[1]郭万峰,丁桂荣,韩良辅.应用生物标志对肿瘤辐射敏感性的研究[J].国际放射医学核医学杂志,2001,25(4):185-188.
 GUO Wan-feng,DING Gui-rong,HAN Liang-fu.Application of biomarker to study on tumor radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(4):185-188.
点击复制

应用生物标志对肿瘤辐射敏感性的研究(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第4期
页码:
185-188
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Application of biomarker to study on tumor radiosensitivity
作者:
郭万峰1 丁桂荣1 韩良辅2
1. 710032 西安, 第四军医大学放射医学教研室;
2. 710032 西安, 第四军医大学西京医院放疗科
Author(s):
GUO Wan-feng1 DING Gui-rong1 HAN Liang-fu2
1. Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, China;
2. Department of Radiotherapy, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, China
关键词:
辐射敏感性生物标志放射治疗
Keywords:
radiosensitivitybiomarkerradiotherapy
分类号:
Q691;R730.5
摘要:
为了实现肿瘤放射治疗方案的个体化,确定肿瘤的辐射敏感性是一个重要内容。许多实验室从不同水平研究了应用单个生物标志和多个生物标志在预测肿瘤辐射敏感性时的作用。虽然目前尚无特异性的生物标志,但提供了良好的研究模式。
Abstract:
To definite tumor radiosensitivity is important for applying the schedules of individualization of patient radiotherapy. Many laboratories were carrying on the research which predict the tumor radiosesitivity with one biomarker or/and multi-biomarker in various levels .At present has not witnessed the specific biomarker, but it provides an excellent model for predicting tumor radiosensitivity.

参考文献/References:

[1] Bjork-Eriksson T, West C, Karlsson E, et al.Tumor radiosensitivity (SF2) is a prognostic factor for local control in head and neck cancers[J].Int J Radiat Oncol Biol Phys, 2000, 46(1):13-19.
[2] Widel M, Jedrus S, Owczarek S, et al.The increment of micronucleus frequency in cervical carcinoma during irradiation in vivo and its prognostic value for tumour radiocurability[J].Br J Cancer, 1999, 80(10):1599-1607.
[3] Lee T, O’Brien KF, Naves JL, et al.Micronuclei in lymphocytes of prostate cancer patients undergoing radiation therapy[J].Mutat Res, 2000, 469(1):63-70.
[4] Abend M, Rhein A, Gilbertz KP, et al.Correlation of micronucleus and apoptosis assay with reproductive cell death[J].Int J Radiat Biol, 1995, 67:315-326.
[5] Verheij M, Bartelink H.Radiation-induced apoptosis[J].Cell Tissue Res, 2000, 301(1):133-142.
[6] Levine EL, Davidson SE, Robert SA, et al.Apoptosis as predictor of response to radiotherapy in cervical carcinoma[J].Lancet, 1994, 344:472.
[7] Zhivotovsky B, Joseph B, Orrenius S.Tumor radiosensitivity and apoptosis[J].Exp Cell Res, 1999, 248(1):10-17.
[8] Olive PL, Durand RE.Apoptosis:an indicator of radiosensitivity in vitro?[J].Int J Radiat Biol, 1997, 71:695-707.
[9] Schwartz JL, Murnane J, Weichselbaum RR.The contribution of DNA ploidy to radiation sensitivity inhuman tumour cell lines[J].Br J Cancer, 1999, 79(5-6):744-747.
[10] Coco Martin JM, Mooren E, Ottenheim C, et al.Potential of radiation-induced chromosome aberraions to predict radiosensitivity in human tumour cells[J].Int J Radiat Biol, 1999, 75(9):1161-1168.
[11] Dikomy E, Dahm-Daphi J, Martensen R, et al.1998, Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mam-malian cell lines[J].Int J Radiat Biol, 1998, 73(3):269-278.
[12] Bistow RG, Benchimol S, Hill RP.The p53 gene as a modifier of intrinsic radiosensitivity:implications for radiotherapy[J].Radiother Oncol, 1996, 40(3):197-223.
[13] Bae I, Smith ML, Sheikh MS, et al.An abnormality in the p53 pathway following γ-irradition in many wild-type p53 human melanoma lines[J].Cancer Res, 1996, 56(4):840-847.
[14] Dahm-Daphi J.p53:biology and role for cellular radiosensitivity[J].Strahlenther Onkol, 2000, 176(6):278-285.
[15] Kariya S, Ogawa Y, Yoshida S, et al.X-irradiation enhances the expression of Bcl-2 in HL-60 cells:The resulting effects on apoptosis and radiosensitivity[J].Int J Mol Med, 1999, 3(2):145-152.
[16] Guo GZ, Sasai K, Oya N, et al.Simultaneous evaluation of radiation-induced apoptosis and micronuclei in five cell lines[J].Int J Radiat Biol, 1998, 73(3):297-302.
[17] Guo GZ, Sasai K, Oya N, et al.A significant correlation between clonogenic radiosensitivity and the simul-taneous assessment of micronucleus and apoptotic cell frequencies[J].Int J Radiat Biol, 1999, 75(7):857-864.
[18] Abend M, Kehe K, Riedel M, et al.Correlation of micronucleus and apoptosis assays with reproductive cell death can be improved by considering other modes of death[J].Int J Radiat Biol, 2000, 76(2):249-259.
[19] Peltenburg LT.Radiosensitivity of tumor cells.Onco-genes and apoptosis[J].Q J Nucl Med, 2000, 44(4):355-364.
[20] Achary MP, Jaggernauth W, Gross E, et al.Cell lines from the same cervical carcinoma but with different radiosensitivities exhibit different cDN A microarray patterns of gene expression[J].Cytogenet Cell Genet, 2000, 91(1-4):39-43.
[21] Bjork-Eriksson T, West CM, Cvetskovska E, et al.The lack of correlation between proliferation(Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers[J].Br J Cancer, 1999, 80(9):1400-1404.
[22] Levine EL, Renehan A, Gossiel R, et al.Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma[J].Radiother Oncol, 1995, 37(1):1-9.
[23] Rosen EM, Fan S, Goldberg ID, et al.Biological basis of radiation sensitivity.Part 2:Cellular and molecular determinants of radiosensitivity[J].Oncology(Huntingt) 2000, 14(5):741-757; 757-758; 761-766.

相似文献/References:

[1]陈洪雷,彭勇.高压氧与肿瘤放射治疗[J].国际放射医学核医学杂志,2005,29(6):289.
 CHEN Hong-lei,PENG Yong.Hyperbaric oxygenation and radiation therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):289.
[2]杜维霞.辐射敏感性影响因素研究[J].国际放射医学核医学杂志,2003,27(5):238.
 DU Wei-xia.Studies on factors of influence radiation sensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(4):238.
[3]许建华.Egr-1基因的辐射生物学效应研究进展[J].国际放射医学核医学杂志,2002,26(2):76.
 XU Jian-hua.Advances in the research of the role of Egr-1 gene in cells’ response to ionizing radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(4):76.
[4]王丽平,梁克.细胞凋亡与辐射敏感性[J].国际放射医学核医学杂志,2000,24(2):75.
 WANG Li-ping,LIANG Ke.Apoptosis and radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(4):75.
[5]朱光旭,王小华.肿瘤辐射敏感性与细胞凋亡[J].国际放射医学核医学杂志,2000,24(2):78.
 ZHU Guang-xu,Wang Xiao-hua.Tumor radiosensitivity and apoptosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(4):78.
[6]李林,史剑慧.神经酰胺与辐射诱导细胞凋亡[J].国际放射医学核医学杂志,2000,24(2):85.
 LI Lin,SHI Jian-hui.Ceramide and apoptosis induced by radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(4):85.
[7]鞠永健.放射治疗中肿瘤控制概率的计算方法[J].国际放射医学核医学杂志,2000,24(3):138.
 JU Yong-jian.The calculating methods of tumor control probability in radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(4):138.
[8]于文儒,王继先.个体辐射敏感性差异的研究进展及意义[J].国际放射医学核医学杂志,1997,21(2):87.
[9]菅原努.提倡新模式的低剂量放射生物学[J].国际放射医学核医学杂志,1997,21(5):193.
[10]于文儒,等.辐射敏感性与p53基因突变关系的研究进展[J].国际放射医学核医学杂志,1996,20(5):233.

备注/Memo

备注/Memo:
收稿日期:2001/4/13。
作者简介:郭万峰(1974-),男,西安第四军医大学放射医学教研室硕士研究生;丁桂荣(1971-),女,西安第四军医大学放射医学教研室博士;韩良辅(1964-),男,西安第四军医大学西京医院放疗科博士。
更新日期/Last Update: 1900-01-01