中,21例有纵隔转移灶。所有患者均行常规18F-FDG PET/CT,使用Advantage Workstation图像处理工作站自动提取肺癌病灶SUV以及经过体重和体型校正的SUV。采用半自动方法提取肝脏参考本底SUV。肺癌原发灶和转移灶诊断参考标准按照肝脏参考本底SUV或体型校正SUV×1.5+2×标准差。结果 50例肺癌患者血糖浓度与肝脏参考本底SUV之间呈正相关,与肺癌原发灶SUV呈负相关,但是与转移灶SUV之间却呈正相关。按照参考诊断标准,50个肺癌原发灶和21个肺癌转移灶经过血糖浓度、病灶大小进行校正前和校正后,临床诊断的准确率分别为90.00%、71.43%和100%、95.24%。结论 患者体重、血糖浓度和病灶大小对肺癌临床诊断准确率具有显著影响。经过血糖浓度、病灶大小校正后临床对肺癌诊断的准确率明显提高。这些结果提示,行18F-FDG PET/CT诊断肺癌时,需要高度重视患者体重、血糖浓度和病灶大小对结果的影响。
Abstract:
Objective To study the effects of lung cancer patients’ weight,blood glucose concentration and lesion size of lung cancer on 18F-FDG PET/CT lesions SUV results.Methods Fifty cases of lung cancer patients without a history of diabetes mellitus were enrolled in this study.Among them,21 patients with mediastinal metastases were detected.According to clinical routine 18F-FDG PET/CT scanning,automatic extraction of lung cancer SUV,weight and size correction SUV were obtained using the GE Advantage Workstation image processing workstation.Liver reference background SUV was obtained using semiautomatic extraction method of extraction.Lung cancer primary tumors and metastatic lesions diagnosis reference standards were accordant with the liver reference background SUV or SUV shape correction×1.5+2×standard deviation.Results Fifty cases of lung cancer in patients with blood sugar concentration and liver reference background SUV had positive correlation with lung cancer,SUV of primary lung cancer was negatively correlated with blood sugar,but it showed a positive correlation between blood sugar and lung metastases.According to the reference criteria for the diagnosis of 50 primary lung cancer cases and 21 metastatic lung cancer cases before and after the clinical diagnosis,the glucose concentration,lesion size correction accuracies were 90.00%,71.43% and 100%,95.24% respectively.Conclusions Patients’ body weight,blood glucose concentration and lesion size significantly affect the accuracy of clinical diagnosis of lung cancer.After correction accuracy,it remarkably improved the clinical diagnosis of lung cancer.The results suggest that when using 18F-FDG PET/CT for lung cancer diagnosis,the effects of body weight,blood glucose concentration and lesion size should be concerned.

参考文献/References:

[1] Adams MC, Turkington TG, Wilson JM, et al. A systematic review of the factors affecting accuracy of SUV measurements. AJR Am J Roentgenol,2010, 195(2):310-320.
[2] Kubota K, Watanabe H, Murata Y, et al. Effects of blood glucose level on FDG uptake by liver:a FDG-PET/CT study. Nucl Med Biol, 2011,38(3):347-351.
[3] Kaneta T, Hakamatsuka T, Takanami K, et al. Evaluation of the relationship between physiological FDG uptake in the heart and age, blood glucose level, fasting period, and hospitalization. Ann Nucl Med, 2006,20(3):203-208.
[4] Hadi M, Bacharach SL, Whatley M, et al. Glucose and insulin variations in patients during the time course of a FDG-PET study and implications for the "glucose-corrected" SUV. Nucl Med Biol, 2008, 35(4):441-445.
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备注/Memo

备注/Memo:
收稿日期:2012-08-03。
通讯作者:杨小丰,Email:yangxf5100@126.com
更新日期/Last Update: 1900-01-01