[1]曹毅,王仲文,沈波.辐射诱导的基因组不稳定性[J].国际放射医学核医学杂志,2003,27(2):84-86.
　CAO Yi,WANG Zhong-wen,SHEN Bo.Radiation-induced genomic instability[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(2):84-86.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第2期
页码:
84-86
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Radiation-induced genomic instability
作者:
曹毅;  王仲文;  沈波
030006 太原, 中国辐射防护研究院
Author(s):
CAO Yi;  WANG Zhong-wen;  SHEN Bo
China Institute for Radiation Protection, Taiyuan 030006, China
关键词:
辐射; 基因组不稳定性; 旁观者效应
Keywords:
radiation; genomic instability; bystander effect
分类号:
Q345+.2
摘要:
辐射诱导的基因组不稳定性的特点是受照细胞后代发生遗传变化的频率增加。基因组不稳定性的生物终点包括核型异常、基因突变和基因扩增及延迟的细胞增殖性死亡等。保持遗传信息稳定的一些关键基因的损伤对基因组不稳定性的发生和传递起重要作用,遗传外因子也会影响基因组不稳定性的发生。辐射诱导的基因组不稳定性对辐射致癌具有重要意义。
Abstract:
Genomic instability induced by radiation is characterized by the increased rate of acquisition of genetic alterations in the progenies of irradiated cell. These changes encompass a diverse set of biological end points, such as kary-otypic abnormolities, gene mutation and amplification, and delayed reproductive cell death etc. Damages of some key genes play important roles in the initiation and transition of genomic instability. Epigenetic factors may influence the onset of genomic instability. Loss of stability of the genome is one of the important aspects of radiation carcinogenesis.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2002-08-14。
作者简介:曹毅(1967-),男,副研究员,,主要从事放射生物学研究。;王仲文(1962-),男,研究员,硕士研究生导师,主要从事放射生物学研究。;沈波(1974-),女,硕士研究生,主要从事放射生物学研究。
更新日期/Last Update: 1900-01-01