[1]郝福荣,金一尊.细胞色素P-450与电离辐射的关系[J].国际放射医学核医学杂志,2003,27(2):77-79,83.
 HAO Fu-rong,JIN Yi-zun.Relation between cytochrome P-450 and ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(2):77-79,83.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第2期
页码:
77-79,83
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Relation between cytochrome P-450 and ionizing radiation
作者:
郝福荣1 金一尊2
1. 265200 山东省莱阳市, 中国人民解放军第145医院;
2. 200032 上海, 复旦大学放射医学研究所
Author(s):
HAO Fu-rong1 JIN Yi-zun2
Institute of Radiation Medicine, Fudan University, Shanghai 200032, China
关键词:
细胞色素P-450辐射生物还原活性物
Keywords:
cytochrome P-450radiationbioreductive drugs
分类号:
Q506;Q559.+9
摘要:
电离辐射可以改变细胞色素P-450(主要有CYP1B1、CYP1A1、CYP4A11、CYP2E1等)的活性和(或)mRNA、蛋白含量,从而影响药物代谢和有毒化学物的生物转化过程及其生物学作用。细胞色素P-450参与了生物还原活性物TMQ、AQ4N在机体内的还原。动物实验和已有的临床研究表明,调节P-450可以提高生物还原活性物的辐射增敏作用和抗肿瘤作用。
Abstract:
Ionizing radiation can change the activity and/or the expression of mRNA, protein of Cytochrome P-450 CYP1B1, 1A1, 4A11, 2E1), consequently influence the biotransformation and biological effects of the drugs and toxi-coid metabolization. Cytochrome P-450 participated in the reduction of bioreductive drugs (including TMQ-AQ4N). Animal experiments and clinical trials show Cytochrome P-450 can be taken advantage to exert well sensitization for radiotherapy and chemotherapy.

参考文献/References:

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[6] Goeptar AR, te Koppele JM, van Maanen JM, et al.One-electron reductive bioactivation of 2,3,5,6-tetramethylben-zoquinone by cytochrome P450[J].Biochem Pharmacol, 1992,43(2):343-352.
[7] Patterson LH.Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents:a new class of bioreductive agent[J].Cancer Metastasis Rev,1993,12(2):119-134.
[8] Raleigh SM, Wanogho E, Burke MD, et al.Rat cytochromes P450(CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer prodrug[J].Xenobiotica,1999,29(11):1115-1122.
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备注/Memo

备注/Memo:
收稿日期:2002-08-30。
基金项目:国家自然科学基金资助项目(编号:30100042)
作者简介:郝福荣(1974-),男,医师,博士研究生,主要从事细胞色素P-450与药物代谢的研究。;金一尊(1939-),女,研究员,博士生导师,主要从事肿瘤增敏药物研究。
更新日期/Last Update: 1900-01-01