[1]曹登敏,林美福,陈文新,等.继发性骨淋巴瘤的18F-FDG PET/CT影像学表现[J].国际放射医学核医学杂志,2016,40(6):403-407.[doi:10.3760/cma.j.issn.1673-4114.2016.06.001]
　Cao Dengmin,Lin Meifu,Chen Wenxin,et al.Analysis on 18F-FDG PET/CT imaging characteristics in secondary bone lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(6):403-407.[doi:10.3760/cma.j.issn.1673-4114.2016.06.001]
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继发性骨淋巴瘤的18F-FDG PET/CT影像学表现(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第6期
页码:
403-407
栏目:
论著
出版日期:
2016-11-25

文章信息/Info

Title:
Analysis on 18F-FDG PET/CT imaging characteristics in secondary bone lymphoma
作者:
曹登敏;  林美福;  陈文新;  陈彩龙;  周硕
350001 福州, 福建医科大学省立临床医学院, 福建省立医院核医学科
Author(s):
Cao Dengmin;  Lin Meifu;  Chen Wenxin;  Chen Cailong;  Zhou Shuo
Department of Nuclear Medicine, Fujian Provincial Hospital, Provincial Clinical Hospital of Fujian Medical University, Fuzhou 350001, China
关键词:
氟脱氧葡萄糖F18; 正电子发射断层显像术; 体层摄影术; X线计算机; 继发性骨淋巴瘤
Keywords:
Fluorodeoxyglucose F18; Positron-emission tomography; Tomography;  X-ray computed; Secondary bone lymphoma
DOI:
10.3760/cma.j.issn.1673-4114.2016.06.001
摘要:
目的 探讨继发性骨淋巴瘤在18F-FDG PET/CT显像中的影像学特点。方法 对2012年4月至2015年6月行全身18F-FDG PET/CT显像的46例继发性骨淋巴瘤患者的PET/CT影像学表现进行回顾性分析。并将骨髓穿刺结果分为阳性和阴性两组，对两组显像相应穿刺部位（髂棘） SUV进行独立样本t检验，同时绘制穿刺部位SUV诊断继发性骨淋巴瘤的受试者工作特征曲线（ROC）。结果 46例继发性骨淋巴瘤患者中，霍奇金淋巴瘤6例、非霍奇金淋巴瘤40例；单发10例，多发18例，全身弥漫分布18例。46例患者骨质异常表现多样，其中，骨髓浸润型31例（67.40%）、混合型10例（21.74%）、硬化型3例（6.52%）、溶骨型2例（4.34%）。46例患者中肱骨或股骨受累32例（69.57%），均为骨髓浸润型表现。骨髓穿刺阳性组及阴性组SUV独立样本t检验结果显示t=4.036，P<0.001，提示两组差异有统计学意义。穿刺部位SUV诊断继发性骨淋巴瘤的ROC曲线结果显示SUV诊断界值为2.35，其诊断继发性骨淋巴瘤的特异度和灵敏度分别为83.3%和80.0%。结论 继发性骨淋巴瘤的18F-FDG PET/CT影像学表现存在一定的特征性，在该病的诊断与鉴别诊断中具有重要的临床价值，且对骨髓穿刺部位的选择具有指导意义。
Abstract:
Objective To investigate the 18F-FDG PET/CT imaging characteristics in secondary bone lymphoma. Methods A total of 46 patients with 18F-FDG PET/CT imaging of secondary bone lymphoma from April 2012 to June 2015 were selected; the PET/CT imaging characteristics were retrospectively analyzed. The patients were divided according to the results of their bone marrow biopsies:negative and positive groups. The SUV of the biopsy sites in 18F-FDG PET/CT imaging between the two groups were compared by independent sample t test, and the receiver operating characteristic curve(ROC) of the SUV in the puncture sites in the diagnosis of secondary bone lymphoma was drawn. ResultsThe 46 cases of secondary bone lymphoma included 6 cases of Hodgkin’s lymphoma and 40 cases of non-Hodgkin’s lymphoma. The cases comprised 10 cases of single bone lesion, 18 cases of multiple bone lesions, and 18 cases of diffuse bone lesions in the whole body. The bone densities of the 46 cases were abnormal with the following conditions:31 cases of bone marrow infiltration type(67.40%), 10 cases of mixed type(21.74%), 3 cases of sclerosis type(6.52%), and 2 cases of osteolysis type(4.34%); 32 cases of humeral or femoral involvement(69.57%) with the bone marrow infiltration type was included. The independent sample t-test in the negative and positive groups showed a t value of 4.036, P<0.001, revealing that the difference was statistically significant. The ROC curve of the SUV in the puncture sites in the diagnosis of secondary bone lymphoma showed a cut-off value of 2.35; the specificity and sensitivity of the diagnosis of secondary bone lymphoma were 83.3% and 80.0%, respectively. Conclusions The PET/CT imaging features of secondary bone lymphoma showed certain characteristics that are important and of clinical value to the diagnosis and differential diagnosis of secondary bone lymphoma, thus revealing that it has instructional significance for choosing biopsy sites.

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备注/Memo

备注/Memo:
收稿日期:2016-09-20。
通讯作者:陈文新,Email:wenxinchzt@aliyun.com
更新日期/Last Update: 1900-01-01