[1]郭丽,范洪学.干细胞在放射医学研究中的进展[J].国际放射医学核医学杂志,2003,27(2):80-83.
 GUO Li,FAN Hong-xue.The advancement of stem cells in radiation medicine[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(2):80-83.
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干细胞在放射医学研究中的进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第2期
页码:
80-83
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
The advancement of stem cells in radiation medicine
作者:
郭丽 范洪学
130021 长春, 吉林大学公共卫生学院毒理学教研室
Author(s):
GUO Li FAN Hong-xue
Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China
关键词:
干细胞放射医学造血干细胞
Keywords:
stem cellsradiation medicinehemopoietic stem cells
分类号:
Q345+.21
摘要:
电离辐射作用于机体后,可致机体发生急性放射病。辐射损伤的远后效应之一是白血病,含有干细胞的骨髓细胞移植是目前挽救急性放射病病人生命的惟一有效的治疗方法。近年来随着干细胞研究的突破性进展,其多向分化潜能及干细胞相互转化可能为辐射损伤病人提供新的干细胞来源;同时随着辐射防护剂研究的深入,促进了损伤后干细胞的恢复。
Abstract:
It may result in acute radiation syndrome after body is exposed to ionizing radiation. The one of long-term effects of irradiation injury is leukemia. The bone marrow cells (BMC) transplantation including stem cells is the only effective therapy for acute radiation syndrome patients. Recently, with the advancement of stem cell research that the stem cells have multipotential and can convert each other, it may supply the new stem source for the irradiation injury patients. At the same time with the further research of radioprotective reagents, the hematopoietic stem cells proliferation after irradiation injury is promoted.

参考文献/References:

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[6] Chute JP, Clark W, Saini A, et al. Rescue of hematopoietic stem cells following high-dose radiation injury using ex vivo culture on endothelial monolayers[J]. Mil Med, 2002, 167(2 Suppl):74-77.
[7] Perkins AC. Enrichment of blood from embryonic stem cells in vitro[J]. Reprod Fertil Dev, 1998, 10(7-8):563-572.
[8] Jackson KA, Mi T, Goodell MA. Hematopoietic potential of stem cells isolated from murine skeletal muscle[J]. Proc Natl Acad Sci USA, 1999, 96(25):14482-14486.
[9] Na Nakorn T, Traver D, Weissman IL, et al. Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S[J]. J Clin Invest, 2002,109(12):1579-1585.
[10] Hudak S, Leach MW, Xu Y, et al. Radioprotective effects of flk2/flt3 ligand[J]. Exp Hematol, 1998,26(6):515-522.
[11] Neta R, Perlstein R, Vogel SN, et al. Role of interleukin 6(IL-6) in protection from lethal irradiation and in endocrine responses to IL-I and tumor necrosis factor[J]. J Exp Med, 1992, 175(3):689-694.
[12] Booth D, Haley JD, Bruskin AM, et al. Transforming growth factor-β3 protects murine small intestinal crypt stem cells and animal survival after irradiation, possibly by reducing stem-cell cycling[J]. Int J Cancer, 2000, 86(1):53-59.
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备注/Memo

备注/Memo:
收稿日期:2002-10-17。
基金项目:吉林省卫生厅医学科研基金项目(200131)
作者简介:郭丽(1973-),女,助教,博士研究生,主要从事间充质干细胞方面的研究。范洪学(1940-),男,教授,博士生导师,主要从事辐射与造血研究。
更新日期/Last Update: 1900-01-01