[1]刘光伟,龚守良.细胞凋亡的线粒体调控机制与电离辐射[J].国际放射医学核医学杂志,2003,27(2):90-93.
 LIU Guang-wei,GONG Shou-liang.Mitochondrial control mechanism on apoptosis and ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(2):90-93.
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细胞凋亡的线粒体调控机制与电离辐射(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第2期
页码:
90-93
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Mitochondrial control mechanism on apoptosis and ionizing radiation
作者:
刘光伟 龚守良
30021 吉林长春, 吉林大学公共卫生学院卫生部放射生物学重点实验室
Author(s):
LIU Guang-wei GONG Shou-liang
MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China
关键词:
细胞凋亡线粒体调控机制膜通透性细胞色素c电离辐射
Keywords:
apoptosismitochondriacontrol mechanismpermeabilitycytochrome cionizing radiation
分类号:
Q244;Q756
摘要:
线粒体在外界刺激(如电离辐射)诱发细胞凋亡中起中心调控作用。各种死亡信号通过Bcl-2家族蛋白或直接诱导线粒体膜通透性增加、细胞色素c释放和caspases激活,最终引起细胞凋亡。线粒体膜通透性改变的机制,目前还不完全清楚。简要综述细胞凋亡的线粒体调控机制及电离辐射在其机制中的可能作用。
Abstract:
Mitochondria play a major role in apoptosis triggered by many stimuli. The various death signals induce directly and indirectly (through Bcl-2 family proteins) the increase of mitochondrial membrane permeability, the release of cytochrome c and the activation of caspases. The mechanisms that lead to this permeability are not yet completely understood. Here, we review briefly the mechanisms of mitochondrial control during apoptosis and the possible effects of ionizing radiation in their mechanisms.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2003-01-21。
作者简介:刘光伟(1973-),男,博士研究生,主要从事电离辐射生物效应研究。;龚守良(1945-),男,教授,博士生导师,主要从事电离辐射生物效应研究。
更新日期/Last Update: 1900-01-01