[1]李菲,黄俊星,张俊.18F-FDG PET/CT在食管癌中的临床应用[J].国际放射医学核医学杂志,2016,40(4):282-286.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
 Li Fei,Huang Junxing,Zhang Jun.The clinical application of 18F-FDG PET/CT in esophageal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):282-286.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
点击复制

18F-FDG PET/CT在食管癌中的临床应用(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第4期
页码:
282-286
栏目:
出版日期:
2016-07-25

文章信息/Info

Title:
The clinical application of 18F-FDG PET/CT in esophageal cancer
作者:
李菲 黄俊星 张俊
225300, 泰州市人民医院肿瘤科(南通大学第五附属医院)
Author(s):
Li Fei Huang Junxing Zhang Jun
Department of Oncology, Taizhou People’s Hospital(the Fifth Affiliated Hospital of Nantong University), Nantong 225300, China
关键词:
食管肿瘤正电子发射断层显像术体层摄影术 X线计算机氟脱氧葡萄糖F18
Keywords:
Esophageal neoplasmsPositron-emission tomographyTomography X-ray computerFluorodeoxyglucose F18
DOI:
10.3760/cma.j.issn.1673-4114.2016.04.009
摘要:
食管癌在我国具有较高的发病率和病死率,且病死率较发病率的排序靠前,表明该病在诊断及治疗方面仍存在很多问题。目前食管癌的诊断主要包括消化道造影、内镜活检、CT等。PET/CT作为一种新型检查方法,突破了传统检查的禁锢,将代谢图像和CT图像融合,在食管癌诊断、分期、疗效评价及预后判断等方面显示出了独特的应用价值。笔者将对18F-FDG PET/CT在食管癌中的最新研究进展进行综述。
Abstract:
Esophageal cancer has high incidence and mortality rates in our country. The number of mortality is greater than that of incidence, thus indicating that many problems still occur in esophageal cancer diagnosis and treatment. The present diagnosis of esophageal cancer includes gastrointestinal angiography, endoscopic biopsy, and CT, among others. As a new method, PET/CT breaks through the limitation of traditional inspection by combining the metabolic and CT images. This combination has a unique value in diagnosis, tumor staging, efficacy evaluation, prognosis, and other aspects of esophageal cancer. This article reviews the latest research.

参考文献/References:

[1] Parkin DM, Bray F, Ferlay J, et al.Global cancer statistics, 2002[J].CA Cancer J Clin, 2005, 55(2): 74-108.DOI: 10.3322/canjclin.55.2.74.
[2] Lee MS, Mamon HJ, Hong TS, et al.Preoperative cetuximab, irinotecan, cisplatin, and radiation therapy for patients with locally advanced esophageal cancer[J].Oncologist, 2013, 18(3): 281-287.DOI: 10.1634/theoncologist.2012-0208.
[3] Lee DH, Kim HR, Kim DK, et al.Outcomes of cervical lymph node recurrence in patients with esophageal squamous cell carcinoma after esophagectomy with 2-field lymph node dissection[J].J Thorac Cardiovasc Surg, 2013, 146(2): 365-371.DOI: 10.1016/j.jtcvs.2013.01.043.
[4] 陈俊强, 李建成, 朱坤寿, 等.食管癌转移淋巴结大小和肿瘤浸润深度对18F-FDG SPET/CT诊断准确性的影响[J].肿瘤基础与临床, 2011, 24(1): 54-57.DOI: 10.3969/j.issn.1673-5412.2011.01.024.Chen JQ, Li JC, Zhu KS, et al.The influnce of Esophageal cancer metastasis lymph node size, and tumor infiltration depth on diagnostic accuracy of 18F-FDG SPET/CT[J].J Basic Clin Oncol, 2011, 24(1): 54-57.
[5] Pfau PR, Perlman SB, Stanko P, et al.The role and clinical value of EUS in a multimodality esophageal carcinoma staging program with CT and positron emission tomography[J].Gastrointest Endosc, 2007, 65(3): 377-384.DOI: 10.1016/j.gie.2006.12.015.
[6] Shimpi RA, George J, Jowell P, et al.Staging of esophageal cancer by EUS: staging accuracy revisited[J].Gastrointest Endosc, 2007, 66(3): 475-482.DOI: 10.1016/j.gie.2007.03.1051.
[7] Heeren PA, Van Westreenen HL, Geersing GJ, et al.Influence of tumor characteristics on the accuracy of endoscopic ultrasonography in staging cancer of the esophagus and esophagogastric junction[J].Endoscopy, 2004, 36(11): 966-971.DOI: 10.1055/s-2004-825956.
[8] Rollins KE, Lucas E, Tewari N, et al.PET-CT offers accurate assessment of tumour length in oesophageal malignancy[J].Eur J Radiol, 2015, 84(2): 195-200.DOI: 10.1016/j.ejrad.2014.10.014.
[9] Cuellar SL, Carter BW, Macapinlac HA, et al.Clinical staging of patients with early esophageal adenocarcinoma: does FDG-PET/CT have a role?[J].J Thorac Oncol, 2014, 9(8): 1202-1206.DOI: 10.1097/JTO.0000000000000222.
[10] Manabe O, Hattori N, Hirata K, et al.Diagnostic accuracy of lymph node metastasis depends on metabolic activity of the primary lesion in thoracic squamous esophageal cancer[J].J Nucl Med, 2013, 54(5): 670-676.DOI: 10.2967/jnumed.112.110304.
[11] Yu W, Fu XL, Zhang YJ, et al.A prospective evaluation of staging and target volume definition of lymph nodes by 18FDG PET/CT in patients with squamous cell carcinoma of thoracic esophagus.[J/OL].Int J Radiat Oncol Biol Phys, 2011, 81(5): e759-765[2016-02-14].http: //www.ncbi.nlm.nih.gov/pubmed/21470788.DOI: 10.1016/j.ijrobp.2010.10.065.
[12] 李军凯, 左效艳, 许文, 等.PET/CT对于食管癌放射治疗的研究进展[J].中国医药导刊, 2012, 14(8): 1311-1313.DOI: 10.3969/j.issn.1009-0959.2012.08.013.Li JK, Zuo XY, Xu W, et al.The research progress of PET/CT for esophageal cancer radiotherapy[J].Chin J Med Guide, 2012, 14(8): 1311-1313.
[13] 叶雪梅, 张春燕, 章晨, 等.18F-FDG SPECT/CT显像在食管癌治疗前分期诊断中的应用价值[J].肿瘤学杂志, 2012, 18(10): 762-767.Ye XM, Zhang CY, Zhang C, et al.The application value of 18F-FDG SPECT/CT imaging in the diagnosis of esophageal cancer treatment before staging[J].J Oncol, 2012, 18(10): 762-767.
[14] Shi WD, Wang WC, Wang J, et al.Meta-analysis of (18)FDG PET-CT for nodal staging in patients with esophageal cancer[J].Surg Oncol, 2013, 22(2): 112-116.DOI: 10.1016/j.suronc.2013.02.003.
[15] Domínguez LM, Rayo JI, Serrano J, et al.Uncommon isolated distant subcutaneous tissue and skeletal muscle metastasis from oesophageal cancer diagnosed by 18F-FDG PET/CT[J].Rev Esp Med Nucl Imagen Mol, 2016, 35(1): 38-41.DOI: 10.1016/j.remn.2015.07.005.
[16] Malik V, Johnston C, Donohoe C, et al.18F-FDG PET-detected synchronous primary neoplasms in the staging of esophageal cancer: incidence, cost, and impact on management[J].Clin Nucl Med, 2012, 37(12): 1152-1158.DOI: 10.1097/RLU.0b013e31827083ba.
[17] Shum WY, Hsieh TC, Yeh JJ, et al.Clinical usefulness of dual-time FDG PET-CT in assessment of esophageal squamous cell carcinoma[J].Eur J Radiol, 2012, 81(5): 1024-1028.DOI: 10.1016/j.ejrad.2011.03.018.
[18] Chen SH, Chan SC, Chao YK, et al.Detection of synchronous cancers by fluorodeoxyglucose positron emission tomography/computed tomography during primary staging workup for esophageal squamous cell carcinoma in Taiwan[J/OL].PLoS One, 2013, 8(11): e82812[2016-02-14].http: //journals.plos.org/plosone/article?id=10.1371/journal.pone.0082812.DOI: 10.1371/journal.pone.0082812.
[19] Miyazaki T, Sohda M, Higuchi T, et al.Effectiveness of FDG-PET in screening of synchronous cancer of other organs in patients with esophageal cancer[J].Anticancer Res, 2014, 34(1): 283-287.
[20] 王胜军, 杨卫东, 赵小虎, 等.18F-FDG PET/CT诊断多发癌的价值[J].国际放射医学核医学杂志, 2013, 37(2): 96-99.DOI: 10.3760/cma.j.issn.1673-4114.2013.02.009.Wang SJ, Yang WD, Zhao XH, et al.Value of 18F-FDG PET/CT in the diagnosis of multiple primary malignant neoplasms[J].Int J Radiat Med Nucl Med, 2013, 37(2): 96-99.
[21] 任宝志, 钟立松, 袁建军.18FDG PET/CT定位三维适形放疗食管癌的疗效和预后分析[J].中国肿瘤临床与康复, 2010, 17(4): 338-341.DOI: 10.1021/la101229p.Ren BZ, Zhong LS, Yuan JJ, et al.Analysis of the curative effect and prognosis of esophageal cancer in three-dimensional conformal radiotherapy positioning of 18FDG PET/CT[J].Chin J Clin Oncol Rehabil, 2010, 17(4): 338-341.
[22] Seol KH, Lee JE.PET/CT planning during chemoradiotherapy for esophageal cancer[J].Radiat Oncol J, 2014, 32(1): 31-42.DOI: 10.3857/roj.2014.32.1.31.
[23] Muijs CT, Beukema JC, Woutersen DA, et al.Clinical validation of FDG-PET/CT in the radiation treatment planning for patients with oesophageal cancer[J].Radiather Oncol, 2014, 113(2): 188-192.DOI: 10.1016/j.radonc.2014.10.016.
[24] Pan L, Gu P, Huang G, et al.Prognostic significance of SUV on PET/CT in patients with esophageal cancer: a systematic review and meta-analysis[J].Eur J Gastroenterol Hepatol, 2009, 21(9): 1008-1015.DOI: 10.1097/MEG.0b013e328323d6fa.
[25] Elimova E, Wang X, Etchebehere E, et al.18-fluorodeoxy-glucose positron emission computed tomography as predictive of response after chemoradiation in oesophageal cancer patients[J].Eur J Cancer, 2015, 51(17): 2545-2552.DOI: 10.1016/j.ejca.2015.07.044.
[26] Metser U, Rashidi F, Moshonov H, et al.18F-FDG-PET/CT in assessing response to neoadjuvant chemoradiotherapy for potentially resectable locally advanced esophageal cancer[J].Ann Nucl Med, 2014, 28(4): 295-303.DOI: 10.1007/s12149-014-0812-2.
[27] Huang JW, Yeh HL, Hsu CP, et al.To evaluate the treatment response of locally advanced esophageal cancer after preoperative chemoradiotherapy by FDG-PET/CT scan[J].J Chin Med Assoc, 2015, 78(4): 229-234.DOI: 10.1016/j.jcma.2014.11.003.

相似文献/References:

[1]何燕,苏晋,郑晓霞,等.P-糖蛋白抑制剂在PET显像中的应用研究[J].国际放射医学核医学杂志,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
 He Yan,Su Jin,ZhengXiaoxia,et al.Developing P-glycoprotein inhibitor marked by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
[2]许飞,刘建军,黄钢,等.PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J].国际放射医学核医学杂志,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
 Xu Fei,Liu Jianjun,Huang Gang,et al.The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
[3]胡伟,赵军.小胶质细胞在AD炎性机制中的作用及其常见PET显像剂的应用进展[J].国际放射医学核医学杂志,2016,40(1):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
 Hu Wei,Zhao Jun.Microglia’s Alzheimer disease inflammatory mechanisms and progress of its common application in PET imaging agents[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
[4]张莹莹,王振光,孔艳.PET/CT显像在肺间质纤维化中的应用进展[J].国际放射医学核医学杂志,2016,40(1):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
 Zhang Yingying,Wang Zhenguang,Kong Yan.Application advancement on PET/CT in pulmonary interstitial fibrosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
[5]李海峰,张晓军,李云钢,等.国产模块LOOP环改良法合成11C-蛋氨酸[J].国际放射医学核医学杂志,2016,40(2):106.[doi:10.3760/cma.j.issn.1673-4114.2016.02.004]
 Li Haifeng,Zhang Xiaojun,Li Yungang,et al.Synthesis of 11C-methionine on home-made module by the improved LOOP method[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):106.[doi:10.3760/cma.j.issn.1673-4114.2016.02.004]
[6]史文杰,孟召伟,谭建.基于Deauville标准探讨18F-FDG PET/CT在霍奇金淋巴瘤复发诊断中的应用价值[J].国际放射医学核医学杂志,2016,40(2):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
 Shi Wenjie,Meng Zhaowei,Tan Jian.Value of 18F-FDG PET/CT on diagnosis of Hodgkin lymphoma recurrence using Deauville criterion[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
[7]李海峰,张晓军,张锦明.多巴胺转运蛋白显像剂11C-β-CFT在帕金森病中的应用研究[J].国际放射医学核医学杂志,2016,40(3):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
 Li Haifeng,Zhang Xiaojun,Zhang Jinming.Review of the use of dopamine transporter imaging agent 11C-β-CFT for diagnosing Parkinson disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
[8]尤阳,轩昂,张杰,等.淋巴瘤患者大脑静息葡萄糖代谢改变[J].国际放射医学核医学杂志,2016,40(4):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
 You Yang,Xuan Ang,Zhang Jie,et al.Changes in resting-state brain glucose metabolism in patients with lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
[9]王朋,崔邦平,代文莉,等.18F-FDG PET/CT在前列腺癌中的应用进展[J].国际放射医学核医学杂志,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
 Wang Peng,Cui Bangping,Dai Wenli,et al.Progress in the application of 18F-FDG PET/CT in prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
[10]张巍,杨珂.18f正电子放射性药物生产及使用中医务人员的受照剂量研究[J].国际放射医学核医学杂志,2015,39(5):420.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 016]
 zhang wei,yang ke..the research of radiation dose of 18f-fdg to pet/ct related personnel[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):420.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 016]
[11]李生栩,唐明灯,林端瑜,等.18F-FDG PET/CT在胸段食管鳞癌淋巴结转移中的诊断价值[J].国际放射医学核医学杂志,2016,40(6):408.[doi:10.3760/cma.j.issn.1673-4114.2016.06.002]
 Li Shengxu,Tang Mingdeng,Lin Duanyu,et al.Value of 18F-FDG PET/CT in detecting metastatic lymph nodes of thoracic esophageal squamous cell carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):408.[doi:10.3760/cma.j.issn.1673-4114.2016.06.002]
[12]谢彦婷,郑容.18F-FDG PET/CT在食管癌放疗中的应用[J].国际放射医学核医学杂志,2013,37(1):42.[doi:10.3760/cma.j.issn.1673-4114.2013.01.012]
 XIE Yan-ting,ZHENG Rong.The application of 18F-FDG PET/CT in the radiotherapy of esophageal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(4):42.[doi:10.3760/cma.j.issn.1673-4114.2013.01.012]

备注/Memo

备注/Memo:
收稿日期:2016-2-15;改回日期:。
通讯作者:黄俊星,Email:hjxtz@sina.cn
更新日期/Last Update: 1900-01-01