[1]曹京旭,张旭志.细胞因子与放射性肺损伤[J].国际放射医学核医学杂志,2001,25(4):181-185.
 CAO Jing-xu,ZHANG Xu-zhi.Cytokines and radiation-induced pulmonary injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(4):181-185.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第4期
页码:
181-185
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Cytokines and radiation-induced pulmonary injury
作者:
曹京旭 张旭志
116021 辽宁 大连, 沈阳军区210医院放射科放疗室
Author(s):
CAO Jing-xu ZHANG Xu-zhi
Department of Radiotherapy, PLA 210 Hospital, Liaoning Dalian 116021, China
关键词:
细胞因子放射性肺损伤放射性肺炎放射性肺纤维化
Keywords:
cytokinesradiation induced pulmonary injuryradiation pneumonitispulmonary fibrosis
分类号:
R818.74
摘要:
细胞因子作为分子水平的生物效应调节因子,在放射性肺损伤的发病及病理过程中的作用已引起广泛的重视。在研究细胞因子致病作用的同时,亦进一步探讨相关细胞因子在放射性肺损伤的预测、监控、预防和治疗方面的意义。
Abstract:
As a biologic modulator of molecular biology,the cytokines in the lung play a important role in radiation induced injury of the normal lung and it would contribute to the predicting,preventing and treating of radiation induced pulmonary injury.

参考文献/References:

[1] Rubin P, Johnston CJ, Williams JP, et al.A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis[J].Int J Radioat Oncol Biol Phys, 1995, 33(1):99-109.
[2] Rubin P, Finkelstein J, Shapiro D, et al.Moecular biology mechanisms in the radiation induction of pulmonary injury syndromes:Interrelationship between the alveolar macrophage and the septal fibroblast[J].Int J Radiat Oncol Biol Phys, 1992, 24(1):93-101.
[3] Anscher M S, M urase T, Prescott DM, et al.Changes in plasma TGF-β levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis[J].Int J Radiat Oncol Biol Phys, 1994, 30(3):671-676.
[4] Roberts CM, Foulcher E, Zaunders JJ, et al.Radiation pneumonitis:a possible lymphocyte-mediated hyper-sensitivity reaction[J].Ann Int Med, 1993, 118:696-700.
[5] Neta R.Modulation with cytokine of radiation injury:suggested mechanisms of acion[J].Environ Health Perspact.1997, 105:1463-1465.
[6] Westermann W, Schobl R, Rieber EP, et al.Th2 cell as effectors in postirradiation pulmonary damage preceding fibrosis in the rat[J].Int J Radiat Biol.1999, 75:629-638.
[7] Franko AJ, Sharplin J, Ghahary A, et al.Immunohis-tochermical localization of transforming growth factor-β and tumor nacrosis factorαin the lung fibrosis prone and ‘non-fibrosing’ mice during the latent period and early phase after irrradiation[J].Radiati Res, 1997, 147:245-256.
[8] Anscher M S, Kong FM, Jirtle RL, et al.The relevance of transforming growth factor beta 1 in pulmonary in jury after radiation therapy[J].Lung Cancer, 1998, 19(2):109-120.
[9] Rosiello RA, Merrill WW, Rockwell S, et al.Radiation pneumonitis-brochoalveolar lavage assessment and moculation by a recombinant bytokine[J].Am Rev Respir Dis, 1993, 148:1671-1676.
[10] Danilenko DM.Preclinical and early clinical development of keratinocyte growth factor, and epithelial-specific tissue growth factor[J].Toxicol Pathol, 1992, 27(1):64-71.
[11] Savla U, Waters CM.Barrier function of airway epithelium:Effects of radiation and protection by ker-atinocyte growth factor[J].Radiat Res, 1998, 150(2):195-203.

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备注/Memo

备注/Memo:
收稿日期:2001/4/28。
作者简介:曹京旭(1959-),女,北京人,沈阳军区210医院放射科放疗室副主任医师;张旭志(1963-),吉林人,沈阳军区210医院放射科放疗室主治医师;张旭志(1963-),吉林人,沈阳军区210医院放射科放疗室主治医师。
更新日期/Last Update: 1900-01-01