[1]沈波.基因组不稳定性与错配修复机制[J].国际放射医学核医学杂志,2003,27(2):87-89.
　SHEN Bo.Genomic instability and mismatch repair mechanism[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(2):87-89.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第2期
页码:
87-89
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Genomic instability and mismatch repair mechanism
作者:
沈波
030006 太原, 中国辐射防护研究院生命科学研究所
Author(s):
SHEN Bo
China Institute for Radiation Protection, Taiyuan 030006, China
关键词:
基因组不稳定性; 错配修复; 细胞周期阻滞
Keywords:
genomic instability; mismatch repair; cell-cycle arrest
分类号:
Q345+.2
摘要:
辐射可以诱导细胞基因组发生不稳定性改变,表现为一系列的延迟突变表型。错配修复机制作为一种重要的复制后修复机制,在维持基因组稳定方面发挥着重要的作用。它是一种保守的修复机制,不仅可以通过异二聚体的形式直接参与修复过程,也可以通过cdc2磷酸化途径对细胞周期进行间接调控。因此,探讨基因组不稳定性与错配修复之间的相互关系,可能是我们深入了解电离辐射的损伤与修复机制的重要内容。
Abstract:
Irradiation can induce genomic instability and produce a series of delayed mutations. As a free-error repair mechanism of post-duplication, mismatch repair plays an essential role in the maintenance of genomic stability. Mismatch is proposed a kind of conservative repair mechanism. Not only can it be involved in the repair process directly by heter-dimers, but it can affect the cell-cycle by cdc2 phophatized path to supervise the cell-cycle indirectly. Therefore, discussing the relation of genomic instability and mismatch repair may represent one of aspects of radiational damage and repair mechanisms

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2002-08-11。
作者简介:沈波(1974-),女,硕士研究生,主要从事放射生物学研究。
更新日期/Last Update: 1900-01-01