[1]仲恒高,童建.α粒子辐射与基因组不稳定性[J].国际放射医学核医学杂志,2004,28(6):267-270.
 ZHONG Heng-gao,TONG Jian.Alpha-particles radiation and genomic instability[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(6):267-270.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
28
期数:
2004年第6期
页码:
267-270
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Alpha-particles radiation and genomic instability
作者:
仲恒高 童建
215007 苏州, 苏州大学放射医学与公共卫生学院
Author(s):
ZHONG Heng-gao TONG Jian
Istitute of Radiation Medicine and Public Health, Suzhou University, Suzhou 215007, China
关键词:
α粒子基因组不稳定性旁效应自由基端粒
Keywords:
alpha particlesgenomic instabilitybystander-effectfree radicalstelomere
分类号:
Q345+.2
摘要:
α粒子照射后除了引起机体本身的可见的变化如细胞死亡、增殖、癌变,其引起的遗传损伤效应也日益受到人们的注意。越来越多的研究表明:辐射可引起基因组不稳定性的过程,使受照射细胞的应答反应传递到子代细胞中,并表现出一系列遗传学变化。基因组不稳定性的机制目前还不甚清楚,可能与旁效应、自由基、DNA修复缺陷、端粒功能失调以及基因大片段缺失等有关。
Abstract:
Alpha-particles can lead to cell death, proliferation and cancerization, but genetic damage is more worth concerning. Many studies have shown that alpha-particles also cause a procedure of genomic instability and the damage can transfer to filial generations. The mechanism is not clear, maybe relate to bystander effect, free radicles, DNA repair-deficiency, telomere function disorder and gene partial or total deletion.

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备注/Memo

备注/Memo:
收稿日期:2004-09-10。
更新日期/Last Update: 1900-01-01