[1]李杨.放射性肺纤维化分子机制的研究进展[J].国际放射医学核医学杂志,2003,27(2):75-77.
　LI Yang.Studies on the molecular pathogenesis of radiation pulmonary fibrosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(2):75-77.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第2期
页码:
75-77
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Studies on the molecular pathogenesis of radiation pulmonary fibrosis
作者:
李杨
100850 北京, 军事医学科学院放射医学研究所实验病理研究室
Author(s):
LI Yang
Institute of Radiation Medicine, Academy Military Medical Science, Beijing 100850, China
关键词:
放射性肺纤维化; 细胞因子; 粘附分子; 血管活性多肽
Keywords:
radiation pulmonary fibrosis; cytokine; adhesion molecules; vasoactive polypeptide
分类号:
R818.02
摘要:
放射性肺纤维化是临床放射治疗的常见并发症,也可见于战时核辐射、平时核事故。关于其发病机制的研究已深入到分子水平,多种细胞因子、粘附分子、血管活性多肽参与了放射性肺纤维化的发生发展,某些基因与其发生具有相关性。分子机制的研究也给防治措施提供了新思路和新途径。
Abstract:
Radiation pulmonary fibrosis(RPF) is a frequent side effect of thoracic radiotherapy for breast neoplasm and total body irradiation before bone marrow transplantation. Studies on its pathogenesis have arrived at molecular level. Many cytokines, adhesion molecules and vasoactive substances all play important role in the course of RPF. Moreover, there exists genetic loci that has relation with RPF. Furthermore, studies on the molecular pathogenesis of RPF have pro? vided new ideas and new measures for the precaution and therapy of RPF.

参考文献/References:

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[3] Michele M, Jean-louse L, Sylvie D, et al. TGF-β1 and radiation fibrosis:a master switch and a specific therapeutic target?[J]. Int J Radiat Oncol Biol Phys, 2000, 47(2):277-290.
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[9] Michael B, Datto W, Yong Y, et al. Functional analysis of the transforming growth factor responsive elements in the WAF1/Cip1/P21 promoter[J]. J Biol Chem, 1995, 270(48):28623-28628.
[10] Johnston CJ, Williams JP, Okunieff P. Radiation-induced pulmonary fibrosis:examination of chemokine and chemokine receptor families[J]. Radiat Res, 2002, 157(3):256-265.
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[12] Song LW, Wang DW, Cui XM, et al. Kinetic alterations of angiotensin-Ⅱ and nitric oxide in radiation pulmonary fibro-sis[J]. J Environ Pathol Toxicol Oncol, 1998,17(2):141-150.
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备注/Memo

备注/Memo:
收稿日期:2002-08-16。
基金项目:国家自然科学基金项目(30170292)
作者简介:李杨(1973-),女,博士研究生,主要从事放射病理学研究。
更新日期/Last Update: 1900-01-01